Small-bowel neoplasms in patients undergoing video capsule endoscopy: A multicenter European study

Emanuele Rondonotti, M. Pennazio, E. Toth, P. Menchen, M. E. Riccioni, G. D. De Palma, F. Scotto, D. De Looze, T. Pachofsky, I. Tacheci, T. Havelund, G. Couto, A. Trifan, A. Kofokotsios, R. Cannizzaro, E. Perez-Quadrado, R. de Franchis, R. Marmo, A. Pezzoli, C. M. GirelliM. Opezzi, L. De Luca, P. Pantanella, A. Alberani, R. Chiaverini, B. Gonzalez Suarez, S. Fernandez Diez, I. Fernandez Urien, J. Valle, J. Cabriada

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Abstract

Background and study aim: Small-bowel tumors account for 1% - 3% of all gastrointestinal neoplasms. Recent studies with video capsule endoscopy (VCE) suggest that the frequency of these tumors may be substantially higher than previously reported. The aim of the study was to evaluate the frequency, clinical presentation, diagnostic/therapeutic work-up, and endoscopic appearance of small-bowel tumors in a large population of patients undergoing VCE. Patients and methods: Identification by a questionnaire of patients with VCE findings suggesting small-bowel tumors and histological confirmation of the neoplasm seen in 29 centers of 10 European Countries. Results: Of 5129 patients undergoing VCE, 124 (2.4%) had small-bowel tumors (112 primary, 12 metastatic). Among these patients, indications for VCE were: obscure gastrointestinal bleeding (108 patients), abdominal pain (9), search for primary neoplasm (6), diarrhea with malabsorption (1). The main primary small-bowel tumor type was gastrointestinal stromal tumor (GIST) (32%) followed by adenocarcinoma (20 %) and carcinoid (15%); 66% of secondary small-bowel tumors were melanomas. Of the tumors, 80.6% were identified solely on the basis of VCE findings. 55 patients underwent VCE as the third procedure after negative bidirectional endoscopy. The lesions were single in 89.5 % of cases, and multiple in 10.5%. Retention of the capsule occurred in 9.8% of patients with small-bowel tumors. After VCE, 54/124 patients underwent 57 other examinations before treatment; in these patients enteroscopy, when performed, showed a high diagnostic yield. Treatment was surgery in 95% of cases. Conclusions: Our data suggest that VCE detects small-bowel tumors in a small proportion of patients undergoing this examination, but the early use of this tool can shorten the diagnostic work- up and influence the subsequent management of these patients.

Original languageEnglish
Pages (from-to)488-495
Number of pages8
JournalEndoscopy
Volume40
Issue number6
DOIs
Publication statusPublished - Jun 2008

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Capsule Endoscopy
Multicenter Studies
Neoplasms
Gastrointestinal Stromal Tumors
Gastrointestinal Neoplasms
Carcinoid Tumor
Abdominal Pain
Endoscopy
Capsules
Diarrhea
Melanoma
Adenocarcinoma

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Rondonotti, E., Pennazio, M., Toth, E., Menchen, P., Riccioni, M. E., De Palma, G. D., ... Cabriada, J. (2008). Small-bowel neoplasms in patients undergoing video capsule endoscopy: A multicenter European study. Endoscopy, 40(6), 488-495. https://doi.org/10.1055/s-2007-995783

Small-bowel neoplasms in patients undergoing video capsule endoscopy : A multicenter European study. / Rondonotti, Emanuele; Pennazio, M.; Toth, E.; Menchen, P.; Riccioni, M. E.; De Palma, G. D.; Scotto, F.; De Looze, D.; Pachofsky, T.; Tacheci, I.; Havelund, T.; Couto, G.; Trifan, A.; Kofokotsios, A.; Cannizzaro, R.; Perez-Quadrado, E.; de Franchis, R.; Marmo, R.; Pezzoli, A.; Girelli, C. M.; Opezzi, M.; De Luca, L.; Pantanella, P.; Alberani, A.; Chiaverini, R.; Gonzalez Suarez, B.; Fernandez Diez, S.; Fernandez Urien, I.; Valle, J.; Cabriada, J.

In: Endoscopy, Vol. 40, No. 6, 06.2008, p. 488-495.

