Abstract
It has been hypothesized that in chronic obstructive pulmonary disease (COPD), sleep-related hypoxaemia could lead to pulmonary hypertension (PH) and cor pulmonale, eveni in patients with only mild daytime hypoxaemia. We investigated the relationships between sleep variables and daytime pulmonary haemodynamics in 40 COPD patients with daytime arterial oxygen tension (PaO2) between 60-70 mmHg (8-9.3 kPa). Patients were considered as desaturators if they spent at least 30% of the sleep recording time with a transcutaneous O2 saturation (StcO2) 2, measured just prior to the onset of sleep, was lower in group D. Pulmonary artery mean pressure was significantly higher in group D (19.1 ± 4.7 vs 16.8 ± 1.9 mmHg, p <0.05) and all patients with PH (6 out of 40) belonged to group D. PH was observed in 6 of the 15 patients whose mean nocturnal StcO2 was 2 >90%. The PH patients (n=6), all desaturators, differed from the desaturtors with no PH (n=12), and from ND (n=22) in having higher numbers of desaturation dips, longer durations of dips, and lower mean nocturnal arterial oxygen saturation (SaO2). We conclude that a causal relation between nocturnal desaturation and permanent PH is very likely. Further studies are needed to see whether oxygen therapy can prevent PH in these patients.
| Original language | English |
|---|---|
| Pages (from-to) | 301-307 |
| Number of pages | 7 |
| Journal | European Respiratory Journal |
| Volume | 5 |
| Issue number | 3 |
| Publication status | Published - 1992 |
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Keywords
- (COPD)
- Causes of pulmonary hypertension in COPD
- Chronic obstructive pulmonary disease
- Mild daytime hypoxaemia
- Pulmonary hypertension
- Sleep related hypoxaemia
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Sleep-related oxygen desaturation and daytime pulmonary haemodynamics in COPD patients. / Levi-Valensi, P.; Weitzenblum, E.; Rida, Z.; Aubry, P.; Braghiroli, A.; Donner, C.; Aprill, M.; Zielinski, J.; Wurtemberger, G.
In: European Respiratory Journal, Vol. 5, No. 3, 1992, p. 301-307.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sleep-related oxygen desaturation and daytime pulmonary haemodynamics in COPD patients
AU - Levi-Valensi, P.
AU - Weitzenblum, E.
AU - Rida, Z.
AU - Aubry, P.
AU - Braghiroli, A.
AU - Donner, C.
AU - Aprill, M.
AU - Zielinski, J.
AU - Wurtemberger, G.
PY - 1992
Y1 - 1992
N2 - It has been hypothesized that in chronic obstructive pulmonary disease (COPD), sleep-related hypoxaemia could lead to pulmonary hypertension (PH) and cor pulmonale, eveni in patients with only mild daytime hypoxaemia. We investigated the relationships between sleep variables and daytime pulmonary haemodynamics in 40 COPD patients with daytime arterial oxygen tension (PaO2) between 60-70 mmHg (8-9.3 kPa). Patients were considered as desaturators if they spent at least 30% of the sleep recording time with a transcutaneous O2 saturation (StcO2) 2, measured just prior to the onset of sleep, was lower in group D. Pulmonary artery mean pressure was significantly higher in group D (19.1 ± 4.7 vs 16.8 ± 1.9 mmHg, p <0.05) and all patients with PH (6 out of 40) belonged to group D. PH was observed in 6 of the 15 patients whose mean nocturnal StcO2 was 2 >90%. The PH patients (n=6), all desaturators, differed from the desaturtors with no PH (n=12), and from ND (n=22) in having higher numbers of desaturation dips, longer durations of dips, and lower mean nocturnal arterial oxygen saturation (SaO2). We conclude that a causal relation between nocturnal desaturation and permanent PH is very likely. Further studies are needed to see whether oxygen therapy can prevent PH in these patients.
AB - It has been hypothesized that in chronic obstructive pulmonary disease (COPD), sleep-related hypoxaemia could lead to pulmonary hypertension (PH) and cor pulmonale, eveni in patients with only mild daytime hypoxaemia. We investigated the relationships between sleep variables and daytime pulmonary haemodynamics in 40 COPD patients with daytime arterial oxygen tension (PaO2) between 60-70 mmHg (8-9.3 kPa). Patients were considered as desaturators if they spent at least 30% of the sleep recording time with a transcutaneous O2 saturation (StcO2) 2, measured just prior to the onset of sleep, was lower in group D. Pulmonary artery mean pressure was significantly higher in group D (19.1 ± 4.7 vs 16.8 ± 1.9 mmHg, p <0.05) and all patients with PH (6 out of 40) belonged to group D. PH was observed in 6 of the 15 patients whose mean nocturnal StcO2 was 2 >90%. The PH patients (n=6), all desaturators, differed from the desaturtors with no PH (n=12), and from ND (n=22) in having higher numbers of desaturation dips, longer durations of dips, and lower mean nocturnal arterial oxygen saturation (SaO2). We conclude that a causal relation between nocturnal desaturation and permanent PH is very likely. Further studies are needed to see whether oxygen therapy can prevent PH in these patients.
KW - (COPD)
KW - Causes of pulmonary hypertension in COPD
KW - Chronic obstructive pulmonary disease
KW - Mild daytime hypoxaemia
KW - Pulmonary hypertension
KW - Sleep related hypoxaemia
UR - http://www.scopus.com/inward/record.url?scp=0026516719&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026516719&partnerID=8YFLogxK
M3 - Article
C2 - 1572442
AN - SCOPUS:0026516719
VL - 5
SP - 301
EP - 307
JO - European Journal of Respiratory Diseases
JF - European Journal of Respiratory Diseases
SN - 0903-1936
IS - 3
ER -