Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment

Irene Bertolini, Jagadish C. Ghosh, Andrew V. Kossenkov, Sudheer Mulugu, Shiv Ram Krishn, Valentina Vaira, Jun Qin, Edward F. Plow, Lucia R. Languino, Dario C. Altieri

Research output: Contribution to journalArticlepeer-review

Abstract

The communication between tumor cells and their neighbors is important for disease progression. Here, Bertolini et al. show that hypoxic breast cancer cells release small extracellular vesicles that introduce multiple malignant changes in the normal mammary epithelium via reprogramming of mitochondrial functions. This pathway may promote local breast cancer recurrences.

Original languageEnglish
Pages (from-to)163-177.e6
JournalDevelopmental Cell
Volume55
Issue number2
DOIs
Publication statusPublished - 2020

Keywords

  • breast cancer
  • extracellular vesicles
  • hypoxia
  • mitochondria
  • morphogenesis
  • normal mammary epithelium
  • transformation

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment'. Together they form a unique fingerprint.

Cite this