Slow breathing improves arterial baroreflex sensitivity and decreases blood pressure in essential hypertension

Chacko N. Joseph, Cesare Porta, Gaia Casucci, Nadia Casiraghi, Mara Maffeis, Marco Rossi, Luciano Bernardi

Research output: Contribution to journalArticle

Abstract

Sympathetic hyperactivity and parasympathetic withdrawal may cause and sustain hypertension. This autonomic imbalance is in turn related to a reduced or reset arterial baroreflex sensitivity and chemoreflex-induced hyperventilation. Slow breathing at 6 breaths/min increases baroreflex sensitivity and reduces sympathetic activity and chemoreflex activation, suggesting a potentially beneficial effect in hypertension. We tested whether slow breathing was capable of modifying blood pressure in hypertensive and control subjects and improving baroreflex sensitivity. Continuous noninvasive blood pressure, RR interval, respiration, and end-tidal CO2 (CO 2-et) were monitored in 20 subjects with essential hypertension (56.4±1.9 years) and in 26 controls (52.3±1.4 years) in sitting position during spontaneous breathing and controlled breathing at slower (6/min) and faster (15/min) breathing rate. Baroreflex sensitivity was measured by autoregressive spectral analysis and "alpha angle" method. Slow breathing decreased systolic and diastolic pressures in hypertensive subjects (from 149.7±3.7 to 141.1±4 mm Hg, P2 and faster breathing rate, suggesting hyperventilation and reduced baroreflex sensitivity (P

Original languageEnglish
Pages (from-to)714-718
Number of pages5
JournalHypertension
Volume46
Issue number4
DOIs
Publication statusPublished - Oct 2005

Fingerprint

Baroreflex
Respiration
Blood Pressure
Hyperventilation
Hypertension
Essential Hypertension
Carbon Monoxide
Posture

Keywords

  • Baroreceptors
  • Blood pressure
  • Heart rate
  • Hypertension
  • Nervous system, autonomic
  • Respiration

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Joseph, C. N., Porta, C., Casucci, G., Casiraghi, N., Maffeis, M., Rossi, M., & Bernardi, L. (2005). Slow breathing improves arterial baroreflex sensitivity and decreases blood pressure in essential hypertension. Hypertension, 46(4), 714-718. https://doi.org/10.1161/01.HYP.0000179581.68566.7d

Slow breathing improves arterial baroreflex sensitivity and decreases blood pressure in essential hypertension. / Joseph, Chacko N.; Porta, Cesare; Casucci, Gaia; Casiraghi, Nadia; Maffeis, Mara; Rossi, Marco; Bernardi, Luciano.

In: Hypertension, Vol. 46, No. 4, 10.2005, p. 714-718.

Research output: Contribution to journalArticle

Joseph, CN, Porta, C, Casucci, G, Casiraghi, N, Maffeis, M, Rossi, M & Bernardi, L 2005, 'Slow breathing improves arterial baroreflex sensitivity and decreases blood pressure in essential hypertension', Hypertension, vol. 46, no. 4, pp. 714-718. https://doi.org/10.1161/01.HYP.0000179581.68566.7d
Joseph, Chacko N. ; Porta, Cesare ; Casucci, Gaia ; Casiraghi, Nadia ; Maffeis, Mara ; Rossi, Marco ; Bernardi, Luciano. / Slow breathing improves arterial baroreflex sensitivity and decreases blood pressure in essential hypertension. In: Hypertension. 2005 ; Vol. 46, No. 4. pp. 714-718.
@article{ca4bd9833d984c59a980b00467e79e8e,
title = "Slow breathing improves arterial baroreflex sensitivity and decreases blood pressure in essential hypertension",
abstract = "Sympathetic hyperactivity and parasympathetic withdrawal may cause and sustain hypertension. This autonomic imbalance is in turn related to a reduced or reset arterial baroreflex sensitivity and chemoreflex-induced hyperventilation. Slow breathing at 6 breaths/min increases baroreflex sensitivity and reduces sympathetic activity and chemoreflex activation, suggesting a potentially beneficial effect in hypertension. We tested whether slow breathing was capable of modifying blood pressure in hypertensive and control subjects and improving baroreflex sensitivity. Continuous noninvasive blood pressure, RR interval, respiration, and end-tidal CO2 (CO 2-et) were monitored in 20 subjects with essential hypertension (56.4±1.9 years) and in 26 controls (52.3±1.4 years) in sitting position during spontaneous breathing and controlled breathing at slower (6/min) and faster (15/min) breathing rate. Baroreflex sensitivity was measured by autoregressive spectral analysis and {"}alpha angle{"} method. Slow breathing decreased systolic and diastolic pressures in hypertensive subjects (from 149.7±3.7 to 141.1±4 mm Hg, P2 and faster breathing rate, suggesting hyperventilation and reduced baroreflex sensitivity (P",
keywords = "Baroreceptors, Blood pressure, Heart rate, Hypertension, Nervous system, autonomic, Respiration",
author = "Joseph, {Chacko N.} and Cesare Porta and Gaia Casucci and Nadia Casiraghi and Mara Maffeis and Marco Rossi and Luciano Bernardi",
year = "2005",
month = "10",
doi = "10.1161/01.HYP.0000179581.68566.7d",
language = "English",
volume = "46",
pages = "714--718",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Slow breathing improves arterial baroreflex sensitivity and decreases blood pressure in essential hypertension

