Small doses of remifentanil or sufentanil for blunting cardiovascular changes induced by tracheal intubation: A double-blind comparison

A. Casati, G. Fanelli, A. Albertin, F. Deni, G. Danelli, F. Grifoni, G. Torri

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background and objective: To compare the effects on cardiovascular changes induced by tracheal intubation when small doses of either remifentanil or sufentanil are used in the presence of midazolam. Methods: Thirty normotensive, ASA physical status I-II patients, receiving general anaesthesia for major abdominal surgery, received an intravenous midazolam premedication (0.05 mg kg-1) 10 min before induction. They were randomly allocated to receive in a double-blind fashion an intravenous bolus of either(a) remifentanil given as a bolus dose 1 μg kg-1 (n = 15), or else (b) sufentanil 0.1 μg kg-1 infused over 60 s (n = 15). In each instance this loading dose was followed by a continuous intravenous infusion (0.1 μg kg-1 min-1 or 0.01 μg kg-1 min-1 of remifentanil or sufentanil, respectively). General anaesthesia was induced with propofol (2 mg kg-1), followed by atracurium besilate (0.5 mg kg-1) to facilitate tracheal intubation. Following intubation, the lungs were mechanically ventilated with a 60% nitrous oxide in oxygen mixture and a 1% inspired sevoflurane. Results: Arterial pressure and heart rate were recorded before induction of anaesthesia (baseline), immediately before intubation, immediately after tracheal intubation and every minute for the first five minutes thereafter. No differences in systolic and diastolic arterial pressures were observed between the two groups. At the end of the study period, systolic and diastolic pressures slightly decreased from preinduction values in both groups. Four patients in the remifentanil group (26%) and five patients in sufentanil group (33%) showed at least one systolic pressure value

Original languageEnglish
Pages (from-to)108-112
Number of pages5
JournalEuropean Journal of Anaesthesiology
Volume18
Issue number2
DOIs
Publication statusPublished - 2001

Fingerprint

Sufentanil
Intubation
Blood Pressure
Midazolam
General Anesthesia
Arterial Pressure
Atracurium
Premedication
Nitrous Oxide
Propofol
Intravenous Infusions
Anesthesia
Heart Rate
remifentanil
Oxygen
Lung

Keywords

  • Anaesthetics, inhalational, sevoflurane
  • Analgesics, narcotics, remifentanil, sufentanil
  • Intubation, intratracheal
  • Monitoring, cardiovascular

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Small doses of remifentanil or sufentanil for blunting cardiovascular changes induced by tracheal intubation : A double-blind comparison. / Casati, A.; Fanelli, G.; Albertin, A.; Deni, F.; Danelli, G.; Grifoni, F.; Torri, G.

In: European Journal of Anaesthesiology, Vol. 18, No. 2, 2001, p. 108-112.

Research output: Contribution to journalArticle

Casati, A. ; Fanelli, G. ; Albertin, A. ; Deni, F. ; Danelli, G. ; Grifoni, F. ; Torri, G. / Small doses of remifentanil or sufentanil for blunting cardiovascular changes induced by tracheal intubation : A double-blind comparison. In: European Journal of Anaesthesiology. 2001 ; Vol. 18, No. 2. pp. 108-112.
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abstract = "Background and objective: To compare the effects on cardiovascular changes induced by tracheal intubation when small doses of either remifentanil or sufentanil are used in the presence of midazolam. Methods: Thirty normotensive, ASA physical status I-II patients, receiving general anaesthesia for major abdominal surgery, received an intravenous midazolam premedication (0.05 mg kg-1) 10 min before induction. They were randomly allocated to receive in a double-blind fashion an intravenous bolus of either(a) remifentanil given as a bolus dose 1 μg kg-1 (n = 15), or else (b) sufentanil 0.1 μg kg-1 infused over 60 s (n = 15). In each instance this loading dose was followed by a continuous intravenous infusion (0.1 μg kg-1 min-1 or 0.01 μg kg-1 min-1 of remifentanil or sufentanil, respectively). General anaesthesia was induced with propofol (2 mg kg-1), followed by atracurium besilate (0.5 mg kg-1) to facilitate tracheal intubation. Following intubation, the lungs were mechanically ventilated with a 60{\%} nitrous oxide in oxygen mixture and a 1{\%} inspired sevoflurane. Results: Arterial pressure and heart rate were recorded before induction of anaesthesia (baseline), immediately before intubation, immediately after tracheal intubation and every minute for the first five minutes thereafter. No differences in systolic and diastolic arterial pressures were observed between the two groups. At the end of the study period, systolic and diastolic pressures slightly decreased from preinduction values in both groups. Four patients in the remifentanil group (26{\%}) and five patients in sufentanil group (33{\%}) showed at least one systolic pressure value",
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T1 - Small doses of remifentanil or sufentanil for blunting cardiovascular changes induced by tracheal intubation

T2 - A double-blind comparison

AU - Casati, A.

AU - Fanelli, G.

AU - Albertin, A.

AU - Deni, F.

AU - Danelli, G.

AU - Grifoni, F.

AU - Torri, G.

PY - 2001

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AB - Background and objective: To compare the effects on cardiovascular changes induced by tracheal intubation when small doses of either remifentanil or sufentanil are used in the presence of midazolam. Methods: Thirty normotensive, ASA physical status I-II patients, receiving general anaesthesia for major abdominal surgery, received an intravenous midazolam premedication (0.05 mg kg-1) 10 min before induction. They were randomly allocated to receive in a double-blind fashion an intravenous bolus of either(a) remifentanil given as a bolus dose 1 μg kg-1 (n = 15), or else (b) sufentanil 0.1 μg kg-1 infused over 60 s (n = 15). In each instance this loading dose was followed by a continuous intravenous infusion (0.1 μg kg-1 min-1 or 0.01 μg kg-1 min-1 of remifentanil or sufentanil, respectively). General anaesthesia was induced with propofol (2 mg kg-1), followed by atracurium besilate (0.5 mg kg-1) to facilitate tracheal intubation. Following intubation, the lungs were mechanically ventilated with a 60% nitrous oxide in oxygen mixture and a 1% inspired sevoflurane. Results: Arterial pressure and heart rate were recorded before induction of anaesthesia (baseline), immediately before intubation, immediately after tracheal intubation and every minute for the first five minutes thereafter. No differences in systolic and diastolic arterial pressures were observed between the two groups. At the end of the study period, systolic and diastolic pressures slightly decreased from preinduction values in both groups. Four patients in the remifentanil group (26%) and five patients in sufentanil group (33%) showed at least one systolic pressure value

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KW - Analgesics, narcotics, remifentanil, sufentanil

KW - Intubation, intratracheal

KW - Monitoring, cardiovascular

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