Twenty-one non-demented Parkinsonian patients and 21 age- and education-matched controls were compared on a neuropsychological test battery and in a forewarned reaction time (RT) task. Slow cortical potentials (SCPs) from frontal, central and parietal sites were measured in the S1-S2 interval of the RT task. The RT task included both non-learning and learning phases. The patients displayed a specific impairment in conditional learning, and in the RT task also failed to make use of conditional (arbitrary) associations to facilitate the initiation of movements. These behavioural deficits were accompanied by reduced amplitude an prolonged latency S1-processing, and by poor timing of the S1-S2 slow negative potential, which also failed to reach optimal pre-imperative levels.
|Number of pages||18|
|Journal||Journal of Psychophysiology|
|Publication status||Published - 1990|
ASJC Scopus subject areas
- Neuropsychology and Physiological Psychology