Sleep and headache: A bidirectional relationship

Carlo Lovati, Domenico D'Amico, Elisa Raimondi, Claudio Mariani, Pierluigi Bertora

Research output: Contribution to journalArticlepeer-review


Sleep and pain perception are two phylogenetically well-conserved functions, strictly influenced by environmental and psychological factors, and are able to interact reciprocally both in physiological and pathological situations. Sleep and head-pain perception share the involvement of several structures, such as the thalamus, the hypothalamus and brainstem nuclei, including the locus coeruleus and raphe nuclei. There ais clinical evidence indicating that sleep disorders can precede the appearance of certain headaches and that head pain, especially when frequent, can, in turn, affect sleep quality. In the present work the anatomy, physiology and pathology of sleep and head-pain perception will be reviewed with the aim of highlighting the points of contact and possible unifying treatment strategies.

Original languageEnglish
Pages (from-to)105-117
Number of pages13
JournalExpert Review of Neurotherapeutics
Issue number1
Publication statusPublished - Jan 2010


  • Headache
  • Insomnia
  • Migraine
  • Pain
  • Parasomnia
  • Sleep

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Pharmacology (medical)


Dive into the research topics of 'Sleep and headache: A bidirectional relationship'. Together they form a unique fingerprint.

Cite this