Small bowel carcinomas associated with immune-mediated intestinal disorders: The current knowledge

Paolo Giuffrida, Alessandro Vanoli, Giovanni Arpa, Arturo Bonometti, Ombretta Luinetti, Enrico Solcia, Gino Roberto Corazza, Marco Paulli, Antonio Di Sabatino

Research output: Contribution to journalReview articlepeer-review


Small bowel carcinomas (SBC) are uncommon neoplasms, whose predisposing conditions include hereditary syndromes and immune-mediated intestinal disorders including coeliac disease (CD) and Crohn’s disease (CrD). Although both CD-associated SBC (CD-SBC) and CrD-associated SBC (CrD-SBC) arise from an inflammatory background, they differ substantially in tumour cell phenotype, frequency of microsatellite instability and nuclear β-catenin expression, as well as in prognosis. For these patients, high tumour-infiltrating lymphocyte density and glandular/medullary histotype represent independent positive prognostic factors. Dysplasia adjacent to SBC is rare and characterized by intestinal phenotype and nuclear β-catenin in CD, while it is frequent and typified by gastro-pancreatobiliary marker expression and preserved membranous β-catenin in CrD. Recent evidence suggests that Epstein-Barr virus-positive dysplasia and SBC, albeit exceptional, do exist and are associated with CrD. In this review, we summarize the novel pathological and molecular insights of clinical and therapeutic interest to guide the care of CD-SBC and CrD-SBC.

Original languageEnglish
Article number31
Issue number1
Publication statusPublished - Jan 1 2019


  • Coeliac disease
  • Crohn’s disease
  • Dysplasia
  • Histotype
  • Overall survival
  • Tumour-infiltrating lymphocyte

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Small bowel carcinomas associated with immune-mediated intestinal disorders: The current knowledge'. Together they form a unique fingerprint.

Cite this