Small hepatocellular carcinoma: Treatment with radio-frequency ablation versus ethanol injection

Tito Livraghi, S. Nahum Goldberg, Sergio Lazzaroni, Franca Meloni, Luigi Solbiati, G. Scott Gazelle

Research output: Contribution to journalArticle

Abstract

PURPOSE: To compare the effectiveness of radio-frequency (RF) ablation with that of percutaneous ethanol injection in the treatment of small hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Eighty-six patients with 112 small (≤3-cm-diameter) HCCs underwent RF ablation (42 patients with 52 tumors) or percutaneous ethanol injection (44 patients with 60 tumors). Therapeutic efficacy was evaluated with dual-phase spiral computed tomography performed at least 4 months after treatment. RESULTS: Complete necrosis was achieved in 47 of 52 tumors with RF ablation (90%) and in 48 of 60 tumors with percutaneous ethanol injection (80%). These results were obtained with an average of 1.2 sessions per tumor with RF ablation and 4.8 sessions per tumor with percutaneous ethanol injection. One major complication (hemothorax that required drainage) and four minor complications (intraperitoneal bleeding, hemobilia, pleural effusion, cholecystitis) occurred in patients treated with RF ablation; no complications occurred in patients treated with percutaneous ethanol injection. CONCLUSION: RF ablation results in a higher rate of complete necrosis and requires fewer treatment sessions than percutaneous ethanol injection. However, the complication rate is higher with RF ablation than with percutaneous ethanol injection. RF ablation is the treatment of choice for most patients with HCC.

Original languageEnglish
Pages (from-to)655-661
Number of pages7
JournalRadiology
Volume210
Issue number3
Publication statusPublished - Mar 1999

Fingerprint

Radio
Hepatocellular Carcinoma
Ethanol
Injections
Neoplasms
Therapeutics
Necrosis
Hemobilia
Hemothorax
Cholecystitis
Spiral Computed Tomography
Pleural Effusion
Drainage
Hemorrhage

Keywords

  • Alcohol
  • Liver neoplasms, therapy
  • Liver, interventional procedure
  • Radiofrequency (RF) ablation

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Livraghi, T., Goldberg, S. N., Lazzaroni, S., Meloni, F., Solbiati, L., & Gazelle, G. S. (1999). Small hepatocellular carcinoma: Treatment with radio-frequency ablation versus ethanol injection. Radiology, 210(3), 655-661.

Small hepatocellular carcinoma : Treatment with radio-frequency ablation versus ethanol injection. / Livraghi, Tito; Goldberg, S. Nahum; Lazzaroni, Sergio; Meloni, Franca; Solbiati, Luigi; Gazelle, G. Scott.

In: Radiology, Vol. 210, No. 3, 03.1999, p. 655-661.

Research output: Contribution to journalArticle

Livraghi, T, Goldberg, SN, Lazzaroni, S, Meloni, F, Solbiati, L & Gazelle, GS 1999, 'Small hepatocellular carcinoma: Treatment with radio-frequency ablation versus ethanol injection', Radiology, vol. 210, no. 3, pp. 655-661.
Livraghi T, Goldberg SN, Lazzaroni S, Meloni F, Solbiati L, Gazelle GS. Small hepatocellular carcinoma: Treatment with radio-frequency ablation versus ethanol injection. Radiology. 1999 Mar;210(3):655-661.
Livraghi, Tito ; Goldberg, S. Nahum ; Lazzaroni, Sergio ; Meloni, Franca ; Solbiati, Luigi ; Gazelle, G. Scott. / Small hepatocellular carcinoma : Treatment with radio-frequency ablation versus ethanol injection. In: Radiology. 1999 ; Vol. 210, No. 3. pp. 655-661.
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N2 - PURPOSE: To compare the effectiveness of radio-frequency (RF) ablation with that of percutaneous ethanol injection in the treatment of small hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Eighty-six patients with 112 small (≤3-cm-diameter) HCCs underwent RF ablation (42 patients with 52 tumors) or percutaneous ethanol injection (44 patients with 60 tumors). Therapeutic efficacy was evaluated with dual-phase spiral computed tomography performed at least 4 months after treatment. RESULTS: Complete necrosis was achieved in 47 of 52 tumors with RF ablation (90%) and in 48 of 60 tumors with percutaneous ethanol injection (80%). These results were obtained with an average of 1.2 sessions per tumor with RF ablation and 4.8 sessions per tumor with percutaneous ethanol injection. One major complication (hemothorax that required drainage) and four minor complications (intraperitoneal bleeding, hemobilia, pleural effusion, cholecystitis) occurred in patients treated with RF ablation; no complications occurred in patients treated with percutaneous ethanol injection. CONCLUSION: RF ablation results in a higher rate of complete necrosis and requires fewer treatment sessions than percutaneous ethanol injection. However, the complication rate is higher with RF ablation than with percutaneous ethanol injection. RF ablation is the treatment of choice for most patients with HCC.

AB - PURPOSE: To compare the effectiveness of radio-frequency (RF) ablation with that of percutaneous ethanol injection in the treatment of small hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Eighty-six patients with 112 small (≤3-cm-diameter) HCCs underwent RF ablation (42 patients with 52 tumors) or percutaneous ethanol injection (44 patients with 60 tumors). Therapeutic efficacy was evaluated with dual-phase spiral computed tomography performed at least 4 months after treatment. RESULTS: Complete necrosis was achieved in 47 of 52 tumors with RF ablation (90%) and in 48 of 60 tumors with percutaneous ethanol injection (80%). These results were obtained with an average of 1.2 sessions per tumor with RF ablation and 4.8 sessions per tumor with percutaneous ethanol injection. One major complication (hemothorax that required drainage) and four minor complications (intraperitoneal bleeding, hemobilia, pleural effusion, cholecystitis) occurred in patients treated with RF ablation; no complications occurred in patients treated with percutaneous ethanol injection. CONCLUSION: RF ablation results in a higher rate of complete necrosis and requires fewer treatment sessions than percutaneous ethanol injection. However, the complication rate is higher with RF ablation than with percutaneous ethanol injection. RF ablation is the treatment of choice for most patients with HCC.

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