Abstract
Objective: We assessed sleep patterns in 85 patients with chronic disorders of consciousness (DOC) in order to reveal any relationship with the degree of the impairment. Methods: Nocturnal polysomnography (PSG) was scored in patients classified as being in an unresponsive wakefulness syndrome/vegetative state (UWS/VS; n = 49) or a minimally conscious state (MCS; n = 36) in accordance with the rules of the American Academy of Sleep Medicine. The PSG data in the two diagnostic groups were compared, and the PSG parameters associated with the degree of impairment were analysed. Results: In 19/49 UWS/VS patients, signal attenuation was the only EEG pattern detectable in sleep. Non-REM 2 (NREM2) and slow-wave sleep (SWS) (but not REM) stages were more frequent in the MCS patients. The presence of SWS was the most appropriate factor for classifying patients as UWS/VS or MCS, and the duration of SWS was the main factor that significantly correlated with revised Coma Recovery Scale scores. Conclusion: The presence of NREM sleep (namely SWS) reflects better preservation of the circuitry and structures needed to sustain this stage of sleep in DOC patients. Significance: PSG is a simple and effective technique, and sleep patterns may reflect the degree of impairment in chronic DOC patients.
| Original language | English |
|---|---|
| Pages (from-to) | 687-693 |
| Number of pages | 7 |
| Journal | Clinical Neurophysiology |
| Volume | 129 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 1 2018 |
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Keywords
- Minimally conscious state
- Polysomnography
- Sleep
- Unresponsive wakefulness syndrome
- Vegetative state
ASJC Scopus subject areas
- Sensory Systems
- Neurology
- Clinical Neurology
- Physiology (medical)
Cite this
Sleep patterns associated with the severity of impairment in a large cohort of patients with chronic disorders of consciousness. / Rossi Sebastiano, Davide; Visani, Elisa; Panzica, Ferruccio; Sattin, Davide; Bersano, Anna; Nigri, Anna; Ferraro, Stefania; Parati, Eugenio; Leonardi, Matilde; Franceschetti, Silvana.
In: Clinical Neurophysiology, Vol. 129, No. 3, 01.03.2018, p. 687-693.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sleep patterns associated with the severity of impairment in a large cohort of patients with chronic disorders of consciousness
AU - Rossi Sebastiano, Davide
AU - Visani, Elisa
AU - Panzica, Ferruccio
AU - Sattin, Davide
AU - Bersano, Anna
AU - Nigri, Anna
AU - Ferraro, Stefania
AU - Parati, Eugenio
AU - Leonardi, Matilde
AU - Franceschetti, Silvana
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Objective: We assessed sleep patterns in 85 patients with chronic disorders of consciousness (DOC) in order to reveal any relationship with the degree of the impairment. Methods: Nocturnal polysomnography (PSG) was scored in patients classified as being in an unresponsive wakefulness syndrome/vegetative state (UWS/VS; n = 49) or a minimally conscious state (MCS; n = 36) in accordance with the rules of the American Academy of Sleep Medicine. The PSG data in the two diagnostic groups were compared, and the PSG parameters associated with the degree of impairment were analysed. Results: In 19/49 UWS/VS patients, signal attenuation was the only EEG pattern detectable in sleep. Non-REM 2 (NREM2) and slow-wave sleep (SWS) (but not REM) stages were more frequent in the MCS patients. The presence of SWS was the most appropriate factor for classifying patients as UWS/VS or MCS, and the duration of SWS was the main factor that significantly correlated with revised Coma Recovery Scale scores. Conclusion: The presence of NREM sleep (namely SWS) reflects better preservation of the circuitry and structures needed to sustain this stage of sleep in DOC patients. Significance: PSG is a simple and effective technique, and sleep patterns may reflect the degree of impairment in chronic DOC patients.
AB - Objective: We assessed sleep patterns in 85 patients with chronic disorders of consciousness (DOC) in order to reveal any relationship with the degree of the impairment. Methods: Nocturnal polysomnography (PSG) was scored in patients classified as being in an unresponsive wakefulness syndrome/vegetative state (UWS/VS; n = 49) or a minimally conscious state (MCS; n = 36) in accordance with the rules of the American Academy of Sleep Medicine. The PSG data in the two diagnostic groups were compared, and the PSG parameters associated with the degree of impairment were analysed. Results: In 19/49 UWS/VS patients, signal attenuation was the only EEG pattern detectable in sleep. Non-REM 2 (NREM2) and slow-wave sleep (SWS) (but not REM) stages were more frequent in the MCS patients. The presence of SWS was the most appropriate factor for classifying patients as UWS/VS or MCS, and the duration of SWS was the main factor that significantly correlated with revised Coma Recovery Scale scores. Conclusion: The presence of NREM sleep (namely SWS) reflects better preservation of the circuitry and structures needed to sustain this stage of sleep in DOC patients. Significance: PSG is a simple and effective technique, and sleep patterns may reflect the degree of impairment in chronic DOC patients.
KW - Minimally conscious state
KW - Polysomnography
KW - Sleep
KW - Unresponsive wakefulness syndrome
KW - Vegetative state
UR - http://www.scopus.com/inward/record.url?scp=85039919967&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85039919967&partnerID=8YFLogxK
U2 - 10.1016/j.clinph.2017.12.012
DO - 10.1016/j.clinph.2017.12.012
M3 - Article
C2 - 29307451
AN - SCOPUS:85039919967
VL - 129
SP - 687
EP - 693
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 3
ER -