Slow increase in IgG avidity correlates with prevention of human cytomegalovirus transmission to the fetus

Milena Furione, Vanina Rognoni, Antonella Sarasini, Maurizio Zavattoni, Daniele Lilleri, Giuseppe Gerna, Maria Grazia Revello

Research output: Contribution to journalArticlepeer-review

Abstract

Following primary human cytomegalovirus (HCMV) infection, virus-specific IgG antibody shift from low to high avidity with individual variations in the rate of avidity maturation. The kinetics of the avidity maturation of IgG specific for HCMV nuclear antigen in pregnant women with primary infection was investigated. Absorbance values used for avidity index calculation of 286 sequential sera collected from 69 pregnant women with primary HCMV infection were retrieved. Percent difference in absorbance values of IgG antibody bound to the solid phase after urea treatment (IgG avidity) between early (T1, 0-90, median 31 days) and late (T2, 91-180, median 136 days) serum samples was calculated for each woman. Three groups of women were identified: 24/69 (34.8%) women showed high (>100%) avidity increase between T1 and T2 (pattern H), 29/69 (42%) low (

Original languageEnglish
Pages (from-to)1960-1967
Number of pages8
JournalJournal of Medical Virology
Volume85
Issue number11
DOIs
Publication statusPublished - Nov 2013

Keywords

  • Congenital HCMV infection
  • IgG avidity
  • Pregnancy

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Fingerprint

Dive into the research topics of 'Slow increase in IgG avidity correlates with prevention of human cytomegalovirus transmission to the fetus'. Together they form a unique fingerprint.

Cite this