SLN melanoma micrometastasis predictivity of nodal status: A long term retrospective study

Emilia Migliano, Barbara Bellei, Flavio Andrea Govoni, Giovanni Paolino, Caterina Catricalà, Stefania Bucher, Pietro Donati

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Background: Completion lymph node dissection (CLND) is the gold standard treatment for patients with a positive sentinel lymph node (SLN) biopsy. Considering the morbidity associated with CLND it is important to identify histological features of the primary tumor and/or of SLN metastasis that could help to spare from CLND a subset of patients who have a very low risk of non-SLN metastasis. The objective of this study is to identify patients with a very low risk to develop non-SLNs recurrences and to limit unnecessary CLND. Methods. A retrospective long-term study of 80 melanoma patients with positive SLN, undergone CLND, was assessed to define the risk of additional metastasis in the regional nodal basin, on the basis of intranodal distribution of metastatic cells, using the micro-morphometric analysis (Starz classification). Results: This study demonstrates that among the demographic and pathologic features of primary melanoma and of SLN only the Starz classification shows prognostic significance for non-SLN status (p

Original languageEnglish
Article number47
JournalJournal of Experimental and Clinical Cancer Research
Issue number1
Publication statusPublished - 2013



  • CLND
  • Melanoma micrometastasis
  • Nodal status
  • Sentinel lymph node
  • SLN
  • Starz classification

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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