Research output: Contribution to journalArticle

Rondonotti, E, Pennazio, M, Toth, E, Menchen, P, Riccioni, ME, De Palma, GD, Scotto, F, De Looze, D, Pachofsky, T, Tacheci, I, Havelund, T, Couto, G, Trifan, A, Kofokotsios, A, Cannizzaro, R, Perez-Quadrado, E, de Franchis, R, Marmo, R, Pezzoli, A, Girelli, CM, Opezzi, M, De Luca, L, Pantanella, P, Alberani, A, Chiaverini, R, Gonzalez Suarez, B, Fernandez Diez, S, Fernandez Urien, I, Valle, J & Cabriada, J 2008, 'Small-bowel neoplasms in patients undergoing video capsule endoscopy: A multicenter European study', Endoscopy, vol. 40, no. 6, pp. 488-495. https://doi.org/10.1055/s-2007-995783
Rondonotti E, Pennazio M, Toth E, Menchen P, Riccioni ME, De Palma GD et al. Small-bowel neoplasms in patients undergoing video capsule endoscopy: A multicenter European study. Endoscopy. 2008 Jun;40(6):488-495. https://doi.org/10.1055/s-2007-995783
Rondonotti, Emanuele ; Pennazio, M. ; Toth, E. ; Menchen, P. ; Riccioni, M. E. ; De Palma, G. D. ; Scotto, F. ; De Looze, D. ; Pachofsky, T. ; Tacheci, I. ; Havelund, T. ; Couto, G. ; Trifan, A. ; Kofokotsios, A. ; Cannizzaro, R. ; Perez-Quadrado, E. ; de Franchis, R. ; Marmo, R. ; Pezzoli, A. ; Girelli, C. M. ; Opezzi, M. ; De Luca, L. ; Pantanella, P. ; Alberani, A. ; Chiaverini, R. ; Gonzalez Suarez, B. ; Fernandez Diez, S. ; Fernandez Urien, I. ; Valle, J. ; Cabriada, J. / Small-bowel neoplasms in patients undergoing video capsule endoscopy : A multicenter European study. In: Endoscopy. 2008 ; Vol. 40, No. 6. pp. 488-495.
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abstract = "Background and study aim: Small-bowel tumors account for 1{\%} - 3{\%} of all gastrointestinal neoplasms. Recent studies with video capsule endoscopy (VCE) suggest that the frequency of these tumors may be substantially higher than previously reported. The aim of the study was to evaluate the frequency, clinical presentation, diagnostic/therapeutic work-up, and endoscopic appearance of small-bowel tumors in a large population of patients undergoing VCE. Patients and methods: Identification by a questionnaire of patients with VCE findings suggesting small-bowel tumors and histological confirmation of the neoplasm seen in 29 centers of 10 European Countries. Results: Of 5129 patients undergoing VCE, 124 (2.4{\%}) had small-bowel tumors (112 primary, 12 metastatic). Among these patients, indications for VCE were: obscure gastrointestinal bleeding (108 patients), abdominal pain (9), search for primary neoplasm (6), diarrhea with malabsorption (1). The main primary small-bowel tumor type was gastrointestinal stromal tumor (GIST) (32{\%}) followed by adenocarcinoma (20 {\%}) and carcinoid (15{\%}); 66{\%} of secondary small-bowel tumors were melanomas. Of the tumors, 80.6{\%} were identified solely on the basis of VCE findings. 55 patients underwent VCE as the third procedure after negative bidirectional endoscopy. The lesions were single in 89.5 {\%} of cases, and multiple in 10.5{\%}. Retention of the capsule occurred in 9.8{\%} of patients with small-bowel tumors. After VCE, 54/124 patients underwent 57 other examinations before treatment; in these patients enteroscopy, when performed, showed a high diagnostic yield. Treatment was surgery in 95{\%} of cases. Conclusions: Our data suggest that VCE detects small-bowel tumors in a small proportion of patients undergoing this examination, but the early use of this tool can shorten the diagnostic work- up and influence the subsequent management of these patients.",
author = "Emanuele Rondonotti and M. Pennazio and E. Toth and P. Menchen and Riccioni, {M. E.} and {De Palma}, {G. D.} and F. Scotto and {De Looze}, D. and T. Pachofsky and I. Tacheci and T. Havelund and G. Couto and A. Trifan and A. Kofokotsios and R. Cannizzaro and E. Perez-Quadrado and {de Franchis}, R. and R. Marmo and A. Pezzoli and Girelli, {C. M.} and M. Opezzi and {De Luca}, L. and P. Pantanella and A. Alberani and R. Chiaverini and {Gonzalez Suarez}, B. and {Fernandez Diez}, S. and {Fernandez Urien}, I. and J. Valle and J. Cabriada",
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T1 - Small-bowel neoplasms in patients undergoing video capsule endoscopy

T2 - A multicenter European study

AU - Rondonotti, Emanuele

AU - Pennazio, M.

