Sleep structure in essential hypertensive patients

Differences between dippers and non-dippers

M. Pedullaa, R. Silvestri, A. Lasco, G. Mento, B. Lanuzza, L. Sofia, N. Frisina

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The objective of this study was to determine whether the macrostructure and microstructure of sleep were altered in non-dipper essential hypertensive patients. Patients included 9 non-dipper essential hypertensive patients and 10 dippers. We measured blood pressure beat-to-beat by Finapres and all stages of sleep by polysomnografically recording simultaneously during spontaneous nocturnal sleep. We analysed blood pressure pattern for 4-min long random periods while the patients were awake and during all stages of sleep; sleep-efficiency (SE), sleep-latency (SL), delta sleep-latency (dL-SL), REM sleep-latency (REM-SL), St. 1, St. 2, St. 3, St. 4 and REM duration and percentage (% values, and microtructural aspects of sleep (arousal and microarousal temporisation and features). Dipper patients showed a fall in blood pressure (BP) greater than 10% in all stages of NREM sleep; in the non-dipper patients BP fell by less than 10% of waking values in all NREM stages. REM sleep as well as HR were similar in both groups during all stages of sleep. Non-dippers showed the same number of arousals but more microarousals than dippers (p <0.001). During and after microarousals BP and HR increased in non-dippers, but showed light variation in dippers. Microarousals induced several stage shifts towards lighter sleep. For this reason non-dippers spent less time in stage 4 than dippers (p <0.001). In conclusion, non-dipper essential hypertensive patients are a subset of patients with central sympathetic hyperactivity responsible for quantitative and qualitative alteration of sleep.

Original languageEnglish
Pages (from-to)232-237
Number of pages6
JournalBlood Pressure
Volume4
Issue number4
DOIs
Publication statusPublished - 1995

Fingerprint

Sleep
Sleep Stages
Blood Pressure
REM Sleep
Arousal
Light

Keywords

  • Arousals
  • Dippers
  • Hypertension
  • Microarousals
  • Non-dippers
  • Sympathetic activity

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Sleep structure in essential hypertensive patients : Differences between dippers and non-dippers. / Pedullaa, M.; Silvestri, R.; Lasco, A.; Mento, G.; Lanuzza, B.; Sofia, L.; Frisina, N.

In: Blood Pressure, Vol. 4, No. 4, 1995, p. 232-237.

Research output: Contribution to journalArticle

Pedullaa, M, Silvestri, R, Lasco, A, Mento, G, Lanuzza, B, Sofia, L & Frisina, N 1995, 'Sleep structure in essential hypertensive patients: Differences between dippers and non-dippers', Blood Pressure, vol. 4, no. 4, pp. 232-237. https://doi.org/10.3109/08037059509077600
Pedullaa, M. ; Silvestri, R. ; Lasco, A. ; Mento, G. ; Lanuzza, B. ; Sofia, L. ; Frisina, N. / Sleep structure in essential hypertensive patients : Differences between dippers and non-dippers. In: Blood Pressure. 1995 ; Vol. 4, No. 4. pp. 232-237.
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