Small fiber neuropathy in female patients with fabry disease

Rocco Liguori, Vitantonio Di Stasi, Enrico Bugiardini, Renzo Mignani, Alessandro Burlina, Walter Borsini, Agostino Baruzzi, Pasquale Montagna, Vincenzo Donadio

Research output: Contribution to journalArticle

Abstract

Recent studies suggest that heterozygous female Fabry disease (FD) patients develop peripheral neuropathy. We used skin biopsy to define somatic and autonomic peripheral nerve characteristics in 21 females with FD who were mainly asymptomatic and had normal renal function. Somatic epidermal and dermal autonomic nerve fiber reductions were found, prevalently in the leg, and no differences were found between symptomatic and asymptomatic individuals. Our findings suggest that females with FD, although asymptomatic, may have somatic and autonomic small fiber neuropathy.

Original languageEnglish
Pages (from-to)409-412
Number of pages4
JournalMuscle and Nerve
Volume41
Issue number3
DOIs
Publication statusPublished - Mar 2010

Fingerprint

Fabry Disease
Autonomic Pathways
Skin
Peripheral Nervous System Diseases
Peripheral Nerves
Nerve Fibers
Leg
Kidney
Biopsy
Small Fiber Neuropathy

Keywords

  • Autonomic dysfunction
  • Fabry disease
  • Female
  • Skin biopsy
  • Small fiber neuropathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)
  • Physiology

Cite this

Liguori, R., Di Stasi, V., Bugiardini, E., Mignani, R., Burlina, A., Borsini, W., ... Donadio, V. (2010). Small fiber neuropathy in female patients with fabry disease. Muscle and Nerve, 41(3), 409-412. https://doi.org/10.1002/mus.21606

Small fiber neuropathy in female patients with fabry disease. / Liguori, Rocco; Di Stasi, Vitantonio; Bugiardini, Enrico; Mignani, Renzo; Burlina, Alessandro; Borsini, Walter; Baruzzi, Agostino; Montagna, Pasquale; Donadio, Vincenzo.

In: Muscle and Nerve, Vol. 41, No. 3, 03.2010, p. 409-412.

Research output: Contribution to journalArticle

Liguori, R, Di Stasi, V, Bugiardini, E, Mignani, R, Burlina, A, Borsini, W, Baruzzi, A, Montagna, P & Donadio, V 2010, 'Small fiber neuropathy in female patients with fabry disease', Muscle and Nerve, vol. 41, no. 3, pp. 409-412. https://doi.org/10.1002/mus.21606
Liguori R, Di Stasi V, Bugiardini E, Mignani R, Burlina A, Borsini W et al. Small fiber neuropathy in female patients with fabry disease. Muscle and Nerve. 2010 Mar;41(3):409-412. https://doi.org/10.1002/mus.21606
Liguori, Rocco ; Di Stasi, Vitantonio ; Bugiardini, Enrico ; Mignani, Renzo ; Burlina, Alessandro ; Borsini, Walter ; Baruzzi, Agostino ; Montagna, Pasquale ; Donadio, Vincenzo. / Small fiber neuropathy in female patients with fabry disease. In: Muscle and Nerve. 2010 ; Vol. 41, No. 3. pp. 409-412.
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