Sleep neurophysiology in fragile X patients

S. A. Musumeci, R. Ferri, M. Elia, S. Dal Gracco, C. Scuderi, M. C. Stefanini, A. Castano, G. Azan

Research output: Contribution to journalArticle


Neurophysiological and neurochemical mechanisms underlying mental retardation and behavioral and emotional problems in the fragile X (fraX) syndrome are still poorly understood. In this study, the authors evaluated the sleep characteristics of a group of 9 fraX boys in order to obtain information on their neurophysiological mechanisms. A reduction in total sleep time and rapid eye movement (REM) sleep was found in the fraX patients together with an increase in the first REM latency. Slow-wave sleep was found to be increased. Moreover, an increase in twitch movements was also observed during REM sleep. A dysregulation of the cholinergic-monoaminergic system during sleep is hypothesized to occur in the fraX syndrome.

Original languageEnglish
Pages (from-to)218-222
Number of pages5
JournalDevelopmental Brain Dysfunction
Issue number4-6
Publication statusPublished - 1995



  • fragile X syndrome
  • mental retardation
  • neurophysiology
  • sleep

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Musumeci, S. A., Ferri, R., Elia, M., Dal Gracco, S., Scuderi, C., Stefanini, M. C., Castano, A., & Azan, G. (1995). Sleep neurophysiology in fragile X patients. Developmental Brain Dysfunction, 8(4-6), 218-222.