Small acoustic neuromas: Monitoring the growth rate by MRI

Giovanni Carlo Modugno, A. Pirodda, G. G. Ferri, A. Fioravanti, F. Calbucci, A. Pezzi, A. R. Ceroni, E. Pirodda

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

In a proportion of small acoustic neuroma patients, monitoring with magnetic resonance imaging shows no volumetric increase of tumour size over the years. The object of the study was to identify some indications for the clinical choice between immediate surgery (with the related risks) and watchful waiting. We performed a retrospective study of 47 non-surgically-treated patients affected by acoustic neuroma and monitored by gadolinium-enhanced MRI between January 1990 and February 1999. Six clinical variables (tumour size, sex, age, initial symptoms, ABR pattern and duration of the symptoms) were examined by univariate analysis. Chi-square test and variance analysis were performed to evaluate the statistical significance. In 30/47 (63.8%) cases, no growth was observed during the entire period of follow-up. In the remaining 17/47 (36.2%) patients, a volumetric increase was detected, most often within the first year of observation. The clinical factors examined did not significantly correlate with growth. Despite the relatively short period of observation, we believe that immediate surgery does not need to be considered mandatory for small acoustic neuromas, even in young patients. However the irregular behaviour of the tumour underlines the importance of monitoring with MRI at least once a year.

Original languageEnglish
Pages (from-to)1063-1067
Number of pages5
JournalActa Neurochirurgica
Volume141
Issue number10
DOIs
Publication statusPublished - 1999

Fingerprint

Acoustic Neuroma
Growth
Observation
Watchful Waiting
Neoplasms
Gadolinium
Physiologic Monitoring
Chi-Square Distribution
Analysis of Variance
Retrospective Studies
Magnetic Resonance Imaging

Keywords

  • Acoustic neuroma
  • Growth rate
  • MRI
  • Predictive factors

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Modugno, G. C., Pirodda, A., Ferri, G. G., Fioravanti, A., Calbucci, F., Pezzi, A., ... Pirodda, E. (1999). Small acoustic neuromas: Monitoring the growth rate by MRI. Acta Neurochirurgica, 141(10), 1063-1067. https://doi.org/10.1007/s007010050483

Small acoustic neuromas : Monitoring the growth rate by MRI. / Modugno, Giovanni Carlo; Pirodda, A.; Ferri, G. G.; Fioravanti, A.; Calbucci, F.; Pezzi, A.; Ceroni, A. R.; Pirodda, E.

In: Acta Neurochirurgica, Vol. 141, No. 10, 1999, p. 1063-1067.

Research output: Contribution to journalArticle

Modugno, GC, Pirodda, A, Ferri, GG, Fioravanti, A, Calbucci, F, Pezzi, A, Ceroni, AR & Pirodda, E 1999, 'Small acoustic neuromas: Monitoring the growth rate by MRI', Acta Neurochirurgica, vol. 141, no. 10, pp. 1063-1067. https://doi.org/10.1007/s007010050483
Modugno GC, Pirodda A, Ferri GG, Fioravanti A, Calbucci F, Pezzi A et al. Small acoustic neuromas: Monitoring the growth rate by MRI. Acta Neurochirurgica. 1999;141(10):1063-1067. https://doi.org/10.1007/s007010050483
Modugno, Giovanni Carlo ; Pirodda, A. ; Ferri, G. G. ; Fioravanti, A. ; Calbucci, F. ; Pezzi, A. ; Ceroni, A. R. ; Pirodda, E. / Small acoustic neuromas : Monitoring the growth rate by MRI. In: Acta Neurochirurgica. 1999 ; Vol. 141, No. 10. pp. 1063-1067.
@article{e9d74a3c212644d599360596263a9815,
title = "Small acoustic neuromas: Monitoring the growth rate by MRI",
abstract = "In a proportion of small acoustic neuroma patients, monitoring with magnetic resonance imaging shows no volumetric increase of tumour size over the years. The object of the study was to identify some indications for the clinical choice between immediate surgery (with the related risks) and watchful waiting. We performed a retrospective study of 47 non-surgically-treated patients affected by acoustic neuroma and monitored by gadolinium-enhanced MRI between January 1990 and February 1999. Six clinical variables (tumour size, sex, age, initial symptoms, ABR pattern and duration of the symptoms) were examined by univariate analysis. Chi-square test and variance analysis were performed to evaluate the statistical significance. In 30/47 (63.8{\%}) cases, no growth was observed during the entire period of follow-up. In the remaining 17/47 (36.2{\%}) patients, a volumetric increase was detected, most often within the first year of observation. The clinical factors examined did not significantly correlate with growth. Despite the relatively short period of observation, we believe that immediate surgery does not need to be considered mandatory for small acoustic neuromas, even in young patients. However the irregular behaviour of the tumour underlines the importance of monitoring with MRI at least once a year.",
keywords = "Acoustic neuroma, Growth rate, MRI, Predictive factors",
author = "Modugno, {Giovanni Carlo} and A. Pirodda and Ferri, {G. G.} and A. Fioravanti and F. Calbucci and A. Pezzi and Ceroni, {A. R.} and E. Pirodda",
year = "1999",
doi = "10.1007/s007010050483",
language = "English",
volume = "141",
pages = "1063--1067",
journal = "Acta Neurochirurgica",
issn = "0001-6268",
publisher = "Springer Wien",
number = "10",

