Small fibers, large impact: Quality of life in small-fiber neuropathy

Mayienne Bakkers, Catharina G. Faber, Janneke G J Hoeijmakers, Giuseppe Lauria, Ingemar S J Merkies

Research output: Contribution to journalArticlepeer-review


Introduction: The impact of small-fiber neuropathy (SFN) on patients' quality of life (QOL) has not been studied extensively. Our aim was to determine the impact of SFN on QOL and examine possible determinants. Methods: We examined a total of 265 patients diagnosed with SFN. The SFN Symptoms Inventory Questionnaire (SFN-SIQ), the pain Visual Analog Scale (VAS), and the generic SF-36 Health Survey were assessed. Regression studies were undertaken to evaluate determinants of functioning. Results: SFN patients demonstrated a severe overall reduction in QOL. The biggest deficits were in Role Functioning-Physical, Body Pain, and Physical Component Summary (PCS) scores. VAS scores, changed sweating pattern, dry mouth, and age were the strongest predictors for PCS, explaining 32% of the QOL decrease. Conclusions: SFN leads to a reduction in overall QOL. The presence of pain and some autonomic symptoms explained only a small portion of the findings.

Original languageEnglish
Pages (from-to)329-336
Number of pages8
JournalMuscle and Nerve
Issue number3
Publication statusPublished - 2014


  • Clinimetric evaluation
  • Pain
  • Polyneuropathy
  • Quality of life
  • Small-fiber neuropathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)
  • Physiology


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