Small airway morphology and lung function in the transition from normality to chronic airway obstruction

Angelo Corsico, Manlio Milanese, Simonetta Baraldo, Gian Luca Casoni, Alberto Papi, Anna Maria Riccio, Isa Cerveri, Marina Saetta, Vito Brusasco

Research output: Contribution to journalArticle

Abstract

This study investigated the relationships between pathological changes in small airways (1/FVC) <70%] in 12 subjects and normal lung function in 10. When all subjects were considered together, total airway wall thickness was significantly correlated with FEV1/FVC (r2 = 0.25), reactivity to methacholine (r2 = 0.26), and slope of linear regression of FVC against FEV1 values recorded during the methacholine challenge (r2 = 0.56). Loss of peribronchiolar alveolar attachments was significantly associated (r2 = 0.25) with a bronchoconstrictor effect of deep inhalation, as assessed from a maximal-to-partial expiratory flow ratio

Original languageEnglish
Pages (from-to)441-447
Number of pages7
JournalJournal of Applied Physiology
Volume95
Issue number1
Publication statusPublished - Jul 1 2003

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Keywords

  • Airway closure
  • Airway hyperresponsiveness
  • Deep inhalation
  • Interdependence
  • Smoking

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Corsico, A., Milanese, M., Baraldo, S., Casoni, G. L., Papi, A., Riccio, A. M., Cerveri, I., Saetta, M., & Brusasco, V. (2003). Small airway morphology and lung function in the transition from normality to chronic airway obstruction. Journal of Applied Physiology, 95(1), 441-447.