Small bowel capsule endoscopy in clinical practice: A multicenter 7-year survey

Emanuele Rondonotti, Marco Soncini, Carlo Girelli, Giovanni Ballardini, Guglielmo Bianchi, Sergio Brunati, Laura Centenara, Pietro Cesari, Claudio Cortelezzi, Simona Curioni, Claudio Gozzini, Renzo Gullotta, Marco Lazzaroni, Marta Maino, Giovanna Mandelli, Nicola Mantovani, Elisabetta Morandi, Carlo Pansoni, Walter Piubello, Rocco PutignanoRenzo Schalling, Maria Tatarella, Federica Villa, Pasquale Vitagliano, Antonio Russo, Dario Conte, Enzo Masci, Roberto De Franchis

Research output: Contribution to journalArticle


Background and aim: Data about small bowel capsule endoscopy (SBCE) come from studies involving small and highly selected populations. The study aim was to describe extent of use, indications, results, complications, and practical issues of SBCE in clinical practice in a Northern Italian Region (Lombardia). Materials and methods: Twenty-three out of 29 invited centers fulfilled a specific questionnaire. Results: Between 2001 and 2008, 2921 procedures were performed and both the number of centers performing SBCE (from 5 to 29) and the number of SBCE (from 7.2 to 69.2 per month) increased steadily. The main indications for SBCE were: obscure gastrointestinal bleeding (OGIB) (43.4%), unexplained anemia (23.9%), suspected Crohn's disease (7.8%) and abdominal pain (5.3%). Overall, SBCE was positive in 50% of cases, negative in 36% and undefined in 14%. The highest diagnostic yields were observed in patients with OGIB (62.5%), polypoid syndromes (74.1%), known (54.8%) or suspected (47.3%) inflammatory bowel disease, while the yields were low in patients examined for chronic diarrhea (27.4%) and abdominal pain (14.9%), 61 patients (2.1%) experienced capsule retention. Thirty-two of them eventually excreted the capsule naturally while endoscopic or surgical retrieval was necessary in 29 (1%) (in two because of obstruction). Conclusion: Over a period of 7 years the use of SBCE in Lombardia increased steadily confirming, in clinical practice, a high diagnostic yield and an acceptable safety profile.

Original languageEnglish
Pages (from-to)1380-1386
Number of pages7
JournalEuropean Journal of Gastroenterology and Hepatology
Issue number11
Publication statusPublished - Nov 2010


  • capsule endoscopy
  • cost estimation
  • obscure gastrointestinal bleeding

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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    Rondonotti, E., Soncini, M., Girelli, C., Ballardini, G., Bianchi, G., Brunati, S., Centenara, L., Cesari, P., Cortelezzi, C., Curioni, S., Gozzini, C., Gullotta, R., Lazzaroni, M., Maino, M., Mandelli, G., Mantovani, N., Morandi, E., Pansoni, C., Piubello, W., ... De Franchis, R. (2010). Small bowel capsule endoscopy in clinical practice: A multicenter 7-year survey. European Journal of Gastroenterology and Hepatology, 22(11), 1380-1386.