SLN melanoma micrometastasis predictivity of nodal status

A long term retrospective study

Emilia Migliano, Barbara Bellei, Flavio Andrea Govoni, Giovanni Paolino, Caterina Catricalà, Stefania Bucher, Pietro Donati

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Completion lymph node dissection (CLND) is the gold standard treatment for patients with a positive sentinel lymph node (SLN) biopsy. Considering the morbidity associated with CLND it is important to identify histological features of the primary tumor and/or of SLN metastasis that could help to spare from CLND a subset of patients who have a very low risk of non-SLN metastasis. The objective of this study is to identify patients with a very low risk to develop non-SLNs recurrences and to limit unnecessary CLND. Methods. A retrospective long-term study of 80 melanoma patients with positive SLN, undergone CLND, was assessed to define the risk of additional metastasis in the regional nodal basin, on the basis of intranodal distribution of metastatic cells, using the micro-morphometric analysis (Starz classification). Results: This study demonstrates that among the demographic and pathologic features of primary melanoma and of SLN only the Starz classification shows prognostic significance for non-SLN status (p

Original languageEnglish
Article number47
JournalJournal of Experimental and Clinical Cancer Research
Volume32
Issue number1
DOIs
Publication statusPublished - 2013

Fingerprint

Neoplasm Micrometastasis
Lymph Node Excision
Melanoma
Retrospective Studies
Neoplasm Metastasis
Lymph Nodes
Sentinel Lymph Node Biopsy
Demography
Sentinel Lymph Node
Morbidity
Recurrence
Neoplasms

Keywords

  • CLND
  • Melanoma micrometastasis
  • Nodal status
  • Sentinel lymph node
  • SLN
  • Starz classification

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

SLN melanoma micrometastasis predictivity of nodal status : A long term retrospective study. / Migliano, Emilia; Bellei, Barbara; Govoni, Flavio Andrea; Paolino, Giovanni; Catricalà, Caterina; Bucher, Stefania; Donati, Pietro.

In: Journal of Experimental and Clinical Cancer Research, Vol. 32, No. 1, 47, 2013.

Research output: Contribution to journalArticle

@article{aac19bb507644358bd1de7aacab797f9,
title = "SLN melanoma micrometastasis predictivity of nodal status: A long term retrospective study",
abstract = "Background: Completion lymph node dissection (CLND) is the gold standard treatment for patients with a positive sentinel lymph node (SLN) biopsy. Considering the morbidity associated with CLND it is important to identify histological features of the primary tumor and/or of SLN metastasis that could help to spare from CLND a subset of patients who have a very low risk of non-SLN metastasis. The objective of this study is to identify patients with a very low risk to develop non-SLNs recurrences and to limit unnecessary CLND. Methods. A retrospective long-term study of 80 melanoma patients with positive SLN, undergone CLND, was assessed to define the risk of additional metastasis in the regional nodal basin, on the basis of intranodal distribution of metastatic cells, using the micro-morphometric analysis (Starz classification). Results: This study demonstrates that among the demographic and pathologic features of primary melanoma and of SLN only the Starz classification shows prognostic significance for non-SLN status (p",
keywords = "CLND, Melanoma micrometastasis, Nodal status, Sentinel lymph node, SLN, Starz classification",
author = "Emilia Migliano and Barbara Bellei and Govoni, {Flavio Andrea} and Giovanni Paolino and Caterina Catrical{\`a} and Stefania Bucher and Pietro Donati",
year = "2013",
doi = "10.1186/1756-9966-32-47",
language = "English",
volume = "32",
journal = "Journal of Experimental and Clinical Cancer Research",
issn = "0392-9078",
publisher = "BioMed Central Ltd.",
number = "1",

}

TY - JOUR

T1 - SLN melanoma micrometastasis predictivity of nodal status

T2 - A long term retrospective study

AU - Migliano, Emilia

AU - Bellei, Barbara

AU - Govoni, Flavio Andrea

AU - Paolino, Giovanni

AU - Catricalà, Caterina

AU - Bucher, Stefania

AU - Donati, Pietro

PY - 2013

Y1 - 2013

N2 - Background: Completion lymph node dissection (CLND) is the gold standard treatment for patients with a positive sentinel lymph node (SLN) biopsy. Considering the morbidity associated with CLND it is important to identify histological features of the primary tumor and/or of SLN metastasis that could help to spare from CLND a subset of patients who have a very low risk of non-SLN metastasis. The objective of this study is to identify patients with a very low risk to develop non-SLNs recurrences and to limit unnecessary CLND. Methods. A retrospective long-term study of 80 melanoma patients with positive SLN, undergone CLND, was assessed to define the risk of additional metastasis in the regional nodal basin, on the basis of intranodal distribution of metastatic cells, using the micro-morphometric analysis (Starz classification). Results: This study demonstrates that among the demographic and pathologic features of primary melanoma and of SLN only the Starz classification shows prognostic significance for non-SLN status (p

AB - Background: Completion lymph node dissection (CLND) is the gold standard treatment for patients with a positive sentinel lymph node (SLN) biopsy. Considering the morbidity associated with CLND it is important to identify histological features of the primary tumor and/or of SLN metastasis that could help to spare from CLND a subset of patients who have a very low risk of non-SLN metastasis. The objective of this study is to identify patients with a very low risk to develop non-SLNs recurrences and to limit unnecessary CLND. Methods. A retrospective long-term study of 80 melanoma patients with positive SLN, undergone CLND, was assessed to define the risk of additional metastasis in the regional nodal basin, on the basis of intranodal distribution of metastatic cells, using the micro-morphometric analysis (Starz classification). Results: This study demonstrates that among the demographic and pathologic features of primary melanoma and of SLN only the Starz classification shows prognostic significance for non-SLN status (p

KW - CLND

KW - Melanoma micrometastasis

KW - Nodal status

KW - Sentinel lymph node

KW - SLN

KW - Starz classification

UR - http://www.scopus.com/inward/record.url?scp=84880879325&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880879325&partnerID=8YFLogxK

U2 - 10.1186/1756-9966-32-47

DO - 10.1186/1756-9966-32-47

M3 - Article

VL - 32

JO - Journal of Experimental and Clinical Cancer Research

JF - Journal of Experimental and Clinical Cancer Research

SN - 0392-9078

IS - 1

M1 - 47

ER -