Sleep deprivation and Modafinil affect cortical sources of resting state electroencephalographic rhythms in healthy young adults

Claudio Del Percio, Philippe Derambure, Giuseppe Noce, Roberta Lizio, David Bartrés Faz, Olivier Blin, Pierre Payoux, Dominique Deplanque, Déborah Méligne, Nicolas Chauveau, Jean Louis Bourriez, Catherine Casse-Perrot, L. Lanteaume, Claire Thalamas, Juergen Dukart, Raffaele Ferri, Maria Teresa Pascarelli, Jill C. Richardson, R. Bordet, Claudio Babiloni

Research output: Contribution to journalArticle

Abstract

Objective: It has been reported that sleep deprivation affects the neurophysiological mechanisms underpinning the vigilance. Here, we tested the following hypotheses in the PharmaCog project (www.pharmacog.org): (i) sleep deprivation may alter posterior cortical delta and alpha sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms in healthy young adults; (ii) after the sleep deprivation, a vigilance enhancer may recover those rsEEG source markers. Methods: rsEEG data were recorded in 36 healthy young adults before (Pre-sleep deprivation) and after (Post-sleep deprivation) one night of sleep deprivation. In the Post-sleep deprivation, these data were collected after a single dose of PLACEBO or MODAFINIL. rsEEG cortical sources were estimated by eLORETA freeware. Results: In the PLACEBO condition, the sleep deprivation induced an increase and a decrease in posterior delta (2–4 Hz) and alpha (8–13 Hz) source activities, respectively. In the MODAFINIL condition, the vigilance enhancer partially recovered those source activities. Conclusions: The present results suggest that posterior delta and alpha source activities may be both related to the regulation of human brain arousal and vigilance in quiet wakefulness. Significance: Future research in healthy young adults may use this methodology to preselect new symptomatic drug candidates designed to normalize brain arousal and vigilance in seniors with dementia.

Original languageEnglish
Pages (from-to)1488-1498
Number of pages11
JournalClinical Neurophysiology
Volume130
Issue number9
DOIs
Publication statusPublished - Sep 1 2019

Fingerprint

Sleep Deprivation
Young Adult
Arousal
modafinil
Wakefulness
Brain
Dementia

Keywords

  • Alzheimer's disease (AD)
  • Exact low-resolution brain electromagnetic source tomography (eLORETA)
  • Modafinil
  • Resting state electroencephalographic (rsEEG) rhythms
  • Sleep deprivation

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Sleep deprivation and Modafinil affect cortical sources of resting state electroencephalographic rhythms in healthy young adults. / Del Percio, Claudio; Derambure, Philippe; Noce, Giuseppe; Lizio, Roberta; Faz, David Bartrés; Blin, Olivier; Payoux, Pierre; Deplanque, Dominique; Méligne, Déborah; Chauveau, Nicolas; Bourriez, Jean Louis; Casse-Perrot, Catherine; Lanteaume, L.; Thalamas, Claire; Dukart, Juergen; Ferri, Raffaele; Pascarelli, Maria Teresa; Richardson, Jill C.; Bordet, R.; Babiloni, Claudio.

In: Clinical Neurophysiology, Vol. 130, No. 9, 01.09.2019, p. 1488-1498.

Research output: Contribution to journalArticle

Del Percio, C, Derambure, P, Noce, G, Lizio, R, Faz, DB, Blin, O, Payoux, P, Deplanque, D, Méligne, D, Chauveau, N, Bourriez, JL, Casse-Perrot, C, Lanteaume, L, Thalamas, C, Dukart, J, Ferri, R, Pascarelli, MT, Richardson, JC, Bordet, R & Babiloni, C 2019, 'Sleep deprivation and Modafinil affect cortical sources of resting state electroencephalographic rhythms in healthy young adults', Clinical Neurophysiology, vol. 130, no. 9, pp. 1488-1498. https://doi.org/10.1016/j.clinph.2019.06.007
Del Percio, Claudio ; Derambure, Philippe ; Noce, Giuseppe ; Lizio, Roberta ; Faz, David Bartrés ; Blin, Olivier ; Payoux, Pierre ; Deplanque, Dominique ; Méligne, Déborah ; Chauveau, Nicolas ; Bourriez, Jean Louis ; Casse-Perrot, Catherine ; Lanteaume, L. ; Thalamas, Claire ; Dukart, Juergen ; Ferri, Raffaele ; Pascarelli, Maria Teresa ; Richardson, Jill C. ; Bordet, R. ; Babiloni, Claudio. / Sleep deprivation and Modafinil affect cortical sources of resting state electroencephalographic rhythms in healthy young adults. In: Clinical Neurophysiology. 2019 ; Vol. 130, No. 9. pp. 1488-1498.
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T1 - Sleep deprivation and Modafinil affect cortical sources of resting state electroencephalographic rhythms in healthy young adults

