Abstract
Study Objectives: To analyze non-rapid eye movement (NREM) sleep microstructure of children with dyslexia, by means of cyclic alternating pattern (CAP) analysis and to correlate CAP parameters with neuropsychological measures. Design: Cross-sectional study using polysomnographic recordings and neuropsychological assessments. Setting: Sleep laboratory in academic center. Participants: Sixteen subjects with developmental dyslexia (mean age 10.8 years) and 11 normally reading children (mean age 10.1 years) underwent overnight polysomnographic recording. Intervention: N/A. Measurements and Results: Sleep architecture parameters only showed some statistically significant differences: number of sleep stage shifts per hour of sleep, percentage of N3, and number of R periods were significantly lower in dyslexic children versus controls. CAP analysis revealed a higher total CAP rate and A1 index in stage N3. A2% and A2 index in stage N2 and N3 were lower in dyslexic children while no differences were found for A3 CAP subtypes. The correlation analysis between CAP parameters and cognitive-behavioral measures showed a significant positive correlation between A1 index in N3 with Verbal IQ, full-scale IQ, and Memory and Learning Transfer reading test; while CAP rate in N3 was positively correlated with verbal IQ. Conclusions: To overcome reading difficulties, dyslexic subjects overactivate thalamocortical and hippocampal circuitry to transfer information between cortical posterior and anterior areas. The overactivation of the ancillary frontal areas could account for the CAP rate modifications and mainly for the increase of CAP rate and of A1 index in N3 that seem to be correlated with IQ and reading abilities.
| Original language | English |
|---|---|
| Pages (from-to) | 539-551 |
| Number of pages | 13 |
| Journal | Developmental Neuropsychology |
| Volume | 34 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Sep 2009 |
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ASJC Scopus subject areas
- Developmental and Educational Psychology
- Neuropsychology and Physiological Psychology
Cite this
Slow EEG amplitude oscillations during NREM sleep and reading disabilities in children with dyslexia. / Bruni, Oliviero; Ferri, Raffaele; Novelli, Luana; Finotti, Elena; Terribili, Monica; Troianiello, Miriam; Valente, Donatella; Sabatello, Ugo; Curatolo, Paolo.
In: Developmental Neuropsychology, Vol. 34, No. 5, 09.2009, p. 539-551.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Slow EEG amplitude oscillations during NREM sleep and reading disabilities in children with dyslexia
AU - Bruni, Oliviero
AU - Ferri, Raffaele
AU - Novelli, Luana
AU - Finotti, Elena
AU - Terribili, Monica
AU - Troianiello, Miriam
AU - Valente, Donatella
AU - Sabatello, Ugo
AU - Curatolo, Paolo
PY - 2009/9
Y1 - 2009/9
N2 - Study Objectives: To analyze non-rapid eye movement (NREM) sleep microstructure of children with dyslexia, by means of cyclic alternating pattern (CAP) analysis and to correlate CAP parameters with neuropsychological measures. Design: Cross-sectional study using polysomnographic recordings and neuropsychological assessments. Setting: Sleep laboratory in academic center. Participants: Sixteen subjects with developmental dyslexia (mean age 10.8 years) and 11 normally reading children (mean age 10.1 years) underwent overnight polysomnographic recording. Intervention: N/A. Measurements and Results: Sleep architecture parameters only showed some statistically significant differences: number of sleep stage shifts per hour of sleep, percentage of N3, and number of R periods were significantly lower in dyslexic children versus controls. CAP analysis revealed a higher total CAP rate and A1 index in stage N3. A2% and A2 index in stage N2 and N3 were lower in dyslexic children while no differences were found for A3 CAP subtypes. The correlation analysis between CAP parameters and cognitive-behavioral measures showed a significant positive correlation between A1 index in N3 with Verbal IQ, full-scale IQ, and Memory and Learning Transfer reading test; while CAP rate in N3 was positively correlated with verbal IQ. Conclusions: To overcome reading difficulties, dyslexic subjects overactivate thalamocortical and hippocampal circuitry to transfer information between cortical posterior and anterior areas. The overactivation of the ancillary frontal areas could account for the CAP rate modifications and mainly for the increase of CAP rate and of A1 index in N3 that seem to be correlated with IQ and reading abilities.
AB - Study Objectives: To analyze non-rapid eye movement (NREM) sleep microstructure of children with dyslexia, by means of cyclic alternating pattern (CAP) analysis and to correlate CAP parameters with neuropsychological measures. Design: Cross-sectional study using polysomnographic recordings and neuropsychological assessments. Setting: Sleep laboratory in academic center. Participants: Sixteen subjects with developmental dyslexia (mean age 10.8 years) and 11 normally reading children (mean age 10.1 years) underwent overnight polysomnographic recording. Intervention: N/A. Measurements and Results: Sleep architecture parameters only showed some statistically significant differences: number of sleep stage shifts per hour of sleep, percentage of N3, and number of R periods were significantly lower in dyslexic children versus controls. CAP analysis revealed a higher total CAP rate and A1 index in stage N3. A2% and A2 index in stage N2 and N3 were lower in dyslexic children while no differences were found for A3 CAP subtypes. The correlation analysis between CAP parameters and cognitive-behavioral measures showed a significant positive correlation between A1 index in N3 with Verbal IQ, full-scale IQ, and Memory and Learning Transfer reading test; while CAP rate in N3 was positively correlated with verbal IQ. Conclusions: To overcome reading difficulties, dyslexic subjects overactivate thalamocortical and hippocampal circuitry to transfer information between cortical posterior and anterior areas. The overactivation of the ancillary frontal areas could account for the CAP rate modifications and mainly for the increase of CAP rate and of A1 index in N3 that seem to be correlated with IQ and reading abilities.
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U2 - 10.1080/87565640903133418
DO - 10.1080/87565640903133418
M3 - Article
C2 - 20183717
AN - SCOPUS:75649100121
VL - 34
SP - 539
EP - 551
JO - Developmental Neuropsychology
JF - Developmental Neuropsychology
SN - 8756-5641
IS - 5
ER -