Ruolo della RM a doppio contrasto rispetto alla TC multidetettore nella diagnosi del piccolo epatocarcinoma (≤3 cm) su cirrosi

Translated title of the contribution: Small (≤3 cm) hepatocellular carcinoma in cirrhosis: The role of double contrast agents in MR imaging vs. multidetector-row CT

R. Golfieri, E. Marini, A. Bazzocchi, F. Fusco, F. Trevisani, C. Sama, G. Mazzella, S. Cavuto, F. Piscaglia, L. Bolondi

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose. We prospectively compared gadoliniumenhanced magnetic resonance imaging (dynamic MRI), superparamagnetic iron oxide (SPIO) (ferucarbotran) MRI and multidetector-row computed tomography (MDCT) and the combination of dynamic MRI plus MDCT vs. dynamic MRI plus SPIO-MRI (double-contrast MRI: DC-MRI) for the detection of small (=3 cm) hepatocellular carcinomas (HCCs). Materials and Methods. Sixty-three patients with liver cirrhosis and suspicious nodules detected during ultrasound (US) surveillance underwent DC-MRI in the same imaging session and MDCT within 15 days. The final diagnosis was established at pathology on the explanted liver (n=10), resection (n=6) and biopsy (n=38) specimens or at 2-years' follow-up (n=9). Results. One hundred and twenty-three nodules were detected: 87 were confirmed HCCs in 54 patients. The accuracy of SPIO-MRI and dynamic MRI were similar, both being superior to MDCT. Dynamic MRI demonstrated the highest sensitivity (83.9%; p1 cm and the highest specificity (83.3%) superior to dynamic MRI (p1 cm. Furthermore its per-patient negative predictive value was the highest (100%), and significantly higher than all the other methods. Conclusions. DC-MRI is the most sensitive and accurate method and can be confidently used as a single-step procedure for the detection of small HCCs, with the exception of lesions

Translated title of the contributionSmall (≤3 cm) hepatocellular carcinoma in cirrhosis: The role of double contrast agents in MR imaging vs. multidetector-row CT
Original languageItalian
Pages (from-to)1239-1266
Number of pages28
JournalRadiologia Medica
Volume114
Issue number8
DOIs
Publication statusPublished - Dec 2009

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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