Ruolo della RM a doppio contrasto rispetto alla TC multidetettore nella diagnosi del piccolo epatocarcinoma (≤3 cm) su cirrosi

Translated title of the contribution: Small (≤3 cm) hepatocellular carcinoma in cirrhosis: The role of double contrast agents in MR imaging vs. multidetector-row CT

R. Golfieri, E. Marini, A. Bazzocchi, F. Fusco, F. Trevisani, C. Sama, G. Mazzella, S. Cavuto, F. Piscaglia, L. Bolondi

Research output: Contribution to journalArticle

Abstract

Purpose. We prospectively compared gadoliniumenhanced magnetic resonance imaging (dynamic MRI), superparamagnetic iron oxide (SPIO) (ferucarbotran) MRI and multidetector-row computed tomography (MDCT) and the combination of dynamic MRI plus MDCT vs. dynamic MRI plus SPIO-MRI (double-contrast MRI: DC-MRI) for the detection of small (=3 cm) hepatocellular carcinomas (HCCs). Materials and Methods. Sixty-three patients with liver cirrhosis and suspicious nodules detected during ultrasound (US) surveillance underwent DC-MRI in the same imaging session and MDCT within 15 days. The final diagnosis was established at pathology on the explanted liver (n=10), resection (n=6) and biopsy (n=38) specimens or at 2-years' follow-up (n=9). Results. One hundred and twenty-three nodules were detected: 87 were confirmed HCCs in 54 patients. The accuracy of SPIO-MRI and dynamic MRI were similar, both being superior to MDCT. Dynamic MRI demonstrated the highest sensitivity (83.9%; p1 cm and the highest specificity (83.3%) superior to dynamic MRI (p1 cm. Furthermore its per-patient negative predictive value was the highest (100%), and significantly higher than all the other methods. Conclusions. DC-MRI is the most sensitive and accurate method and can be confidently used as a single-step procedure for the detection of small HCCs, with the exception of lesions

Original languageItalian
Pages (from-to)1239-1266
Number of pages28
JournalRadiologia Medica
Volume114
Issue number8
DOIs
Publication statusPublished - Dec 2009

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Multidetector Computed Tomography
Contrast Media
Hepatocellular Carcinoma
Fibrosis
Liver Cirrhosis
Magnetic Resonance Imaging
Pathology
Biopsy
Liver
ferric oxide

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Golfieri, R., Marini, E., Bazzocchi, A., Fusco, F., Trevisani, F., Sama, C., ... Bolondi, L. (2009). Ruolo della RM a doppio contrasto rispetto alla TC multidetettore nella diagnosi del piccolo epatocarcinoma (≤3 cm) su cirrosi. Radiologia Medica, 114(8), 1239-1266. https://doi.org/10.1007/s11547-009-0439-x

Ruolo della RM a doppio contrasto rispetto alla TC multidetettore nella diagnosi del piccolo epatocarcinoma (≤3 cm) su cirrosi. / Golfieri, R.; Marini, E.; Bazzocchi, A.; Fusco, F.; Trevisani, F.; Sama, C.; Mazzella, G.; Cavuto, S.; Piscaglia, F.; Bolondi, L.

In: Radiologia Medica, Vol. 114, No. 8, 12.2009, p. 1239-1266.

