Abstract
Purpose. We prospectively compared gadoliniumenhanced magnetic resonance imaging (dynamic MRI), superparamagnetic iron oxide (SPIO) (ferucarbotran) MRI and multidetector-row computed tomography (MDCT) and the combination of dynamic MRI plus MDCT vs. dynamic MRI plus SPIO-MRI (double-contrast MRI: DC-MRI) for the detection of small (=3 cm) hepatocellular carcinomas (HCCs). Materials and Methods. Sixty-three patients with liver cirrhosis and suspicious nodules detected during ultrasound (US) surveillance underwent DC-MRI in the same imaging session and MDCT within 15 days. The final diagnosis was established at pathology on the explanted liver (n=10), resection (n=6) and biopsy (n=38) specimens or at 2-years' follow-up (n=9). Results. One hundred and twenty-three nodules were detected: 87 were confirmed HCCs in 54 patients. The accuracy of SPIO-MRI and dynamic MRI were similar, both being superior to MDCT. Dynamic MRI demonstrated the highest sensitivity (83.9%; p1 cm and the highest specificity (83.3%) superior to dynamic MRI (p1 cm. Furthermore its per-patient negative predictive value was the highest (100%), and significantly higher than all the other methods. Conclusions. DC-MRI is the most sensitive and accurate method and can be confidently used as a single-step procedure for the detection of small HCCs, with the exception of lesions
| Original language | Italian |
|---|---|
| Pages (from-to) | 1239-1266 |
| Number of pages | 28 |
| Journal | Radiologia Medica |
| Volume | 114 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Dec 2009 |
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ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Medicine(all)
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Ruolo della RM a doppio contrasto rispetto alla TC multidetettore nella diagnosi del piccolo epatocarcinoma (≤3 cm) su cirrosi. / Golfieri, R.; Marini, E.; Bazzocchi, A.; Fusco, F.; Trevisani, F.; Sama, C.; Mazzella, G.; Cavuto, S.; Piscaglia, F.; Bolondi, L.
In: Radiologia Medica, Vol. 114, No. 8, 12.2009, p. 1239-1266.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ruolo della RM a doppio contrasto rispetto alla TC multidetettore nella diagnosi del piccolo epatocarcinoma (≤3 cm) su cirrosi
AU - Golfieri, R.
AU - Marini, E.
AU - Bazzocchi, A.
AU - Fusco, F.
AU - Trevisani, F.
AU - Sama, C.
AU - Mazzella, G.
AU - Cavuto, S.
AU - Piscaglia, F.
AU - Bolondi, L.
PY - 2009/12
Y1 - 2009/12
N2 - Purpose. We prospectively compared gadoliniumenhanced magnetic resonance imaging (dynamic MRI), superparamagnetic iron oxide (SPIO) (ferucarbotran) MRI and multidetector-row computed tomography (MDCT) and the combination of dynamic MRI plus MDCT vs. dynamic MRI plus SPIO-MRI (double-contrast MRI: DC-MRI) for the detection of small (=3 cm) hepatocellular carcinomas (HCCs). Materials and Methods. Sixty-three patients with liver cirrhosis and suspicious nodules detected during ultrasound (US) surveillance underwent DC-MRI in the same imaging session and MDCT within 15 days. The final diagnosis was established at pathology on the explanted liver (n=10), resection (n=6) and biopsy (n=38) specimens or at 2-years' follow-up (n=9). Results. One hundred and twenty-three nodules were detected: 87 were confirmed HCCs in 54 patients. The accuracy of SPIO-MRI and dynamic MRI were similar, both being superior to MDCT. Dynamic MRI demonstrated the highest sensitivity (83.9%; p1 cm and the highest specificity (83.3%) superior to dynamic MRI (p1 cm. Furthermore its per-patient negative predictive value was the highest (100%), and significantly higher than all the other methods. Conclusions. DC-MRI is the most sensitive and accurate method and can be confidently used as a single-step procedure for the detection of small HCCs, with the exception of lesions
AB - Purpose. We prospectively compared gadoliniumenhanced magnetic resonance imaging (dynamic MRI), superparamagnetic iron oxide (SPIO) (ferucarbotran) MRI and multidetector-row computed tomography (MDCT) and the combination of dynamic MRI plus MDCT vs. dynamic MRI plus SPIO-MRI (double-contrast MRI: DC-MRI) for the detection of small (=3 cm) hepatocellular carcinomas (HCCs). Materials and Methods. Sixty-three patients with liver cirrhosis and suspicious nodules detected during ultrasound (US) surveillance underwent DC-MRI in the same imaging session and MDCT within 15 days. The final diagnosis was established at pathology on the explanted liver (n=10), resection (n=6) and biopsy (n=38) specimens or at 2-years' follow-up (n=9). Results. One hundred and twenty-three nodules were detected: 87 were confirmed HCCs in 54 patients. The accuracy of SPIO-MRI and dynamic MRI were similar, both being superior to MDCT. Dynamic MRI demonstrated the highest sensitivity (83.9%; p1 cm and the highest specificity (83.3%) superior to dynamic MRI (p1 cm. Furthermore its per-patient negative predictive value was the highest (100%), and significantly higher than all the other methods. Conclusions. DC-MRI is the most sensitive and accurate method and can be confidently used as a single-step procedure for the detection of small HCCs, with the exception of lesions
KW - Cirrhosis
KW - Contrast agents
KW - Gd-DTPA-enhanced MRI
KW - Hepatocellular carcinoma
KW - Liver
KW - Multiphasic helical multidetector row CT (MDCT)
KW - Neoplasms
KW - SPIO-enhanced MRI
UR - http://www.scopus.com/inward/record.url?scp=75949118403&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=75949118403&partnerID=8YFLogxK
U2 - 10.1007/s11547-009-0439-x
DO - 10.1007/s11547-009-0439-x
M3 - Articolo
C2 - 19697104
AN - SCOPUS:75949118403
VL - 114
SP - 1239
EP - 1266
JO - Radiologia Medica
JF - Radiologia Medica
SN - 0033-8362
IS - 8
ER -