Sleep disordered breathing in renal transplant patients

F. Mallamaci, D. Leonardis, R. Tripepi, G. Parlongo, C. Catalano, G. Tripepi, V. Castronovo, L. Ferini-Strambi, C. Zoccali

Research output: Contribution to journalArticle

Abstract

Sleep disordered breathing (SDB) is a prevalent, important nontraditional cardiovascular (CV) risk factor in end-stage renal disease patients. The prevalence of SDB in renal transplant patients is unknown. We compared polysomnographic studies in 163 transplant patients with matched samples in the general population and explored longitudinally the effect of return to dialysis after graft failure on SDB in three consecutive cases. Episodes of nocturnal hypoxemia, average and minimal O2 saturation overnight in transplant patients did not differ from those in individuals in the general population matched for age, gender and body mass index (BMI). The prevalence of moderate-to-severe SBD in these patients did not exceed the estimated prevalence of the same disturbance in the general population. The respiratory disturbance index in transplant patients was directly associated with BMI (p <0.001). In the longitudinal study all indicators of SDB coherently increased after transplant failure. The prevalence of SDB in transplant patients does not differ from that in well-matched individuals in the general population. The favorable effect of renal transplantation on CV risk may be at least partially explained by the lack of risk excess for SDB in this population. Longitudinal observations after transplant failure are compatible with the hypothesis that renal transplantation reverses SDB.

Original languageEnglish
Pages (from-to)1373-1381
Number of pages9
JournalAmerican Journal of Transplantation
Volume9
Issue number6
DOIs
Publication statusPublished - Jun 2009

Keywords

  • Cardiovascular risk
  • ESRD
  • Renal transplantation
  • Reversibility
  • Sleep apnea
  • Uremia

ASJC Scopus subject areas

  • Transplantation
  • Immunology and Allergy
  • Pharmacology (medical)

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    Mallamaci, F., Leonardis, D., Tripepi, R., Parlongo, G., Catalano, C., Tripepi, G., Castronovo, V., Ferini-Strambi, L., & Zoccali, C. (2009). Sleep disordered breathing in renal transplant patients. American Journal of Transplantation, 9(6), 1373-1381. https://doi.org/10.1111/j.1600-6143.2009.02653.x