Small fibre neuropathies

Research output: Contribution to journalArticle

Abstract

Purpose of review: To summarize the recent advances in aetiology, diagnostic assessment, and treatment of small fibre neuropathies. Recent findings: New causes of small fibre neuropathy have been recognized and advances in neurophysiologic and neuropathologic techniques for investigating small fibres have been made, increasing the interest in this field. In particular, skin biopsy proved to be a sensitive method to diagnose small fibre neuropathy, ft allows the detection of subclinical abnormalities of peripheral nerve function in patients with diabetes and tongue denervation in patients with burning mouth syndrome. This technique has also been used to demonstrate the neuroprotective effect of erythropoietin in experimental models of neuropathy. Among nonconventional neurophysiologic techniques for investigating small fibres, laser-evoked potential and contact heat-evoked potential stimulators have been developed and deserve particular interest Several trials on neuropathic pain that is a typical feature of small fibre neuropathies have been performed and guidelines have recently been published. Summary: Detection of small fibre impairment allows earlier diagnosis of neuropathy and could be used as an outcome measure in future regenerative neuropathy trials. Standardization of skin biopsy can have an important impact on clinical practice and research. Further studies are needed to assess the reliability of current neurophysiologic techniques for testing small fibre function in peripheral neuropathies and the correlation with well established neuropathologic examination.

Original languageEnglish
Pages (from-to)591-597
Number of pages7
JournalCurrent Opinion in Neurology
Volume18
Issue number5
Publication statusPublished - Oct 2005

Fingerprint

Burning Mouth Syndrome
Biopsy
Skin
Neuralgia
Neuroprotective Agents
Peripheral Nervous System Diseases
Denervation
Erythropoietin
Peripheral Nerves
Evoked Potentials
Tongue
Early Diagnosis
Theoretical Models
Hot Temperature
Outcome Assessment (Health Care)
Guidelines
Small Fiber Neuropathy
Research
Therapeutics
Laser-Evoked Potentials

Keywords

  • Autonomic neuropathy
  • Nerve conduction study
  • Painful neuropathy
  • Skin biopsy
  • Small fibre neuropathy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Small fibre neuropathies. / Lauria, Giuseppe.

In: Current Opinion in Neurology, Vol. 18, No. 5, 10.2005, p. 591-597.

Research output: Contribution to journalArticle

Lauria, G 2005, 'Small fibre neuropathies', Current Opinion in Neurology, vol. 18, no. 5, pp. 591-597.
Lauria, Giuseppe. / Small fibre neuropathies. In: Current Opinion in Neurology. 2005 ; Vol. 18, No. 5. pp. 591-597.
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