Slowing of information processing in alzheimer disease: Motor as well as cognitive factors

Marialuisa Martelli, Francesco Barban, Pierluigi Zoccolotti, Maria Caterina Silveri

Research output: Contribution to journalArticle

Abstract

OBJECTIVE:: To use Sternberg's Additive Factor Method to determine whether patients with mild Alzheimer disease (AD) are slow in information processing and/or response execution. METHODS:: We gave an odd-even categorization task to 16 patients with probable mild AD and 17 age-matched healthy controls. We recorded reaction and movement times to stimuli varying for noise, target set size, stimulus-response compatibility, and fore-period interval, to probe the cognitive and motor stages of information processing. RESULTS:: Both groups performed the task accurately, indicating good preservation of odd-even categorization in mild AD. The AD group's reaction times were similar to the controls' across conditions, and not selectively affected in any of the cognitive stages of the Additive Factor Method. However, the AD group's movement times were slower than the controls' across conditions. CONCLUSIONS:: AD patients' performance on a task requiring categorization ability was slowed more by motor than cognitive components of information processing. When evaluating the performance of patients with AD in reaction-time paradigms, we should not attribute group differences solely to differences in cognitive processing. Execution components should also be considered.

Original languageEnglish
Pages (from-to)175-185
Number of pages11
JournalCognitive and Behavioral Neurology
Volume25
Issue number4
DOIs
Publication statusPublished - Dec 2012

Fingerprint

Automatic Data Processing
Alzheimer Disease
Reaction Time
Aptitude
Noise

Keywords

  • Alzheimer disease
  • Information processing
  • Noncognitive components
  • Reaction times
  • Sternberg paradigm

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Cognitive Neuroscience

Cite this

Slowing of information processing in alzheimer disease : Motor as well as cognitive factors. / Martelli, Marialuisa; Barban, Francesco; Zoccolotti, Pierluigi; Silveri, Maria Caterina.

In: Cognitive and Behavioral Neurology, Vol. 25, No. 4, 12.2012, p. 175-185.

Research output: Contribution to journalArticle

@article{55935e7af13a49b487ae5798821516d7,
title = "Slowing of information processing in alzheimer disease: Motor as well as cognitive factors",
abstract = "OBJECTIVE:: To use Sternberg's Additive Factor Method to determine whether patients with mild Alzheimer disease (AD) are slow in information processing and/or response execution. METHODS:: We gave an odd-even categorization task to 16 patients with probable mild AD and 17 age-matched healthy controls. We recorded reaction and movement times to stimuli varying for noise, target set size, stimulus-response compatibility, and fore-period interval, to probe the cognitive and motor stages of information processing. RESULTS:: Both groups performed the task accurately, indicating good preservation of odd-even categorization in mild AD. The AD group's reaction times were similar to the controls' across conditions, and not selectively affected in any of the cognitive stages of the Additive Factor Method. However, the AD group's movement times were slower than the controls' across conditions. CONCLUSIONS:: AD patients' performance on a task requiring categorization ability was slowed more by motor than cognitive components of information processing. When evaluating the performance of patients with AD in reaction-time paradigms, we should not attribute group differences solely to differences in cognitive processing. Execution components should also be considered.",
keywords = "Alzheimer disease, Information processing, Noncognitive components, Reaction times, Sternberg paradigm",
author = "Marialuisa Martelli and Francesco Barban and Pierluigi Zoccolotti and Silveri, {Maria Caterina}",
year = "2012",
month = "12",
doi = "10.1097/WNN.0b013e318274fc44",
language = "English",
volume = "25",
pages = "175--185",
journal = "Cognitive and Behavioral Neurology",
issn = "1543-3633",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Slowing of information processing in alzheimer disease

T2 - Motor as well as cognitive factors

AU - Martelli, Marialuisa

AU - Barban, Francesco

AU - Zoccolotti, Pierluigi

AU - Silveri, Maria Caterina

PY - 2012/12

Y1 - 2012/12

N2 - OBJECTIVE:: To use Sternberg's Additive Factor Method to determine whether patients with mild Alzheimer disease (AD) are slow in information processing and/or response execution. METHODS:: We gave an odd-even categorization task to 16 patients with probable mild AD and 17 age-matched healthy controls. We recorded reaction and movement times to stimuli varying for noise, target set size, stimulus-response compatibility, and fore-period interval, to probe the cognitive and motor stages of information processing. RESULTS:: Both groups performed the task accurately, indicating good preservation of odd-even categorization in mild AD. The AD group's reaction times were similar to the controls' across conditions, and not selectively affected in any of the cognitive stages of the Additive Factor Method. However, the AD group's movement times were slower than the controls' across conditions. CONCLUSIONS:: AD patients' performance on a task requiring categorization ability was slowed more by motor than cognitive components of information processing. When evaluating the performance of patients with AD in reaction-time paradigms, we should not attribute group differences solely to differences in cognitive processing. Execution components should also be considered.

AB - OBJECTIVE:: To use Sternberg's Additive Factor Method to determine whether patients with mild Alzheimer disease (AD) are slow in information processing and/or response execution. METHODS:: We gave an odd-even categorization task to 16 patients with probable mild AD and 17 age-matched healthy controls. We recorded reaction and movement times to stimuli varying for noise, target set size, stimulus-response compatibility, and fore-period interval, to probe the cognitive and motor stages of information processing. RESULTS:: Both groups performed the task accurately, indicating good preservation of odd-even categorization in mild AD. The AD group's reaction times were similar to the controls' across conditions, and not selectively affected in any of the cognitive stages of the Additive Factor Method. However, the AD group's movement times were slower than the controls' across conditions. CONCLUSIONS:: AD patients' performance on a task requiring categorization ability was slowed more by motor than cognitive components of information processing. When evaluating the performance of patients with AD in reaction-time paradigms, we should not attribute group differences solely to differences in cognitive processing. Execution components should also be considered.

KW - Alzheimer disease

KW - Information processing

KW - Noncognitive components

KW - Reaction times

KW - Sternberg paradigm

UR - http://www.scopus.com/inward/record.url?scp=84872114181&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872114181&partnerID=8YFLogxK

U2 - 10.1097/WNN.0b013e318274fc44

DO - 10.1097/WNN.0b013e318274fc44

M3 - Article

C2 - 23277138

AN - SCOPUS:84872114181

VL - 25

SP - 175

EP - 185

JO - Cognitive and Behavioral Neurology

JF - Cognitive and Behavioral Neurology

SN - 1543-3633

IS - 4

ER -