Sleep patterns of Down's syndrome children: Effects of butoctamide hydrogen succinate (BAHS) administration

J. C. Grubar, G. L. Gigli, R. M. Colognola, R. Ferri, S. A. Musumeci, P. Bergonzi

Research output: Contribution to journalArticlepeer-review

Abstract

Several investigators have described the altered sleep patterns in Down's syndrome subjects. The most relevant findings have been a reduction in percentage of REM sleep, a prolonged latency to the first REM episode, an increase in undifferentiated sleep, and a reduced ratio of the oculomotor frequencies. Because it is of interest to identify new drugs able to increase the percentage of REM sleep in mentally retarded subjects, we studied the effects of butoctamide hydrogen succinate (BAHS) on nocturnal sleep in eight young institutionalized Down's syndrome subjects. BAHS produced a significant increase in the percentage of REM sleep as well as a decrease in undifferentiated sleep and latency to the first REM.

Original languageEnglish
Pages (from-to)119-122
Number of pages4
JournalPsychopharmacology
Volume90
Issue number1
DOIs
Publication statusPublished - Aug 1986

Keywords

  • BAHS
  • Down's syndrome
  • REM sleep

ASJC Scopus subject areas

  • Pharmacology

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