Abstract
The objective of this study was to determine whether the macrostructure and microstructure of sleep were altered in non-dipper essential hypertensive patients. Patients included 9 non-dipper essential hypertensive patients and 10 dippers. We measured blood pressure beat-to-beat by Finapres and all stages of sleep by polysomnografically recording simultaneously during spontaneous nocturnal sleep. We analysed blood pressure pattern for 4-min long random periods while the patients were awake and during all stages of sleep; sleep-efficiency (SE), sleep-latency (SL), delta sleep-latency (dL-SL), REM sleep-latency (REM-SL), St. 1, St. 2, St. 3, St. 4 and REM duration and percentage (% values, and microtructural aspects of sleep (arousal and microarousal temporisation and features). Dipper patients showed a fall in blood pressure (BP) greater than 10% in all stages of NREM sleep; in the non-dipper patients BP fell by less than 10% of waking values in all NREM stages. REM sleep as well as HR were similar in both groups during all stages of sleep. Non-dippers showed the same number of arousals but more microarousals than dippers (p <0.001). During and after microarousals BP and HR increased in non-dippers, but showed light variation in dippers. Microarousals induced several stage shifts towards lighter sleep. For this reason non-dippers spent less time in stage 4 than dippers (p <0.001). In conclusion, non-dipper essential hypertensive patients are a subset of patients with central sympathetic hyperactivity responsible for quantitative and qualitative alteration of sleep.
| Original language | English |
|---|---|
| Pages (from-to) | 232-237 |
| Number of pages | 6 |
| Journal | Blood Pressure |
| Volume | 4 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1995 |
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Keywords
- Arousals
- Dippers
- Hypertension
- Microarousals
- Non-dippers
- Sympathetic activity
ASJC Scopus subject areas
- Internal Medicine
- Cardiology and Cardiovascular Medicine
Cite this
Sleep structure in essential hypertensive patients : Differences between dippers and non-dippers. / Pedullaa, M.; Silvestri, R.; Lasco, A.; Mento, G.; Lanuzza, B.; Sofia, L.; Frisina, N.
In: Blood Pressure, Vol. 4, No. 4, 1995, p. 232-237.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sleep structure in essential hypertensive patients
T2 - Differences between dippers and non-dippers
AU - Pedullaa, M.
AU - Silvestri, R.
AU - Lasco, A.
AU - Mento, G.
AU - Lanuzza, B.
AU - Sofia, L.
AU - Frisina, N.
PY - 1995
Y1 - 1995
N2 - The objective of this study was to determine whether the macrostructure and microstructure of sleep were altered in non-dipper essential hypertensive patients. Patients included 9 non-dipper essential hypertensive patients and 10 dippers. We measured blood pressure beat-to-beat by Finapres and all stages of sleep by polysomnografically recording simultaneously during spontaneous nocturnal sleep. We analysed blood pressure pattern for 4-min long random periods while the patients were awake and during all stages of sleep; sleep-efficiency (SE), sleep-latency (SL), delta sleep-latency (dL-SL), REM sleep-latency (REM-SL), St. 1, St. 2, St. 3, St. 4 and REM duration and percentage (% values, and microtructural aspects of sleep (arousal and microarousal temporisation and features). Dipper patients showed a fall in blood pressure (BP) greater than 10% in all stages of NREM sleep; in the non-dipper patients BP fell by less than 10% of waking values in all NREM stages. REM sleep as well as HR were similar in both groups during all stages of sleep. Non-dippers showed the same number of arousals but more microarousals than dippers (p <0.001). During and after microarousals BP and HR increased in non-dippers, but showed light variation in dippers. Microarousals induced several stage shifts towards lighter sleep. For this reason non-dippers spent less time in stage 4 than dippers (p <0.001). In conclusion, non-dipper essential hypertensive patients are a subset of patients with central sympathetic hyperactivity responsible for quantitative and qualitative alteration of sleep.
AB - The objective of this study was to determine whether the macrostructure and microstructure of sleep were altered in non-dipper essential hypertensive patients. Patients included 9 non-dipper essential hypertensive patients and 10 dippers. We measured blood pressure beat-to-beat by Finapres and all stages of sleep by polysomnografically recording simultaneously during spontaneous nocturnal sleep. We analysed blood pressure pattern for 4-min long random periods while the patients were awake and during all stages of sleep; sleep-efficiency (SE), sleep-latency (SL), delta sleep-latency (dL-SL), REM sleep-latency (REM-SL), St. 1, St. 2, St. 3, St. 4 and REM duration and percentage (% values, and microtructural aspects of sleep (arousal and microarousal temporisation and features). Dipper patients showed a fall in blood pressure (BP) greater than 10% in all stages of NREM sleep; in the non-dipper patients BP fell by less than 10% of waking values in all NREM stages. REM sleep as well as HR were similar in both groups during all stages of sleep. Non-dippers showed the same number of arousals but more microarousals than dippers (p <0.001). During and after microarousals BP and HR increased in non-dippers, but showed light variation in dippers. Microarousals induced several stage shifts towards lighter sleep. For this reason non-dippers spent less time in stage 4 than dippers (p <0.001). In conclusion, non-dipper essential hypertensive patients are a subset of patients with central sympathetic hyperactivity responsible for quantitative and qualitative alteration of sleep.
KW - Arousals
KW - Dippers
KW - Hypertension
KW - Microarousals
KW - Non-dippers
KW - Sympathetic activity
UR - http://www.scopus.com/inward/record.url?scp=0029023085&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029023085&partnerID=8YFLogxK
U2 - 10.3109/08037059509077600
DO - 10.3109/08037059509077600
M3 - Article
C2 - 7496562
AN - SCOPUS:0029023085
VL - 4
SP - 232
EP - 237
JO - Blood Pressure
JF - Blood Pressure
SN - 0803-7051
IS - 4
ER -