Small hypothalamic hamartomas and gelastic seizures

Salvatore Striano, Pasquale Striano, Sossio Cirillo, Cristoforo Nocerino, Leonilda Bilo, Roberta Meo, Patrizia Ruosi, Patrizia Boccella, Francesco Briganti

Research output: Contribution to journalArticlepeer-review


Purpose: To describe the clinical history of patients with gelastic seizures (GSs) related to small-size hypothalamic hamartomas (HHs), and to show some of these unusual seizures. Material and methods: Patients with GSs and the MRI finding of HH <1 cm diameter. Ictal EEG or video EEG are required. Results: Three patients, among 6 with GSs and HH, had a small sessile HH. None of them had a history of precocious puberty, nor any relevant cognitive defects. All patients suffered from other seizure types, in addition to GSs. GSs were drug-resistant in all cases. Conclusion: Since small, not easily recognizable HHs may be present in patients with GSs, a careful MRI study of the hypothalamic, infundibular and mammillary bodys areas is mandatory in these cases [published with videosequences].

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalEpileptic Disorders
Issue number2
Publication statusPublished - 2002


  • Drug-resistant epilepsy
  • Gelastic seizures
  • Hypothalamic hamartoma
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Clinical Neurology


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