OBJECTIVE: Benzodiazepines (BZDs) are the most commonly prescribed compounds in insomnia. A long-term of BZDs use may cause dependence and abuse. The aim of this study was to evaluate sleep architecture and microstructure (in terms of cyclic alternating pattern - CAP - analysis and of sleep EEG power spectral analysis) in a group of long-term users of high doses of BZDs for their primary chronic insomnia. METHODS: Twenty patients consecutively admitted at the Sleep Centre for drug discontinuation and 13 matched healthy controls underwent a full nocturnal video-polysomnographic recording, after one adaptation night. RESULTS: Significant differences were found in time in bed, REM sleep latency and sleep stage 1% which were increased in patients compared to controls, while CAP rate was dramatically decreased. During NREM sleep, patients showed a clear decrease in the relative power of delta band. CONCLUSIONS: Our data demonstrate that in adults with chronic insomnia, long-term use of high doses of BZDs induces a severe disruption of sleep microstructure, while sleep architecture seems to be much less affected. SIGNIFICANCE: The long term use of high doses of BZDs for chronic insomnia induces a marked depression of slow wave activity and of its physiological instability. Copyright © 2017 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
|Number of pages||7|
|Journal||Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology|
|Publication status||Published - 2017|
Manconi, M., Ferri, R., Miano, S., Maestri, M., Bottasini, V., Zucconi, M., & Ferini-Strambi, L. (2017). Sleep architecture in insomniacs with severe benzodiazepine abuse. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 128(6), 875-881. https://doi.org/10.1016/j.clinph.2017.03.009