Sleep-related breathing disorders in amyotrophic lateral sclerosis

C. Santos, A. Braghiroli, L. Mazzini, R. Pratesi, L. V. Franco Oliveira, G. Mora

Research output: Contribution to journalArticlepeer-review


Sleep-related breathing events in patients with amyotrophic lateral sclerosis (ALS) have been reported in small case series, but the association with the clinical presentation - with (B) or without (nonB) bulbar symptoms - or the relevance for prognosis have not been investigated. We retrospectively analyzed sleep studies of 114 (46 nonB) ALS patients, aged 54±11 years. Respiratory function was better in nonB patients: forced vital capacity was 76±20% vs 55±23% in the bulbar group (p2 41±5 vs 44±6 mm Hg p2yr). The occurrence of sleep-related respiratory disorders decreased with the increase of disease duration (23±15; 18±14; and 16±15 events per hour respectively), the decrease being significantly lower in the >2yr group than in the

Original languageEnglish
Pages (from-to)160-165
Number of pages6
JournalMonaldi Archives for Chest Disease - Cardiac Series
Issue number2
Publication statusPublished - Apr 2003


  • Amyotrophic lateral sclerosis
  • Oxyhemoglobin desaturations
  • Polysomnography
  • Sleep apnea

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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