Sleep and waking modulate spine turnover in the adolescent mouse cortex

Stephanie Maret, Ugo Faraguna, Aaron B. Nelson, Chiara Cirelli, Giulio Tononi

Research output: Contribution to journalArticlepeer-review


Cortical development involves synaptic formation and elimination. Although synaptogenesis predominates in the early stages and pruning in the later stages, the two processes are thought to happen concurrently. In adults, synaptic strength is modulated by behavioral state, and we asked whether synaptic remodeling may be affected by sleep and waking states. Using two-photon microscopy in adolescent mice, we found that waking results in a net increase in cortical spines, whereas sleep is associated with net spine loss.

Original languageEnglish
Pages (from-to)1418-1420
Number of pages3
JournalNature Neuroscience
Issue number11
Publication statusPublished - Nov 2011

ASJC Scopus subject areas

  • Neuroscience(all)


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