Abstract
Small cell carcinoma of the esophagus (SCEC) is a rare tumor with its particular biologic features, distinct from squamous and glandular carcinoma of esophagus. Although initial symptoms can be similar (with metastatic dissemination and paraneoplastic syndromes at presentation more frequent in SCEC), differences in age and sex distribution, tumor location, radiological and endoscopic findings, clinical course and prognosis have been observed between SCEC and other esophageal malignancies. SCEC should be considered a systemic disease, and by analogy to bronchogenic small cell carcinoma, multi- modality approach including chemotherapy is recommended. In patients with limited disease, irradiation or surgery should be offered after induction chemotherapy to manage local disease. However, optimal treatment schedule has not yet been defined. In the future, registration of all SCEC cases and careful analysis of prognostic factors in the larger multi-institutional series could contribute to further progress in treatment outcome.
| Original language | English |
|---|---|
| Pages (from-to) | 7-11 |
| Number of pages | 5 |
| Journal | Neoplasma |
| Volume | 46 |
| Issue number | 1 |
| Publication status | Published - 1999 |
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Keywords
- Chemotherapy
- Prognosis
- Radiotherapy
- Small cell esophageal cancer
- Surgery
ASJC Scopus subject areas
- Cancer Research
Cite this
Small cell carcinoma of the esophagus. / Jereczek-Fossa, B.; Airoldi, M.; Gribaudo, S.; Ruo Redda, M. G.; Valente, G.; Orecchia, R.
In: Neoplasma, Vol. 46, No. 1, 1999, p. 7-11.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Small cell carcinoma of the esophagus
AU - Jereczek-Fossa, B.
AU - Airoldi, M.
AU - Gribaudo, S.
AU - Ruo Redda, M. G.
AU - Valente, G.
AU - Orecchia, R.
PY - 1999
Y1 - 1999
N2 - Small cell carcinoma of the esophagus (SCEC) is a rare tumor with its particular biologic features, distinct from squamous and glandular carcinoma of esophagus. Although initial symptoms can be similar (with metastatic dissemination and paraneoplastic syndromes at presentation more frequent in SCEC), differences in age and sex distribution, tumor location, radiological and endoscopic findings, clinical course and prognosis have been observed between SCEC and other esophageal malignancies. SCEC should be considered a systemic disease, and by analogy to bronchogenic small cell carcinoma, multi- modality approach including chemotherapy is recommended. In patients with limited disease, irradiation or surgery should be offered after induction chemotherapy to manage local disease. However, optimal treatment schedule has not yet been defined. In the future, registration of all SCEC cases and careful analysis of prognostic factors in the larger multi-institutional series could contribute to further progress in treatment outcome.
AB - Small cell carcinoma of the esophagus (SCEC) is a rare tumor with its particular biologic features, distinct from squamous and glandular carcinoma of esophagus. Although initial symptoms can be similar (with metastatic dissemination and paraneoplastic syndromes at presentation more frequent in SCEC), differences in age and sex distribution, tumor location, radiological and endoscopic findings, clinical course and prognosis have been observed between SCEC and other esophageal malignancies. SCEC should be considered a systemic disease, and by analogy to bronchogenic small cell carcinoma, multi- modality approach including chemotherapy is recommended. In patients with limited disease, irradiation or surgery should be offered after induction chemotherapy to manage local disease. However, optimal treatment schedule has not yet been defined. In the future, registration of all SCEC cases and careful analysis of prognostic factors in the larger multi-institutional series could contribute to further progress in treatment outcome.
KW - Chemotherapy
KW - Prognosis
KW - Radiotherapy
KW - Small cell esophageal cancer
KW - Surgery
UR - http://www.scopus.com/inward/record.url?scp=0032920276&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032920276&partnerID=8YFLogxK
M3 - Article
C2 - 10355527
AN - SCOPUS:0032920276
VL - 46
SP - 7
EP - 11
JO - Neoplasma
JF - Neoplasma
SN - 0028-2685
IS - 1
ER -