Abstract
Neurophysiological and neurochemical mechanisms underlying mental retardation and behavioral and emotional problems in the fragile X (fraX) syndrome are still poorly understood. In this study, the authors evaluated the sleep characteristics of a group of 9 fraX boys in order to obtain information on their neurophysiological mechanisms. A reduction in total sleep time and rapid eye movement (REM) sleep was found in the fraX patients together with an increase in the first REM latency. Slow-wave sleep was found to be increased. Moreover, an increase in twitch movements was also observed during REM sleep. A dysregulation of the cholinergic-monoaminergic system during sleep is hypothesized to occur in the fraX syndrome.
| Original language | English |
|---|---|
| Pages (from-to) | 218-222 |
| Number of pages | 5 |
| Journal | Developmental Brain Dysfunction |
| Volume | 8 |
| Issue number | 4-6 |
| Publication status | Published - 1995 |
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Keywords
- fragile X syndrome
- mental retardation
- neurophysiology
- sleep
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Musumeci, S. A., Ferri, R., Elia, M., Dal Gracco, S., Scuderi, C., Stefanini, M. C., Castano, A., & Azan, G. (1995). Sleep neurophysiology in fragile X patients. Developmental Brain Dysfunction, 8(4-6), 218-222.