AU - Joseph, Chacko N.

AU - Porta, Cesare

AU - Casucci, Gaia

AU - Casiraghi, Nadia

AU - Maffeis, Mara

AU - Rossi, Marco

AU - Bernardi, Luciano

PY - 2005/10

Y1 - 2005/10

N2 - Sympathetic hyperactivity and parasympathetic withdrawal may cause and sustain hypertension. This autonomic imbalance is in turn related to a reduced or reset arterial baroreflex sensitivity and chemoreflex-induced hyperventilation. Slow breathing at 6 breaths/min increases baroreflex sensitivity and reduces sympathetic activity and chemoreflex activation, suggesting a potentially beneficial effect in hypertension. We tested whether slow breathing was capable of modifying blood pressure in hypertensive and control subjects and improving baroreflex sensitivity. Continuous noninvasive blood pressure, RR interval, respiration, and end-tidal CO2 (CO 2-et) were monitored in 20 subjects with essential hypertension (56.4±1.9 years) and in 26 controls (52.3±1.4 years) in sitting position during spontaneous breathing and controlled breathing at slower (6/min) and faster (15/min) breathing rate. Baroreflex sensitivity was measured by autoregressive spectral analysis and "alpha angle" method. Slow breathing decreased systolic and diastolic pressures in hypertensive subjects (from 149.7±3.7 to 141.1±4 mm Hg, P2 and faster breathing rate, suggesting hyperventilation and reduced baroreflex sensitivity (P

AB - Sympathetic hyperactivity and parasympathetic withdrawal may cause and sustain hypertension. This autonomic imbalance is in turn related to a reduced or reset arterial baroreflex sensitivity and chemoreflex-induced hyperventilation. Slow breathing at 6 breaths/min increases baroreflex sensitivity and reduces sympathetic activity and chemoreflex activation, suggesting a potentially beneficial effect in hypertension. We tested whether slow breathing was capable of modifying blood pressure in hypertensive and control subjects and improving baroreflex sensitivity. Continuous noninvasive blood pressure, RR interval, respiration, and end-tidal CO2 (CO 2-et) were monitored in 20 subjects with essential hypertension (56.4±1.9 years) and in 26 controls (52.3±1.4 years) in sitting position during spontaneous breathing and controlled breathing at slower (6/min) and faster (15/min) breathing rate. Baroreflex sensitivity was measured by autoregressive spectral analysis and "alpha angle" method. Slow breathing decreased systolic and diastolic pressures in hypertensive subjects (from 149.7±3.7 to 141.1±4 mm Hg, P2 and faster breathing rate, suggesting hyperventilation and reduced baroreflex sensitivity (P

KW - Baroreceptors

KW - Blood pressure

KW - Heart rate

KW - Hypertension

KW - Nervous system, autonomic

KW - Respiration

UR - http://www.scopus.com/inward/record.url?scp=31944444159&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=31944444159&partnerID=8YFLogxK

U2 - 10.1161/01.HYP.0000179581.68566.7d

DO - 10.1161/01.HYP.0000179581.68566.7d

M3 - Article

C2 - 16129818

AN - SCOPUS:31944444159

VL - 46

SP - 714

EP - 718

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 4

ER -