TY - JOUR
T1 - Small fibre involvement in multifocal motor neuropathy explored with sudoscan
T2 - a single-centre experience
AU - Luigetti, Marco
AU - Giovannini, Silvia
AU - Romano, Angela
AU - Bisogni, Giulia
AU - Barbato, Francesco
AU - Paolantonio, Andrea Di
AU - Servidei, Serenella
AU - Granata, Giuseppe
AU - Sabatelli, Mario
N1 - Funding Information:
Conflicts of Interest: Luigetti received financial grants (honoraria and speaking) from Ackea, Alnylam and Pfizer, and travel grants from Ackea, Alnylam, Pfizer, Kedrion, Csl Behring, and Grifols; Giovannini has none potential conflicts of interest to be disclosed; Romano received travel grants from Pfizer and Csl Behring, and financial grant from Akcea; Bisogni received financial grants (honoraria and speaking) from Alnylam, and travel grants from Pfizer, Alnylam and Grifols; Barbato has none potential conflicts of interest to be disclosed; Di Paolantonio received travel grants from Pfizer; Servidei has none potential conflicts of interest to be disclosed; Granata has none potential conflicts of interest to be disclosed; Sabatelli received financial grants (honoraria and speaking) from Ackea and Alnylam, and travel grants from Grifols. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
Publisher Copyright:
© 2020 by the authors.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/10
Y1 - 2020/10
N2 - Objective: Multifocal motor neuropathy (MMN) is a rare inflammatory neuropathy, clinically characterized by exclusive motor involvement. We wished to evaluate the possible presence of sensory dysfunction, including the evaluation of small fibres, after a long-term disease course. Patients and methods: seven MMN patients, regularly followed in our Neurology Department, underwent clinical evaluation, neurophysiological examination by nerve conduction studies (NCSs), and Sudoscan. We compared neurophysiological data with a group of patients with other disorders of the peripheral nervous system. Results: NCSs showed a reduction of sensory nerve action potential amplitude in 2/7 MMN patients. Sudoscan showed borderline electrochemical skin conductance (ESC) values in 3/7 MMN patients (two of them with abnormal sensory NCSs). Conclusions: Our results confirm that sensory involvement may be found in some MMN after a long-term disease course, and it could also involve the small fibres.
AB - Objective: Multifocal motor neuropathy (MMN) is a rare inflammatory neuropathy, clinically characterized by exclusive motor involvement. We wished to evaluate the possible presence of sensory dysfunction, including the evaluation of small fibres, after a long-term disease course. Patients and methods: seven MMN patients, regularly followed in our Neurology Department, underwent clinical evaluation, neurophysiological examination by nerve conduction studies (NCSs), and Sudoscan. We compared neurophysiological data with a group of patients with other disorders of the peripheral nervous system. Results: NCSs showed a reduction of sensory nerve action potential amplitude in 2/7 MMN patients. Sudoscan showed borderline electrochemical skin conductance (ESC) values in 3/7 MMN patients (two of them with abnormal sensory NCSs). Conclusions: Our results confirm that sensory involvement may be found in some MMN after a long-term disease course, and it could also involve the small fibres.
KW - Multifocal motor neuropathy
KW - Polyneuropathy
KW - Sensory involvement
KW - Small fibres
KW - Sudoscan
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U2 - 10.3390/diagnostics10100755
DO - 10.3390/diagnostics10100755
M3 - Article
AN - SCOPUS:85092250715
VL - 10
JO - Diagnostics
JF - Diagnostics
SN - 2075-4418
IS - 10
M1 - 755
ER -