AU - Del Percio, Claudio

AU - Derambure, Philippe

AU - Noce, Giuseppe

AU - Lizio, Roberta

AU - Faz, David Bartrés

AU - Blin, Olivier

AU - Payoux, Pierre

AU - Deplanque, Dominique

AU - Méligne, Déborah

AU - Chauveau, Nicolas

AU - Bourriez, Jean Louis

AU - Casse-Perrot, Catherine

AU - Lanteaume, L.

AU - Thalamas, Claire

AU - Dukart, Juergen

AU - Ferri, Raffaele

AU - Pascarelli, Maria Teresa

AU - Richardson, Jill C.

AU - Bordet, R.

AU - Babiloni, Claudio

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Objective: It has been reported that sleep deprivation affects the neurophysiological mechanisms underpinning the vigilance. Here, we tested the following hypotheses in the PharmaCog project (www.pharmacog.org): (i) sleep deprivation may alter posterior cortical delta and alpha sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms in healthy young adults; (ii) after the sleep deprivation, a vigilance enhancer may recover those rsEEG source markers. Methods: rsEEG data were recorded in 36 healthy young adults before (Pre-sleep deprivation) and after (Post-sleep deprivation) one night of sleep deprivation. In the Post-sleep deprivation, these data were collected after a single dose of PLACEBO or MODAFINIL. rsEEG cortical sources were estimated by eLORETA freeware. Results: In the PLACEBO condition, the sleep deprivation induced an increase and a decrease in posterior delta (2–4 Hz) and alpha (8–13 Hz) source activities, respectively. In the MODAFINIL condition, the vigilance enhancer partially recovered those source activities. Conclusions: The present results suggest that posterior delta and alpha source activities may be both related to the regulation of human brain arousal and vigilance in quiet wakefulness. Significance: Future research in healthy young adults may use this methodology to preselect new symptomatic drug candidates designed to normalize brain arousal and vigilance in seniors with dementia.

AB - Objective: It has been reported that sleep deprivation affects the neurophysiological mechanisms underpinning the vigilance. Here, we tested the following hypotheses in the PharmaCog project (www.pharmacog.org): (i) sleep deprivation may alter posterior cortical delta and alpha sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms in healthy young adults; (ii) after the sleep deprivation, a vigilance enhancer may recover those rsEEG source markers. Methods: rsEEG data were recorded in 36 healthy young adults before (Pre-sleep deprivation) and after (Post-sleep deprivation) one night of sleep deprivation. In the Post-sleep deprivation, these data were collected after a single dose of PLACEBO or MODAFINIL. rsEEG cortical sources were estimated by eLORETA freeware. Results: In the PLACEBO condition, the sleep deprivation induced an increase and a decrease in posterior delta (2–4 Hz) and alpha (8–13 Hz) source activities, respectively. In the MODAFINIL condition, the vigilance enhancer partially recovered those source activities. Conclusions: The present results suggest that posterior delta and alpha source activities may be both related to the regulation of human brain arousal and vigilance in quiet wakefulness. Significance: Future research in healthy young adults may use this methodology to preselect new symptomatic drug candidates designed to normalize brain arousal and vigilance in seniors with dementia.

KW - Alzheimer's disease (AD)

KW - Exact low-resolution brain electromagnetic source tomography (eLORETA)

KW - Modafinil

KW - Resting state electroencephalographic (rsEEG) rhythms

KW - Sleep deprivation

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