Sleep and quality of life in restless legs syndrome

Marco Zucconi, Mauro Manconi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Restless legs syndrome (RLS) is a sensory-motor disorder characterized by uncomfortable and disagreeable sensations at lower limbs, urge to move them and peaking during rest periods and at evening/night, with impact on sleep, causing insomnia and sleep fragmentation. Both severity of the sensory symptoms and periodic legs movements during sleep (PLMS) contribute to sleep impairment and, consequently, to a reduced quality of life (QoL). Measurement of RLS impact on QoL is made, both in clinical and epidemiological studies, by means of a Short Form-36 (SF-36) of health survey questionnaire and by validated and disease-specific QoL scales (RLSQoL and Hopkins RLSQoL). Both types of measures indicated a significant impact of RLS on QoL in different clinical and prevalence studies and showed good reliability, reproducibility and responsiveness. Moreover, QoL significantly improved, both in short-term studies and in recently published long-term protocols, with dopaminergic treatment in comparison to placebo. In what measure RLS per se, some disease-specific symptoms as restlessness and bad sleep or other co-morbidity factors, contribute to the impairment of QoL remain to be further investigated.

Original languageEnglish
Title of host publicationSleep and Quality of Life in Clinical Medicine
PublisherHumana Press
Pages101-106
Number of pages6
ISBN (Print)9781603273404
DOIs
Publication statusPublished - 2008

Keywords

  • insomnia
  • periodic leg movements
  • quality of life
  • Restless legs syndrome
  • sleep
  • therapy

ASJC Scopus subject areas

  • Medicine(all)

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