Sleep deprivation and Modafinil affect cortical sources of resting state electroencephalographic rhythms in healthy young adults

Claudio Del Percio, Philippe Derambure, Giuseppe Noce, Roberta Lizio, David Bartrés Faz, Olivier Blin, Pierre Payoux, Dominique Deplanque, Déborah Méligne, Nicolas Chauveau, Jean Louis Bourriez, Catherine Casse-Perrot, L. Lanteaume, Claire Thalamas, Juergen Dukart, Raffaele Ferri, Maria Teresa Pascarelli, Jill C. Richardson, R. Bordet, Claudio Babiloni

Research output: Contribution to journalArticlepeer-review


Objective: It has been reported that sleep deprivation affects the neurophysiological mechanisms underpinning the vigilance. Here, we tested the following hypotheses in the PharmaCog project ( (i) sleep deprivation may alter posterior cortical delta and alpha sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms in healthy young adults; (ii) after the sleep deprivation, a vigilance enhancer may recover those rsEEG source markers. Methods: rsEEG data were recorded in 36 healthy young adults before (Pre-sleep deprivation) and after (Post-sleep deprivation) one night of sleep deprivation. In the Post-sleep deprivation, these data were collected after a single dose of PLACEBO or MODAFINIL. rsEEG cortical sources were estimated by eLORETA freeware. Results: In the PLACEBO condition, the sleep deprivation induced an increase and a decrease in posterior delta (2–4 Hz) and alpha (8–13 Hz) source activities, respectively. In the MODAFINIL condition, the vigilance enhancer partially recovered those source activities. Conclusions: The present results suggest that posterior delta and alpha source activities may be both related to the regulation of human brain arousal and vigilance in quiet wakefulness. Significance: Future research in healthy young adults may use this methodology to preselect new symptomatic drug candidates designed to normalize brain arousal and vigilance in seniors with dementia.

Original languageEnglish
Pages (from-to)1488-1498
Number of pages11
JournalClinical Neurophysiology
Issue number9
Publication statusPublished - Sep 1 2019


  • Alzheimer's disease (AD)
  • Exact low-resolution brain electromagnetic source tomography (eLORETA)
  • Modafinil
  • Resting state electroencephalographic (rsEEG) rhythms
  • Sleep deprivation

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)


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