Abstract
This study investigated the relationships between pathological changes in small airways (1/FVC) <70%] in 12 subjects and normal lung function in 10. When all subjects were considered together, total airway wall thickness was significantly correlated with FEV1/FVC (r2 = 0.25), reactivity to methacholine (r2 = 0.26), and slope of linear regression of FVC against FEV1 values recorded during the methacholine challenge (r2 = 0.56). Loss of peribronchiolar alveolar attachments was significantly associated (r2 = 0.25) with a bronchoconstrictor effect of deep inhalation, as assessed from a maximal-to-partial expiratory flow ratio
Original language | English |
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Pages (from-to) | 441-447 |
Number of pages | 7 |
Journal | Journal of Applied Physiology |
Volume | 95 |
Issue number | 1 |
Publication status | Published - Jul 1 2003 |
Keywords
- Airway closure
- Airway hyperresponsiveness
- Deep inhalation
- Interdependence
- Smoking
ASJC Scopus subject areas
- Physiology
- Endocrinology
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation