Sleep disorders in spinal muscular atrophy

Maria C. Pera, Maria C. Pera, Domenico M. Romeo, Alessandra Graziano, Alessandra Graziano, Concetta Palermo, Concetta Palermo, Sonia Messina, Giovanni Baranello, Giorgia Coratti, Giorgia Coratti, Maria Massaro, Maria Massaro, Serena Sivo, Serena Sivo, Maria Teresa Arnoldi, Elena S. Mazzone, Elena S. Mazzone, Laura Antonaci, Laura AntonaciLeonardo Lapenta, Leonardo Lapenta, Emilio Albamonte, Emilio Albamonte, Lavinia Fanelli, Lavinia Fanelli, Roberto de Sanctis, Roberto de Sanctis, Gian Luca Vita, Maria Sframeli, Marika Pane, Marika Pane, Eugenio Mercuri, Eugenio Mercuri

Research output: Contribution to journalArticle

Abstract

© 2016 Objective To estimate the frequency of sleep disorders in young persons with type 2 and type 3 spinal muscular atrophy (SMA), and to evaluate the relationship between sleep disorders and different variables such as motor impairment, age, use of ventilation, and use of night orthoses. Methods A total of 85 young persons (6–25 years of age) with type 2 and type 3 SMA were assessed using the Sleep Disturbance Scale for Children (SDSC), a scale assessing different sleep factors, and the Hammersmith Functional Motor Scale Expanded (HFMSE), a scale evaluating motor impairment. Results An abnormal total sleep score was found in 16.4% of children with SMA; an additional 16.7% had an abnormal score on at least one of the sleep factors assessed by the SDSC. No specific correlation was observed between sleep disturbances and functional level as expressed by the SDSC and total HFMSE scores, but the relationship with individual items on the scale was different. The SDSC total score was significantly associated with the ability to half roll on both sides and to roll from prone to supine on the HMFSE. Conclusion Our results demonstrate that sleep disorders are common in children with SMA.
Original languageEnglish
Pages (from-to)160-163
Number of pages4
JournalSleep Medicine
Volume30
DOIs
Publication statusPublished - Feb 1 2017

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Spinal Muscular Atrophy
Sleep
Spinal Muscular Atrophies of Childhood
Orthotic Devices
Aptitude
Sleep Wake Disorders
Ventilation

Keywords

  • HFMSE
  • Motor function
  • SDSC
  • Sleep
  • Spinal muscular atrophy

Cite this

Pera, M. C., Pera, M. C., Romeo, D. M., Graziano, A., Graziano, A., Palermo, C., ... Mercuri, E. (2017). Sleep disorders in spinal muscular atrophy. Sleep Medicine, 30, 160-163. https://doi.org/10.1016/j.sleep.2016.11.012

Sleep disorders in spinal muscular atrophy. / Pera, Maria C.; Pera, Maria C.; Romeo, Domenico M.; Graziano, Alessandra; Graziano, Alessandra; Palermo, Concetta; Palermo, Concetta; Messina, Sonia; Baranello, Giovanni; Coratti, Giorgia; Coratti, Giorgia; Massaro, Maria; Massaro, Maria; Sivo, Serena; Sivo, Serena; Arnoldi, Maria Teresa; Mazzone, Elena S.; Mazzone, Elena S.; Antonaci, Laura; Antonaci, Laura; Lapenta, Leonardo; Lapenta, Leonardo; Albamonte, Emilio; Albamonte, Emilio; Fanelli, Lavinia; Fanelli, Lavinia; de Sanctis, Roberto; de Sanctis, Roberto; Vita, Gian Luca; Sframeli, Maria; Pane, Marika; Pane, Marika; Mercuri, Eugenio; Mercuri, Eugenio.

In: Sleep Medicine, Vol. 30, 01.02.2017, p. 160-163.

