Sleep-wake cycle abnormalities in fatal familial insomnia. Evidence of the role of the thalamus in sleep regulation

E. Sforza, P. Montagna, P. Tinuper, P. Cortelli, P. Avoni, F. Ferrillo, R. Petersen, P. Gambetti, E. Lugaresi

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Alterations in sleep organization were longitudinally studied in 6 new cases of fatal familial insomnia (FFI) by 24 h polygraphic recording. All patients showed an early reduction in sleep spindles and K complexes, and a drastic reduction in total sleep time and disruption of the cyclic sleep organization. Complete abolition of NREM sleep and persistence of only brief residual periods of REM sleep without atonia were features characteristic of the 3 patients with a short (less than 1 year) clinical course, and lacking in the 3 cases with a longer (more than 2 years) disease course. In the latter, sudden transitions from waking to NREM or REM sleep occurred, sometimes recurring periodically. Our findings confirm that impairment of sleep-wake regulation is a consistent distinctive feature of FFI.

Original languageEnglish
Pages (from-to)398-405
Number of pages8
JournalElectroencephalography and Clinical Neurophysiology
Volume94
Issue number6
DOIs
Publication statusPublished - 1995

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Fatal Familial Insomnia
Thalamus
Sleep
REM Sleep

Keywords

  • Dorsomedial thalamic nucleus
  • Fatal familial insomnia
  • Prion disease
  • Sleep-wake cycle

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Sleep-wake cycle abnormalities in fatal familial insomnia. Evidence of the role of the thalamus in sleep regulation. / Sforza, E.; Montagna, P.; Tinuper, P.; Cortelli, P.; Avoni, P.; Ferrillo, F.; Petersen, R.; Gambetti, P.; Lugaresi, E.

In: Electroencephalography and Clinical Neurophysiology, Vol. 94, No. 6, 1995, p. 398-405.

Research output: Contribution to journalArticle

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AU - Ferrillo, F.

AU - Petersen, R.

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