Componenti monoclonali piccole ma dannose

Translated title of the contribution: Small but harmful monoclonal components

Paolo Milani, Giovanni Palladini, Maria Stella Graziani, Giampaolo Merlini

Research output: Contribution to journalArticlepeer-review


A small B-cell clone can synthesize a toxic monoclonal protein that causes severe organ damage. Diseases caused by these toxic immunoglobulins range from AL amyloidosis, light chain deposition disease and cryoglobulinemia to the POEMS (Polineuropathy, Organomegaly, Endocrinopathy, Monoclonal protein and Skin changes) syndrome. The serum monoclonal components are, in these cases, usually small and difficult to be detected by the commercially available methods. However, an early detection and a correct characterization of the monoclonal component is essential, because misdiagnosis or a delay in diagnosis can prevent the proper treatment of the patient worsening his outcome. Here we present two cases of amyloidosis AL, where the correct diagnosis was facilitated by specific and sensitive techniques. This does not mean that every clinical laboratory should be competent in this field and use these methods routinely, but simply that people should be aware of the problem, so that these clinical conditions can be properly managed.

Translated title of the contributionSmall but harmful monoclonal components
Original languageItalian
Pages (from-to)431-434
Number of pages4
JournalBiochimica Clinica
Issue number5
Publication statusPublished - Oct 2013

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Medical Laboratory Technology


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