Research output: Contribution to journalArticle

Pera, MC, Pera, MC, Romeo, DM, Graziano, A, Graziano, A, Palermo, C, Palermo, C, Messina, S, Baranello, G, Coratti, G, Coratti, G, Massaro, M, Massaro, M, Sivo, S, Sivo, S, Arnoldi, MT, Mazzone, ES, Mazzone, ES, Antonaci, L, Antonaci, L, Lapenta, L, Lapenta, L, Albamonte, E, Albamonte, E, Fanelli, L, Fanelli, L, de Sanctis, R, de Sanctis, R, Vita, GL, Sframeli, M, Pane, M, Pane, M, Mercuri, E & Mercuri, E 2017, 'Sleep disorders in spinal muscular atrophy', Sleep Medicine, vol. 30, pp. 160-163. https://doi.org/10.1016/j.sleep.2016.11.012
Pera MC, Pera MC, Romeo DM, Graziano A, Graziano A, Palermo C et al. Sleep disorders in spinal muscular atrophy. Sleep Medicine. 2017 Feb 1;30:160-163. https://doi.org/10.1016/j.sleep.2016.11.012
Pera, Maria C. ; Pera, Maria C. ; Romeo, Domenico M. ; Graziano, Alessandra ; Graziano, Alessandra ; Palermo, Concetta ; Palermo, Concetta ; Messina, Sonia ; Baranello, Giovanni ; Coratti, Giorgia ; Coratti, Giorgia ; Massaro, Maria ; Massaro, Maria ; Sivo, Serena ; Sivo, Serena ; Arnoldi, Maria Teresa ; Mazzone, Elena S. ; Mazzone, Elena S. ; Antonaci, Laura ; Antonaci, Laura ; Lapenta, Leonardo ; Lapenta, Leonardo ; Albamonte, Emilio ; Albamonte, Emilio ; Fanelli, Lavinia ; Fanelli, Lavinia ; de Sanctis, Roberto ; de Sanctis, Roberto ; Vita, Gian Luca ; Sframeli, Maria ; Pane, Marika ; Pane, Marika ; Mercuri, Eugenio ; Mercuri, Eugenio. / Sleep disorders in spinal muscular atrophy. In: Sleep Medicine. 2017 ; Vol. 30. pp. 160-163.
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AU - Pera, Maria C.

AU - Romeo, Domenico M.

AU - Graziano, Alessandra

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AU - Messina, Sonia

AU - Baranello, Giovanni

AU - Coratti, Giorgia

AU - Coratti, Giorgia

AU - Massaro, Maria

AU - Massaro, Maria

AU - Sivo, Serena

AU - Sivo, Serena

AU - Arnoldi, Maria Teresa

AU - Mazzone, Elena S.

AU - Mazzone, Elena S.

AU - Antonaci, Laura

AU - Antonaci, Laura

AU - Lapenta, Leonardo

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AU - Albamonte, Emilio

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AU - Fanelli, Lavinia

AU - Fanelli, Lavinia

AU - de Sanctis, Roberto

AU - de Sanctis, Roberto

AU - Vita, Gian Luca

AU - Sframeli, Maria

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AU - Mercuri, Eugenio

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N2 - © 2016 Objective To estimate the frequency of sleep disorders in young persons with type 2 and type 3 spinal muscular atrophy (SMA), and to evaluate the relationship between sleep disorders and different variables such as motor impairment, age, use of ventilation, and use of night orthoses. Methods A total of 85 young persons (6–25 years of age) with type 2 and type 3 SMA were assessed using the Sleep Disturbance Scale for Children (SDSC), a scale assessing different sleep factors, and the Hammersmith Functional Motor Scale Expanded (HFMSE), a scale evaluating motor impairment. Results An abnormal total sleep score was found in 16.4% of children with SMA; an additional 16.7% had an abnormal score on at least one of the sleep factors assessed by the SDSC. No specific correlation was observed between sleep disturbances and functional level as expressed by the SDSC and total HFMSE scores, but the relationship with individual items on the scale was different. The SDSC total score was significantly associated with the ability to half roll on both sides and to roll from prone to supine on the HMFSE. Conclusion Our results demonstrate that sleep disorders are common in children with SMA.

AB - © 2016 Objective To estimate the frequency of sleep disorders in young persons with type 2 and type 3 spinal muscular atrophy (SMA), and to evaluate the relationship between sleep disorders and different variables such as motor impairment, age, use of ventilation, and use of night orthoses. Methods A total of 85 young persons (6–25 years of age) with type 2 and type 3 SMA were assessed using the Sleep Disturbance Scale for Children (SDSC), a scale assessing different sleep factors, and the Hammersmith Functional Motor Scale Expanded (HFMSE), a scale evaluating motor impairment. Results An abnormal total sleep score was found in 16.4% of children with SMA; an additional 16.7% had an abnormal score on at least one of the sleep factors assessed by the SDSC. No specific correlation was observed between sleep disturbances and functional level as expressed by the SDSC and total HFMSE scores, but the relationship with individual items on the scale was different. The SDSC total score was significantly associated with the ability to half roll on both sides and to roll from prone to supine on the HMFSE. Conclusion Our results demonstrate that sleep disorders are common in children with SMA.

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