Small bowel obstruction caused by a large B-cell lymphoma in a patient with multicentric Castleman's disease: An unusual occurrence

Isacco Montroni, Elena Sabattini, Eleonora Ramadori, Vidak Koprivica, Giampaolo Ugolini, Francesca Locatelli, Federico Ghignone, Giancarlo Rosati, Mario Taffurelli, Stefano Pileri

Research output: Contribution to journalArticlepeer-review

Abstract

Multicentric Castleman's disease is a rare condition of systemic nonclonal lymph node hyperplasia. Because of its strong association with human herpes virus 8 (HHV8), the multicentric, more aggressive, form may progress to Kaposi sarcoma or non-Hodgkin lymphoma. While surgery is curative in the treatment of localized Castleman's disease, operative treatment of the diffuse form has as yet been unsatisfactory. We report the case of a patient presenting with postprandial vomiting of 1 month duration consistent with partial small bowel obstruction secondary to terminal ileum intussusception. Resection of the small bowel showed a stenosing tumor triggering the intussusception. On pathological examination, the tumor was found to be composed of HHV8-positive plasmablastic lymphoma cells. To our knowledge, this represents the first case of a complication due to the progression of multicentric Castleman's disease requiring surgical intervention for intussusception.

Original languageEnglish
Pages (from-to)434-437
Number of pages4
JournalInternational Journal of Surgical Pathology
Volume22
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • human herpes virus 8
  • intussusception
  • large B-cell lymphoma
  • multicentric Castleman's disease
  • small bowel obstruction

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

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