Mesotelioma a piccole cellule della pleura: Descrizione di un caso

Translated title of the contribution: Small cell mesothelioma of the pleura: A case report

A. Cavazza, G. Rossi, L. Agostini, N. Facciolongo, L. De Marco, I. Putrino, G. Gardini

Research output: Contribution to journalArticle

Abstract

A case of mesothelioma with a small cell component in a 53-year-old, non-smoker woman. The patient had a history of asbestos exposure, and presented with thoracic pain. A total body computed tomogram showed a left pleural effusion and a 7.5-cm pleural mass. Thoracoscopy revealed a diffuse nodular thickening of the left parietal pleura, and a biopsy was performed. The patient died of the disease 4 months after diagnosis. Microscopically, the pleural neoplasm was composed of three different components: 40% of the tumor showed the classic histology of a malignant epithelial mesothelioma, 40% was composed of small- to medium-sized cells with open nuclear chromatin, evident nucleoli and high mitotic activity, and 20% of the neoplasm was indistinguishable from a small cell carcinoma. Immunohistochemically, the first component was diffusely and strongly positive for cytokeratin AE1/AE3, cytokeratin CAM 5.2 and EMA, focally positive for BER-EP4, and negative for CD15, B 72.3, CEA, LCA, chromogranin, synaptophysin, TTF-1 and CD99. The cells of the second component were positive only for cytokeratin AE1/AE3 and cytokeratin CAM 5.2, and the elements of the third component were negative for all the antibodies tested. Pleural mesothelioma with a small cell component is rare. The most useful parameters to distinguish it from other small cell malignancies that may involve the pleura, particulary small cell carcinoma of pulmonary origin, are discussed.

Original languageItalian
Pages (from-to)247-252
Number of pages6
JournalPathologica
Volume94
Issue number5
Publication statusPublished - Oct 2002

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Pleura
Mesothelioma
Cellular Structures
Small Cell Carcinoma
Keratins
Pleural Neoplasms
Chromogranins
Neoplasms
Thoracoscopy
Synaptophysin
Asbestos
Pleural Effusion
Chest Pain
Chromatin
Histology
Biopsy
Lung
Antibodies
CAM 5.2 antigen

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Cavazza, A., Rossi, G., Agostini, L., Facciolongo, N., De Marco, L., Putrino, I., & Gardini, G. (2002). Mesotelioma a piccole cellule della pleura: Descrizione di un caso. Pathologica, 94(5), 247-252.

Mesotelioma a piccole cellule della pleura : Descrizione di un caso. / Cavazza, A.; Rossi, G.; Agostini, L.; Facciolongo, N.; De Marco, L.; Putrino, I.; Gardini, G.

In: Pathologica, Vol. 94, No. 5, 10.2002, p. 247-252.

Research output: Contribution to journalArticle

Cavazza, A, Rossi, G, Agostini, L, Facciolongo, N, De Marco, L, Putrino, I & Gardini, G 2002, 'Mesotelioma a piccole cellule della pleura: Descrizione di un caso', Pathologica, vol. 94, no. 5, pp. 247-252.
Cavazza A, Rossi G, Agostini L, Facciolongo N, De Marco L, Putrino I et al. Mesotelioma a piccole cellule della pleura: Descrizione di un caso. Pathologica. 2002 Oct;94(5):247-252.
Cavazza, A. ; Rossi, G. ; Agostini, L. ; Facciolongo, N. ; De Marco, L. ; Putrino, I. ; Gardini, G. / Mesotelioma a piccole cellule della pleura : Descrizione di un caso. In: Pathologica. 2002 ; Vol. 94, No. 5. pp. 247-252.
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