AU - Toth, E.

AU - Menchen, P.

AU - Riccioni, M. E.

AU - De Palma, G. D.

AU - Scotto, F.

AU - De Looze, D.

AU - Pachofsky, T.

AU - Tacheci, I.

AU - Havelund, T.

AU - Couto, G.

AU - Trifan, A.

AU - Kofokotsios, A.

AU - Cannizzaro, R.

AU - Perez-Quadrado, E.

AU - de Franchis, R.

AU - Marmo, R.

AU - Pezzoli, A.

AU - Girelli, C. M.

AU - Opezzi, M.

AU - De Luca, L.

AU - Pantanella, P.

AU - Alberani, A.

AU - Chiaverini, R.

AU - Gonzalez Suarez, B.

AU - Fernandez Diez, S.

AU - Fernandez Urien, I.

AU - Valle, J.

AU - Cabriada, J.

PY - 2008/6

Y1 - 2008/6

N2 - Background and study aim: Small-bowel tumors account for 1% - 3% of all gastrointestinal neoplasms. Recent studies with video capsule endoscopy (VCE) suggest that the frequency of these tumors may be substantially higher than previously reported. The aim of the study was to evaluate the frequency, clinical presentation, diagnostic/therapeutic work-up, and endoscopic appearance of small-bowel tumors in a large population of patients undergoing VCE. Patients and methods: Identification by a questionnaire of patients with VCE findings suggesting small-bowel tumors and histological confirmation of the neoplasm seen in 29 centers of 10 European Countries. Results: Of 5129 patients undergoing VCE, 124 (2.4%) had small-bowel tumors (112 primary, 12 metastatic). Among these patients, indications for VCE were: obscure gastrointestinal bleeding (108 patients), abdominal pain (9), search for primary neoplasm (6), diarrhea with malabsorption (1). The main primary small-bowel tumor type was gastrointestinal stromal tumor (GIST) (32%) followed by adenocarcinoma (20 %) and carcinoid (15%); 66% of secondary small-bowel tumors were melanomas. Of the tumors, 80.6% were identified solely on the basis of VCE findings. 55 patients underwent VCE as the third procedure after negative bidirectional endoscopy. The lesions were single in 89.5 % of cases, and multiple in 10.5%. Retention of the capsule occurred in 9.8% of patients with small-bowel tumors. After VCE, 54/124 patients underwent 57 other examinations before treatment; in these patients enteroscopy, when performed, showed a high diagnostic yield. Treatment was surgery in 95% of cases. Conclusions: Our data suggest that VCE detects small-bowel tumors in a small proportion of patients undergoing this examination, but the early use of this tool can shorten the diagnostic work- up and influence the subsequent management of these patients.

AB - Background and study aim: Small-bowel tumors account for 1% - 3% of all gastrointestinal neoplasms. Recent studies with video capsule endoscopy (VCE) suggest that the frequency of these tumors may be substantially higher than previously reported. The aim of the study was to evaluate the frequency, clinical presentation, diagnostic/therapeutic work-up, and endoscopic appearance of small-bowel tumors in a large population of patients undergoing VCE. Patients and methods: Identification by a questionnaire of patients with VCE findings suggesting small-bowel tumors and histological confirmation of the neoplasm seen in 29 centers of 10 European Countries. Results: Of 5129 patients undergoing VCE, 124 (2.4%) had small-bowel tumors (112 primary, 12 metastatic). Among these patients, indications for VCE were: obscure gastrointestinal bleeding (108 patients), abdominal pain (9), search for primary neoplasm (6), diarrhea with malabsorption (1). The main primary small-bowel tumor type was gastrointestinal stromal tumor (GIST) (32%) followed by adenocarcinoma (20 %) and carcinoid (15%); 66% of secondary small-bowel tumors were melanomas. Of the tumors, 80.6% were identified solely on the basis of VCE findings. 55 patients underwent VCE as the third procedure after negative bidirectional endoscopy. The lesions were single in 89.5 % of cases, and multiple in 10.5%. Retention of the capsule occurred in 9.8% of patients with small-bowel tumors. After VCE, 54/124 patients underwent 57 other examinations before treatment; in these patients enteroscopy, when performed, showed a high diagnostic yield. Treatment was surgery in 95% of cases. Conclusions: Our data suggest that VCE detects small-bowel tumors in a small proportion of patients undergoing this examination, but the early use of this tool can shorten the diagnostic work- up and influence the subsequent management of these patients.

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