Sleep quality in patients with chronic renal failure: A 3-year longitudinal study

Massimo Sabbatini, Antonio Pisani, Anna Crispo, Annalisa Ragosta, Riccardo Gallo, Andrea Pota, Vittorio Serio, Giovanni Tripepi, Bruno Cianciaruso

Research output: Contribution to journalArticlepeer-review


Background: Despite the high prevalence of sleep disorders in patients with kidney disease, no relationship has been demonstrated between sleep quality and the degree of renal function in cross-sectional studies. A prospective trial was, therefore, started in patients with chronic renal failure (CRF) to evaluate whether a link exists between the modifications of these parameters observed during a three-year follow-up period. Methods: Sleep quality was determined by the Pittsburgh Sleep Quality Index (PSQI) at baseline and after two and three years (Time 0, 2 and 3, respectively) in 78 patients with various degrees of CRF in association with the main clinical and biochemical variables. Results: The baseline PSQI averaged 6.2 ± 3.8 (range: 0-21, with higher values indicating worse sleep quality) and was significantly increased at both Time 2 and 3 (8.8 ± 3.7 and 10.2 ± 3.5, respectively, P <0.0001 vs baseline), whereas creatinine clearance progressively decreased (45 ± 24 vs 41 ± 26 and 32 ± 20 ml/min, at time 0, 2 and 3, respectively, P <0.0001), although an independent association with PSQI could not be demonstrated after adjustment for confounding factors (P = 0.90, mixed linear model). Conclusions: Our data suggest that the progression of renal disease is accompanied by a progressive worsening of sleep quality; age is strongly related to both phenomena. PSQI represents an easy tool to use to detect sleep disorders and to more effectively evaluate renal patients; the prevention of sleep disorders by early and appropriate treatments could beneficially influence the course of the disease.

Original languageEnglish
Pages (from-to)240-246
Number of pages7
JournalSleep Medicine
Issue number3
Publication statusPublished - Mar 2008


  • Chronic renal failure
  • Pittsburgh questionnaire
  • PSQI
  • Sleep disorders
  • Sleep quality

ASJC Scopus subject areas

  • Ophthalmology
  • Pulmonary and Respiratory Medicine
  • Neurology
  • Dentistry(all)


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