Sleep disorders in myotonic dystrophy type 2: A controlled polysomnographic study and self-reported questionnaires

A. Romigi, M. Albanese, F. Placidi, F. Izzi, C. Liguori, M. G. Marciani, N. B. Mercuri, C. Terracciano, G. Vitrani, A. Petrucci, B. Di Gioia, R. Massa

Research output: Contribution to journalArticlepeer-review

Abstract

Background and purpose: There is a paucity of data available regarding the occurrence of sleep disorders in myotonic dystrophy type 2 (DM2). In this study the sleep-wake cycle and daytime sleepiness were investigated in DM2 patients and compared with results from healthy subjects and myotonic dystrophy type 1 (DM1) patients. Methods: Twelve DM2 outpatients, 12 age- and sex-matched healthy controls and 18 DM1 patients were recruited. Subjective quality of sleep was assessed by means of the Pittsburgh Sleep Quality Index (PSQI). Both the Epworth Sleepiness Scale and the Daytime Sleepiness Scale were performed in order to evaluate excessive daytime sleepiness (EDS). All participants underwent polysomnographic monitoring over 48 h as well as the Multiple Sleep Latency Test. Results: Sleep efficiency was <90% in 12/12 DM2 patients, and significantly reduced when compared with controls or with DM1. Decreased sleep efficiency was associated with sleep-disordered breathing in seven out of 12 DM2 patients and/or periodic limbs movements of sleep (PLMS) in three out of eight patients. Six DM2 patients showed REM sleep without atonia, whereas none of the controls or DM1 patients showed REM sleep dysregulation. The global PSQI score was higher in DM2 patients than in controls and DM1 patients. Conclusions: Sleep quality in DM2 patients is poorer than in DM1 patients and controls. Sleep apnea is the most common sleep disorder in DM2 patients. Obstructive sleep apnea and sleep fragmentation may represent the main cause of EDS, whereas PLMS is a frequent finding in DM1.

Original languageEnglish
Pages (from-to)929-934
Number of pages6
JournalEuropean Journal of Neurology
Volume21
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • Excessive daytime somnolence
  • Multiple sleep latency test
  • Myotonic dystrophy
  • REM sleep

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

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