Sleep disorders in spinal and bulbar muscular atrophy (Kennedy's disease): A controlled polysomnographic and self-reported questionnaires study

Andrea Romigi, Claudio Liguori, Fabio Placidi, Maria Albanese, Francesca Izzi, Elisabetta Uasone, Chiara Terracciano, Maria Grazia Marciani, Nicola Biagio Mercuri, Raffaella Ludovisi, Roberto Massa

Research output: Contribution to journalArticle

Abstract

No data are available regarding the occurrence of sleep disorders in spinal and bulbar muscular atrophy (SBMA). We investigated the sleep-wake cycle in SBMA patients compared with healthy subjects. Nine SBMA outpatients and nine age-matched and sex-matched healthy controls were evaluated. Subjective quality of sleep was assessed by means of the Pittsburgh Sleep Quality Index (PSQI). The Epworth Sleepiness Scale was used in order to evaluate excessive daytime sleepiness. All participants underwent a 48-h polysomnography followed by the multiple sleep latency test. Time in bed, total sleep time and sleep efficiency were significantly lower in SBMA than controls. Furthermore, the apnea-hypopnea index (AHI) was significantly higher in SBMA than controls. Obstructive sleep apnea (OSA: AHI >5/h) was evident in 6/9 patients (66.6 %). REM sleep without atonia was evident in three patients also affected by OSA and higher AHI in REM; 2/9 (22.2 %) SBMA patients showed periodic limb movements in sleep. The global PSQI score was higher in SBMA versus controls. Sleep quality in SBMA is poorer than in controls. OSA is the most common sleep disorder in SBMA. The sleep impairment could be induced both by OSA or/and the neurodegenerative processes involving crucial areas regulating the sleep-wake cycle.

Original languageEnglish
Pages (from-to)889-893
Number of pages5
JournalJournal of Neurology
Volume261
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • Daytime sleepiness
  • MSLT
  • Polysomnography
  • REM sleep without atonia
  • Sleep disordered breathing
  • Spinal and bulbar muscular atrophy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

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