Apnee notturne e scompenso cardiaco: Fisiopatologia, diagnosi e terapia

Translated title of the contribution: Sleep apnea and heart failure: Pathophysiology, diagnosis and therapy

Cinzia Monda, Oriana Scala, Stefania Paolillo, Gianluigi Savarese, Milena Cecere, Carmen D'Amore, Antonio Parente, Francesca Musella, Susanna Mosca, Pasquale Perrone Filardi

Research output: Contribution to journalArticlepeer-review


Sleep apnea, defined as a pathologic pause in breathing during sleep >10 s, promotes the progression of chronic heart failure and may be a predictor of poor prognosis. It causes, in fact, several mechanical, hemodynamic, chemical and inflammatory changes that negatively compromise cardiovascular homeostasis of heart failure patients. Sleep apnea is recognized as sleep apnea syndrome when specific symptoms, such as sleepiness and headache during the daytime and snoring, are present and is diagnosed with an overnight test called polysomnography. There are two different forms of sleep apnea, central and obstructive. Breathing is interrupted by the loss of respiratory drive and the lack of respiratory effort in the central form, which affects about 40-60% of heart failure patients. In obstructive sleep apnea, breathing stops when throat muscles relax, despite respiratory effort. This form affects about 3% of the general population, while it is present in at least 30% of heart failure patients. The diagnosis of sleep disorders in heart failure becomes very important to help patients adopting lifestyle changes and starting specific therapies to improve quality of life and retard the progression of chronic heart failure.

Translated title of the contributionSleep apnea and heart failure: Pathophysiology, diagnosis and therapy
Original languageItalian
Pages (from-to)815-822
Number of pages8
JournalGiornale Italiano di Cardiologia
Issue number11
Publication statusPublished - Nov 2010

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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