Sleep and upper airway obstruction in children with achondroplasia

M. Zucconi, G. Weber, V. Castronovo, L. Ferini-Strambi, F. Russo, G. Chiumello, S. Smirne

Research output: Contribution to journalArticlepeer-review


Objective: The features of achondroplasia, the most common form of dwarfism, includes short cranial base and midface hypoplasia; both abnormalities increased the risk of upper airway obstruction during sleep. The aim of our study was to evaluate sleep and respiratory function of children with achondroplasia and to differentiate central from obstructive apnea. We also wanted to correlate apneic events with foramen magnum stenosis. Study design: Sixteen children with achondroplasia (mean age, 4.7 years) were studied by nocturnal polysomnography and brain computed tomography or magnetic resonance imaging. A comparison of sleep and respiratory findings was made between the study group and 25 children with adenotonsillar hypertrophy. Results: The study revealed no significant difference between groups with respect to sleep architecture. We also found no relationship between apnea type and foramen magnum stenosis. Twelve children (75%) with achondroplasia had significant upper airway obstruction during sleep, with symptoms of continuous snoring and periods of brief obstructive apnea, hypopnea, or both. The mean apneahypopnea index (per hour of sleep) did not differ significantly between the two groups. However, the breathing rate during sleep was increased in children with achondroplasia. These findings indicate that the most important breathing disorder during sleep in children with achondroplasia is upper airway obstruction. Conclusion: We conclude that polysomnography with detailed scoring of breathing abnormalities is a useful tool in evaluating sleep-disordered breathing in children with achondroplasia.

Original languageEnglish
Pages (from-to)743-749
Number of pages7
JournalJournal of Pediatrics
Issue number5
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


Dive into the research topics of 'Sleep and upper airway obstruction in children with achondroplasia'. Together they form a unique fingerprint.

Cite this