Research output: Contribution to journalArticle

Golfieri, R, Marini, E, Bazzocchi, A, Fusco, F, Trevisani, F, Sama, C, Mazzella, G, Cavuto, S, Piscaglia, F & Bolondi, L 2009, 'Ruolo della RM a doppio contrasto rispetto alla TC multidetettore nella diagnosi del piccolo epatocarcinoma (≤3 cm) su cirrosi', Radiologia Medica, vol. 114, no. 8, pp. 1239-1266. https://doi.org/10.1007/s11547-009-0439-x
Golfieri, R. ; Marini, E. ; Bazzocchi, A. ; Fusco, F. ; Trevisani, F. ; Sama, C. ; Mazzella, G. ; Cavuto, S. ; Piscaglia, F. ; Bolondi, L. / Ruolo della RM a doppio contrasto rispetto alla TC multidetettore nella diagnosi del piccolo epatocarcinoma (≤3 cm) su cirrosi. In: Radiologia Medica. 2009 ; Vol. 114, No. 8. pp. 1239-1266.
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abstract = "Purpose. We prospectively compared gadoliniumenhanced magnetic resonance imaging (dynamic MRI), superparamagnetic iron oxide (SPIO) (ferucarbotran) MRI and multidetector-row computed tomography (MDCT) and the combination of dynamic MRI plus MDCT vs. dynamic MRI plus SPIO-MRI (double-contrast MRI: DC-MRI) for the detection of small (=3 cm) hepatocellular carcinomas (HCCs). Materials and Methods. Sixty-three patients with liver cirrhosis and suspicious nodules detected during ultrasound (US) surveillance underwent DC-MRI in the same imaging session and MDCT within 15 days. The final diagnosis was established at pathology on the explanted liver (n=10), resection (n=6) and biopsy (n=38) specimens or at 2-years' follow-up (n=9). Results. One hundred and twenty-three nodules were detected: 87 were confirmed HCCs in 54 patients. The accuracy of SPIO-MRI and dynamic MRI were similar, both being superior to MDCT. Dynamic MRI demonstrated the highest sensitivity (83.9{\%}; p1 cm and the highest specificity (83.3{\%}) superior to dynamic MRI (p1 cm. Furthermore its per-patient negative predictive value was the highest (100{\%}), and significantly higher than all the other methods. Conclusions. DC-MRI is the most sensitive and accurate method and can be confidently used as a single-step procedure for the detection of small HCCs, with the exception of lesions",
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AU - Golfieri, R.

AU - Marini, E.

AU - Bazzocchi, A.

AU - Fusco, F.

AU - Trevisani, F.

AU - Sama, C.

AU - Mazzella, G.

AU - Cavuto, S.

AU - Piscaglia, F.

AU - Bolondi, L.

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N2 - Purpose. We prospectively compared gadoliniumenhanced magnetic resonance imaging (dynamic MRI), superparamagnetic iron oxide (SPIO) (ferucarbotran) MRI and multidetector-row computed tomography (MDCT) and the combination of dynamic MRI plus MDCT vs. dynamic MRI plus SPIO-MRI (double-contrast MRI: DC-MRI) for the detection of small (=3 cm) hepatocellular carcinomas (HCCs). Materials and Methods. Sixty-three patients with liver cirrhosis and suspicious nodules detected during ultrasound (US) surveillance underwent DC-MRI in the same imaging session and MDCT within 15 days. The final diagnosis was established at pathology on the explanted liver (n=10), resection (n=6) and biopsy (n=38) specimens or at 2-years' follow-up (n=9). Results. One hundred and twenty-three nodules were detected: 87 were confirmed HCCs in 54 patients. The accuracy of SPIO-MRI and dynamic MRI were similar, both being superior to MDCT. Dynamic MRI demonstrated the highest sensitivity (83.9%; p1 cm and the highest specificity (83.3%) superior to dynamic MRI (p1 cm. Furthermore its per-patient negative predictive value was the highest (100%), and significantly higher than all the other methods. Conclusions. DC-MRI is the most sensitive and accurate method and can be confidently used as a single-step procedure for the detection of small HCCs, with the exception of lesions

AB - Purpose. We prospectively compared gadoliniumenhanced magnetic resonance imaging (dynamic MRI), superparamagnetic iron oxide (SPIO) (ferucarbotran) MRI and multidetector-row computed tomography (MDCT) and the combination of dynamic MRI plus MDCT vs. dynamic MRI plus SPIO-MRI (double-contrast MRI: DC-MRI) for the detection of small (=3 cm) hepatocellular carcinomas (HCCs). Materials and Methods. Sixty-three patients with liver cirrhosis and suspicious nodules detected during ultrasound (US) surveillance underwent DC-MRI in the same imaging session and MDCT within 15 days. The final diagnosis was established at pathology on the explanted liver (n=10), resection (n=6) and biopsy (n=38) specimens or at 2-years' follow-up (n=9). Results. One hundred and twenty-three nodules were detected: 87 were confirmed HCCs in 54 patients. The accuracy of SPIO-MRI and dynamic MRI were similar, both being superior to MDCT. Dynamic MRI demonstrated the highest sensitivity (83.9%; p1 cm and the highest specificity (83.3%) superior to dynamic MRI (p1 cm. Furthermore its per-patient negative predictive value was the highest (100%), and significantly higher than all the other methods. Conclusions. DC-MRI is the most sensitive and accurate method and can be confidently used as a single-step procedure for the detection of small HCCs, with the exception of lesions

KW - Cirrhosis

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KW - Multiphasic helical multidetector row CT (MDCT)

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KW - SPIO-enhanced MRI

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