Abstract
Objective: It has been reported that sleep deprivation affects the neurophysiological mechanisms underpinning the vigilance. Here, we tested the following hypotheses in the PharmaCog project (www.pharmacog.org): (i) sleep deprivation may alter posterior cortical delta and alpha sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms in healthy young adults; (ii) after the sleep deprivation, a vigilance enhancer may recover those rsEEG source markers. Methods: rsEEG data were recorded in 36 healthy young adults before (Pre-sleep deprivation) and after (Post-sleep deprivation) one night of sleep deprivation. In the Post-sleep deprivation, these data were collected after a single dose of PLACEBO or MODAFINIL. rsEEG cortical sources were estimated by eLORETA freeware. Results: In the PLACEBO condition, the sleep deprivation induced an increase and a decrease in posterior delta (2–4 Hz) and alpha (8–13 Hz) source activities, respectively. In the MODAFINIL condition, the vigilance enhancer partially recovered those source activities. Conclusions: The present results suggest that posterior delta and alpha source activities may be both related to the regulation of human brain arousal and vigilance in quiet wakefulness. Significance: Future research in healthy young adults may use this methodology to preselect new symptomatic drug candidates designed to normalize brain arousal and vigilance in seniors with dementia.
| Original language | English |
|---|---|
| Pages (from-to) | 1488-1498 |
| Number of pages | 11 |
| Journal | Clinical Neurophysiology |
| Volume | 130 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 1 2019 |
Fingerprint
Keywords
- Alzheimer's disease (AD)
- Exact low-resolution brain electromagnetic source tomography (eLORETA)
- Modafinil
- Resting state electroencephalographic (rsEEG) rhythms
- Sleep deprivation
ASJC Scopus subject areas
- Sensory Systems
- Neurology
- Clinical Neurology
- Physiology (medical)
Cite this
Sleep deprivation and Modafinil affect cortical sources of resting state electroencephalographic rhythms in healthy young adults. / Del Percio, Claudio; Derambure, Philippe; Noce, Giuseppe; Lizio, Roberta; Faz, David Bartrés; Blin, Olivier; Payoux, Pierre; Deplanque, Dominique; Méligne, Déborah; Chauveau, Nicolas; Bourriez, Jean Louis; Casse-Perrot, Catherine; Lanteaume, L.; Thalamas, Claire; Dukart, Juergen; Ferri, Raffaele; Pascarelli, Maria Teresa; Richardson, Jill C.; Bordet, R.; Babiloni, Claudio.
In: Clinical Neurophysiology, Vol. 130, No. 9, 01.09.2019, p. 1488-1498.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sleep deprivation and Modafinil affect cortical sources of resting state electroencephalographic rhythms in healthy young adults
AU - Del Percio, Claudio
AU - Derambure, Philippe
AU - Noce, Giuseppe
AU - Lizio, Roberta
AU - Faz, David Bartrés
AU - Blin, Olivier
AU - Payoux, Pierre
AU - Deplanque, Dominique
AU - Méligne, Déborah
AU - Chauveau, Nicolas
AU - Bourriez, Jean Louis
AU - Casse-Perrot, Catherine
AU - Lanteaume, L.
AU - Thalamas, Claire
AU - Dukart, Juergen
AU - Ferri, Raffaele
AU - Pascarelli, Maria Teresa
AU - Richardson, Jill C.
AU - Bordet, R.
AU - Babiloni, Claudio
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Objective: It has been reported that sleep deprivation affects the neurophysiological mechanisms underpinning the vigilance. Here, we tested the following hypotheses in the PharmaCog project (www.pharmacog.org): (i) sleep deprivation may alter posterior cortical delta and alpha sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms in healthy young adults; (ii) after the sleep deprivation, a vigilance enhancer may recover those rsEEG source markers. Methods: rsEEG data were recorded in 36 healthy young adults before (Pre-sleep deprivation) and after (Post-sleep deprivation) one night of sleep deprivation. In the Post-sleep deprivation, these data were collected after a single dose of PLACEBO or MODAFINIL. rsEEG cortical sources were estimated by eLORETA freeware. Results: In the PLACEBO condition, the sleep deprivation induced an increase and a decrease in posterior delta (2–4 Hz) and alpha (8–13 Hz) source activities, respectively. In the MODAFINIL condition, the vigilance enhancer partially recovered those source activities. Conclusions: The present results suggest that posterior delta and alpha source activities may be both related to the regulation of human brain arousal and vigilance in quiet wakefulness. Significance: Future research in healthy young adults may use this methodology to preselect new symptomatic drug candidates designed to normalize brain arousal and vigilance in seniors with dementia.
AB - Objective: It has been reported that sleep deprivation affects the neurophysiological mechanisms underpinning the vigilance. Here, we tested the following hypotheses in the PharmaCog project (www.pharmacog.org): (i) sleep deprivation may alter posterior cortical delta and alpha sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms in healthy young adults; (ii) after the sleep deprivation, a vigilance enhancer may recover those rsEEG source markers. Methods: rsEEG data were recorded in 36 healthy young adults before (Pre-sleep deprivation) and after (Post-sleep deprivation) one night of sleep deprivation. In the Post-sleep deprivation, these data were collected after a single dose of PLACEBO or MODAFINIL. rsEEG cortical sources were estimated by eLORETA freeware. Results: In the PLACEBO condition, the sleep deprivation induced an increase and a decrease in posterior delta (2–4 Hz) and alpha (8–13 Hz) source activities, respectively. In the MODAFINIL condition, the vigilance enhancer partially recovered those source activities. Conclusions: The present results suggest that posterior delta and alpha source activities may be both related to the regulation of human brain arousal and vigilance in quiet wakefulness. Significance: Future research in healthy young adults may use this methodology to preselect new symptomatic drug candidates designed to normalize brain arousal and vigilance in seniors with dementia.
KW - Alzheimer's disease (AD)
KW - Exact low-resolution brain electromagnetic source tomography (eLORETA)
KW - Modafinil
KW - Resting state electroencephalographic (rsEEG) rhythms
KW - Sleep deprivation
UR - http://www.scopus.com/inward/record.url?scp=85068465488&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85068465488&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2019.06.007
DO - 10.1016/j.clinph.2019.06.007
M3 - Article
AN - SCOPUS:85068465488
VL - 130
SP - 1488
EP - 1498
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 9
ER -