TY - JOUR
T1 - Slipped capital femoral epiphysis
T2 - An ultrastructural study before and after osteosynthesis
AU - Falciglia, Francesco
AU - Aulisa, Angelo Gabriele
AU - Giordano, Marco
AU - Boldrini, Renata
AU - Guzzanti, Vincenzo
PY - 2010/6/3
Y1 - 2010/6/3
N2 - Background and purpose Several different theories have been proposed to explain the pathogenesis of slipped capital femoral epiphysis (SCFE). Using transmission electron microscopy (TEM) we carried out an ultrastructural study of core biopsy specimens of the physis at various stages of the disease. Methods Core biopsies were performed in 6 patients with different forms of SCFE during the first operation and in 3 of them when removing the osteosynthesis material before physeal closure. The specimens were prepared for TEM examination. Results In 6 specimens obtained at first surgery a marked distortion of the physeal architecture was observed. In 2 of the 3 specimens obtained at removal of the osteosynthesis material the physis showed a more normal organization. Interpretation The improvement of the pathological alterations observed in the 2 cases after surgical intervention leads us to consider the possibility that when the growth plate is stabilized directly by pinning or indirectly by creating more optimal loading conditions with an intertrochanteric osteotomy the morpho-functional characteristics of the physis can be restored and its growth process may resume. Copyright:
AB - Background and purpose Several different theories have been proposed to explain the pathogenesis of slipped capital femoral epiphysis (SCFE). Using transmission electron microscopy (TEM) we carried out an ultrastructural study of core biopsy specimens of the physis at various stages of the disease. Methods Core biopsies were performed in 6 patients with different forms of SCFE during the first operation and in 3 of them when removing the osteosynthesis material before physeal closure. The specimens were prepared for TEM examination. Results In 6 specimens obtained at first surgery a marked distortion of the physeal architecture was observed. In 2 of the 3 specimens obtained at removal of the osteosynthesis material the physis showed a more normal organization. Interpretation The improvement of the pathological alterations observed in the 2 cases after surgical intervention leads us to consider the possibility that when the growth plate is stabilized directly by pinning or indirectly by creating more optimal loading conditions with an intertrochanteric osteotomy the morpho-functional characteristics of the physis can be restored and its growth process may resume. Copyright:
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U2 - 10.3109/17453674.2010.483987
DO - 10.3109/17453674.2010.483987
M3 - Article
C2 - 20443746
AN - SCOPUS:77952854643
VL - 81
SP - 331
EP - 336
JO - Acta Orthopaedica
JF - Acta Orthopaedica
SN - 1745-3674
IS - 3
ER -