Small airway morphology and lung function in the transition from normality to chronic airway obstruction

Angelo Corsico; Manlio Milanese; Simonetta Baraldo; Gian Luca Casoni; Alberto Papi; Anna Maria Riccio; Isa Cerveri; Marina Saetta; Vito Brusasco

Small airway morphology and lung function in the transition from normality to chronic airway obstruction

Angelo Corsico, Manlio Milanese, Simonetta Baraldo, Gian Luca Casoni, Alberto Papi, Anna Maria Riccio, Isa Cerveri, Marina Saetta, Vito Brusasco

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

This study investigated the relationships between pathological changes in small airways (1/FVC) <70%] in 12 subjects and normal lung function in 10. When all subjects were considered together, total airway wall thickness was significantly correlated with FEV₁/FVC (r² = 0.25), reactivity to methacholine (r² = 0.26), and slope of linear regression of FVC against FEV₁ values recorded during the methacholine challenge (r² = 0.56). Loss of peribronchiolar alveolar attachments was significantly associated (r² = 0.25) with a bronchoconstrictor effect of deep inhalation, as assessed from a maximal-to-partial expiratory flow ratio

Original language	English
Pages (from-to)	441-447
Number of pages	7
Journal	Journal of Applied Physiology
Volume	95
Issue number	1
Publication status	Published - Jul 1 2003

Keywords

Airway closure
Airway hyperresponsiveness
Deep inhalation
Interdependence
Smoking

ASJC Scopus subject areas

Physiology
Endocrinology
Orthopedics and Sports Medicine
Physical Therapy, Sports Therapy and Rehabilitation

Cite this

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abstract = "This study investigated the relationships between pathological changes in small airways (1/FVC) <70%] in 12 subjects and normal lung function in 10. When all subjects were considered together, total airway wall thickness was significantly correlated with FEV1/FVC (r2 = 0.25), reactivity to methacholine (r2 = 0.26), and slope of linear regression of FVC against FEV1 values recorded during the methacholine challenge (r2 = 0.56). Loss of peribronchiolar alveolar attachments was significantly associated (r2 = 0.25) with a bronchoconstrictor effect of deep inhalation, as assessed from a maximal-to-partial expiratory flow ratio ",

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AU - Corsico, Angelo

AU - Milanese, Manlio

AU - Baraldo, Simonetta

AU - Casoni, Gian Luca

AU - Papi, Alberto

AU - Riccio, Anna Maria

AU - Cerveri, Isa

AU - Saetta, Marina

AU - Brusasco, Vito

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N2 - This study investigated the relationships between pathological changes in small airways (1/FVC) <70%] in 12 subjects and normal lung function in 10. When all subjects were considered together, total airway wall thickness was significantly correlated with FEV1/FVC (r2 = 0.25), reactivity to methacholine (r2 = 0.26), and slope of linear regression of FVC against FEV1 values recorded during the methacholine challenge (r2 = 0.56). Loss of peribronchiolar alveolar attachments was significantly associated (r2 = 0.25) with a bronchoconstrictor effect of deep inhalation, as assessed from a maximal-to-partial expiratory flow ratio

AB - This study investigated the relationships between pathological changes in small airways (1/FVC) <70%] in 12 subjects and normal lung function in 10. When all subjects were considered together, total airway wall thickness was significantly correlated with FEV1/FVC (r2 = 0.25), reactivity to methacholine (r2 = 0.26), and slope of linear regression of FVC against FEV1 values recorded during the methacholine challenge (r2 = 0.56). Loss of peribronchiolar alveolar attachments was significantly associated (r2 = 0.25) with a bronchoconstrictor effect of deep inhalation, as assessed from a maximal-to-partial expiratory flow ratio

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KW - Airway hyperresponsiveness

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KW - Interdependence

KW - Smoking

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Small airway morphology and lung function in the transition from normality to chronic airway obstruction

Abstract

Keywords

ASJC Scopus subject areas

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