}

TY - JOUR

T1 - Small acoustic neuromas

T2 - Monitoring the growth rate by MRI

AU - Modugno, Giovanni Carlo

AU - Pirodda, A.

AU - Ferri, G. G.

AU - Fioravanti, A.

AU - Calbucci, F.

AU - Pezzi, A.

AU - Ceroni, A. R.

AU - Pirodda, E.

PY - 1999

Y1 - 1999

N2 - In a proportion of small acoustic neuroma patients, monitoring with magnetic resonance imaging shows no volumetric increase of tumour size over the years. The object of the study was to identify some indications for the clinical choice between immediate surgery (with the related risks) and watchful waiting. We performed a retrospective study of 47 non-surgically-treated patients affected by acoustic neuroma and monitored by gadolinium-enhanced MRI between January 1990 and February 1999. Six clinical variables (tumour size, sex, age, initial symptoms, ABR pattern and duration of the symptoms) were examined by univariate analysis. Chi-square test and variance analysis were performed to evaluate the statistical significance. In 30/47 (63.8%) cases, no growth was observed during the entire period of follow-up. In the remaining 17/47 (36.2%) patients, a volumetric increase was detected, most often within the first year of observation. The clinical factors examined did not significantly correlate with growth. Despite the relatively short period of observation, we believe that immediate surgery does not need to be considered mandatory for small acoustic neuromas, even in young patients. However the irregular behaviour of the tumour underlines the importance of monitoring with MRI at least once a year.

AB - In a proportion of small acoustic neuroma patients, monitoring with magnetic resonance imaging shows no volumetric increase of tumour size over the years. The object of the study was to identify some indications for the clinical choice between immediate surgery (with the related risks) and watchful waiting. We performed a retrospective study of 47 non-surgically-treated patients affected by acoustic neuroma and monitored by gadolinium-enhanced MRI between January 1990 and February 1999. Six clinical variables (tumour size, sex, age, initial symptoms, ABR pattern and duration of the symptoms) were examined by univariate analysis. Chi-square test and variance analysis were performed to evaluate the statistical significance. In 30/47 (63.8%) cases, no growth was observed during the entire period of follow-up. In the remaining 17/47 (36.2%) patients, a volumetric increase was detected, most often within the first year of observation. The clinical factors examined did not significantly correlate with growth. Despite the relatively short period of observation, we believe that immediate surgery does not need to be considered mandatory for small acoustic neuromas, even in young patients. However the irregular behaviour of the tumour underlines the importance of monitoring with MRI at least once a year.

KW - Acoustic neuroma

KW - Growth rate

KW - MRI

KW - Predictive factors

UR - http://www.scopus.com/inward/record.url?scp=0032698452&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032698452&partnerID=8YFLogxK

U2 - 10.1007/s007010050483

DO - 10.1007/s007010050483

M3 - Article

C2 - 10550650

AN - SCOPUS:0032698452

VL - 141

SP - 1063

EP - 1067

JO - Acta Neurochirurgica

JF - Acta Neurochirurgica

SN - 0001-6268

IS - 10

ER -