TY - CHAP
T1 - Sleep in prenatally restraint stressed rats, a model of mixed anxiety-depressive disorder
AU - Mairesse, Jérôme
AU - Van Camp, Gilles
AU - Gatta, Eleonora
AU - Marrocco, Jordan
AU - Reynaert, Marie Line
AU - Consolazione, Michol
AU - Morley-Fletcher, Sara
AU - Nicoletti, Ferdinando
AU - Maccari, Stefania
PY - 2015
Y1 - 2015
N2 - Prenatal restraint stress (PRS) can induce persisting changes in individual’s development. PRS increases anxiety and depression-like behaviors and induces changes in the hypothalamo–pituitary–adrenal (HPA) axis in adult PRS rats after exposure to stress. Since adaptive capabilities also depend on temporal organization and synchronization with the external environment, we studied the effects of PRS on circadian rhythms, including the sleep–wake cycle, that are parameters altered in depression. Using a restraint stress during gestation, we showed that PRS induced phase advances in hormonal/behavioral circadian rhythms in adult rats, and an increase in the amount of paradoxical sleep, positively correlated to plasma corticosterone levels. Plasma corticosterone levels were also correlated with immobility in the forced swimming test, indicating a depressive-like profile in the PRS rats. We observed comorbidity with anxiety-like profile on PRS rats that was correlated with a reduced release of glutamate in the ventral hippocampus. Pharmacological approaches aimed at modulating glutamate release may represent a novel therapeutic strategy to treat stress-related disorders. Finally, since depressed patients exhibit changes in HPA axis activity and in circadian rhythmicity as well as in the paradoxical sleep regulation, we suggest that PRS could represent an original animal model of depression.
AB - Prenatal restraint stress (PRS) can induce persisting changes in individual’s development. PRS increases anxiety and depression-like behaviors and induces changes in the hypothalamo–pituitary–adrenal (HPA) axis in adult PRS rats after exposure to stress. Since adaptive capabilities also depend on temporal organization and synchronization with the external environment, we studied the effects of PRS on circadian rhythms, including the sleep–wake cycle, that are parameters altered in depression. Using a restraint stress during gestation, we showed that PRS induced phase advances in hormonal/behavioral circadian rhythms in adult rats, and an increase in the amount of paradoxical sleep, positively correlated to plasma corticosterone levels. Plasma corticosterone levels were also correlated with immobility in the forced swimming test, indicating a depressive-like profile in the PRS rats. We observed comorbidity with anxiety-like profile on PRS rats that was correlated with a reduced release of glutamate in the ventral hippocampus. Pharmacological approaches aimed at modulating glutamate release may represent a novel therapeutic strategy to treat stress-related disorders. Finally, since depressed patients exhibit changes in HPA axis activity and in circadian rhythmicity as well as in the paradoxical sleep regulation, we suggest that PRS could represent an original animal model of depression.
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U2 - 10.1007/978-1-4939-1372-5_2
DO - 10.1007/978-1-4939-1372-5_2
M3 - Chapter
AN - SCOPUS:84945194375
VL - 10
T3 - Advances in Neurobiology
SP - 27
EP - 44
BT - Advances in Neurobiology
PB - Springer New York LLC
ER -