Small fibre involvement in multifocal motor neuropathy explored with sudoscan: a single-centre experience

Marco Luigetti, Silvia Giovannini, Angela Romano, Giulia Bisogni, Francesco Barbato, Andrea Di Paolantonio, Serenella Servidei, Giuseppe Granata, Mario Sabatelli

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Multifocal motor neuropathy (MMN) is a rare inflammatory neuropathy, clinically characterized by exclusive motor involvement. We wished to evaluate the possible presence of sensory dysfunction, including the evaluation of small fibres, after a long-term disease course. Patients and methods: seven MMN patients, regularly followed in our Neurology Department, underwent clinical evaluation, neurophysiological examination by nerve conduction studies (NCSs), and Sudoscan. We compared neurophysiological data with a group of patients with other disorders of the peripheral nervous system. Results: NCSs showed a reduction of sensory nerve action potential amplitude in 2/7 MMN patients. Sudoscan showed borderline electrochemical skin conductance (ESC) values in 3/7 MMN patients (two of them with abnormal sensory NCSs). Conclusions: Our results confirm that sensory involvement may be found in some MMN after a long-term disease course, and it could also involve the small fibres.

Original languageEnglish
Article number755
JournalDiagnostics
Volume10
Issue number10
DOIs
Publication statusPublished - Oct 2020

Keywords

  • Multifocal motor neuropathy
  • Polyneuropathy
  • Sensory involvement
  • Small fibres
  • Sudoscan

ASJC Scopus subject areas

  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Small fibre involvement in multifocal motor neuropathy explored with sudoscan: a single-centre experience'. Together they form a unique fingerprint.

Cite this