Small cell neuroendocrine cervical carcinoma with 1-year follow-up: Case report and review

Giuseppe Bifulco, Vincenzo Dario Mandato, Pierluigi Giampaolino, Roberto Piccoli, Luigi Insabato, Nicoletta De Rosa, Carmine Nappi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Small cell neuroendocrine cervical carcinoma (SCNCC) is a rare tumor that comprises 1-3% of cervical tumors. SCNCC exhibits clinical and biological characteristics of both cervical neoplasm (such as local aggressiveness and involvement of papillomavirus) and neuroendocrine small cell cancer of any site (such as early dissemination of the disease and loss of heterozygozity at different loci) making it an original nosologic entity. There is no unanimous opinion regarding the optimal management strategy. Case Report: A 48-year-old Caucasian woman, para 3, referred postmenopausal bleeding of 2 months' duration. Preoperative investigation diagnosed an infiltrating squamous carcinoma of the cervix. A radical hysterectomy with bilateral salpingo-oophorectomy, pelvic and paraaortic lymphadenectomy were performed. Final diagnosis was SCNCC (FIGO stage III B) and therefore adjuvant radiochemotherapy was given. At 1-year follow-up the patient was free of disease. Conclusion: Despite the retrospective studies and case reports reported, in literature the best modality of treatment remains controversial. Multicenter clinical trials are needed to determine a univocal and effective treatment for SCNCC in order to achieve significant survival benefit.

Original languageEnglish
Pages (from-to)477-484
Number of pages8
JournalAnticancer Research
Volume29
Issue number2
Publication statusPublished - Feb 2009

Fingerprint

Neuroendocrine Carcinoma
Small Cell Carcinoma
Adjuvant Chemoradiotherapy
Neoplasms
Neuroendocrine Cells
Ovariectomy
Lymph Node Excision
Hysterectomy
Cervix Uteri
Uterine Cervical Neoplasms
Multicenter Studies
Squamous Cell Carcinoma
Retrospective Studies
Clinical Trials
Hemorrhage
Survival
Therapeutics

Keywords

  • Prognostic factors
  • Small cell neuroendocrine cervical carcinoma
  • Treatment

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Bifulco, G., Mandato, V. D., Giampaolino, P., Piccoli, R., Insabato, L., De Rosa, N., & Nappi, C. (2009). Small cell neuroendocrine cervical carcinoma with 1-year follow-up: Case report and review. Anticancer Research, 29(2), 477-484.

Small cell neuroendocrine cervical carcinoma with 1-year follow-up : Case report and review. / Bifulco, Giuseppe; Mandato, Vincenzo Dario; Giampaolino, Pierluigi; Piccoli, Roberto; Insabato, Luigi; De Rosa, Nicoletta; Nappi, Carmine.

In: Anticancer Research, Vol. 29, No. 2, 02.2009, p. 477-484.

Research output: Contribution to journalArticle

Bifulco, G, Mandato, VD, Giampaolino, P, Piccoli, R, Insabato, L, De Rosa, N & Nappi, C 2009, 'Small cell neuroendocrine cervical carcinoma with 1-year follow-up: Case report and review', Anticancer Research, vol. 29, no. 2, pp. 477-484.
Bifulco G, Mandato VD, Giampaolino P, Piccoli R, Insabato L, De Rosa N et al. Small cell neuroendocrine cervical carcinoma with 1-year follow-up: Case report and review. Anticancer Research. 2009 Feb;29(2):477-484.
Bifulco, Giuseppe ; Mandato, Vincenzo Dario ; Giampaolino, Pierluigi ; Piccoli, Roberto ; Insabato, Luigi ; De Rosa, Nicoletta ; Nappi, Carmine. / Small cell neuroendocrine cervical carcinoma with 1-year follow-up : Case report and review. In: Anticancer Research. 2009 ; Vol. 29, No. 2. pp. 477-484.
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