Sleep in presenile dementia

S. Smirne, G. Comi, M. Franceschi

Research output: Contribution to journalArticlepeer-review

Abstract

All night polygraphic recordings were carried out on 7 patients affected by presenile dementia. On the basis of sleep organization the patients could be classified into 3 groups. In the 1st group, including 2 cases of Alzheimer's disease and one of Pick's disease, the sleep was monophasic or biphasic. Vertex sharp transients, K complexes and spindles were completely absent. It was possible to distinguish REM sleep from NREM sleep only by means of polygraphic data. This sleep was correlated with a slow EEG background activity in the waking state and with the lowest IQ on the WAIS. The 2nd group, including 2 cases of Alzheimer's disease, presented sleep stages and cycles, but vertex sharp transients, K complexes and especially spindles were markedly less numerous than in normal subjects. Alpha rhythm was at 8 Hz and IQ was 62 and 69 respectively. The 3rd group, including 2 patients without a classic pattern of mental deterioration, was characterized by the presence of sleep stages and cycles, but the phasic phenomena of NREM sleep were very rare. Alpha rhythm was at 9 and 10 Hz respectively. EEG activity both in the waking state and during sleep was of low amplitude. IQ was 77 and 78 respectively. It may be concluded that in cases of classic presenile dementia the disorganization of sleep correlates with slowing of EEG activity in the waking state and with the severity of mental deterioration. Not completely clear is the significance of EEG changes in cases of presenile dementia atypical at the time of study.

Original languageEnglish
JournalElectroencephalography and Clinical Neurophysiology
Volume43
Issue number4
DOIs
Publication statusPublished - 1977

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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