Small metacarpal bones of low quality in obese children

Silvia Longhi, Bruno Pasquino, Annalisa Calcagno, Enrica Bertelli, Irene Olivieri, Natascia Di Iorgi, Giorgio Radetti

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective It is still not known whether fat mass excess could exert a positive effect on bone. The aim of our study was to evaluate bone strength and quality in a group of overweight and obese children and adolescents by assessing bone geometry at metacarpal bones and ultrasound at phalangeal level. Design and patients This is a cross sectional observational study performed in 123 subjects, aged 11·2 ± 2·9 years. Measurements Digitalized X-rays were evaluated at the level of the 2nd metacarpal bone for the determination of the outer (D) and inner (d) diameter, cortical area (CA), medullary endocortical area (EA), metacarpal index (MI) and bone strength (Bending Breaking Resistance Index; BBRI). A total of 98 subjects underwent amplitude dependent speed of sound (Ad-SOS) and bone transmission time (BTT) assessment by phalangeal ultrasonography. Results SDs for each measured parameter were as follows: Males: D = -0·71 ± 0·95, d = -0·29 ± 0·86, CA = -0·69 ± 0·69, EA = -0·32 ± 0·79, Ad-SOS = -1·14 ± 0·91, BTT = -1·17 ± 1·11 and BBRI (417 ± 151 vs 495 ± 174 mm3) were all significantly lower than in controls (P <0·05). Females: D = -1·03 ± 1·06, d = -0·38 ± 0·92, CA = -0·91 ± 0·72, EA = -0·46 ± 0·79, Ad-SOS = -1·08 ± 1·11, BTT = -0·97 ± 1·07 and BBRI (342 ± 117 vs 649 ± 318 mm3) were all significantly lower than in controls (P <0·05). Conclusions Obese children show an unfavourable bone geometry and a bone of low quality and reduced strength compared to controls at a nonweight bearing skeletal site. This finding seems to support a detrimental effect of fat mass on bone and explain the frequent occurrence of wrist fractures in this group of children.

Original languageEnglish
Pages (from-to)79-85
Number of pages7
JournalClinical Endocrinology
Volume78
Issue number1
DOIs
Publication statusPublished - Jan 2013

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Metacarpal Bones
Bone and Bones
Fats
Wrist
Observational Studies
Ultrasonography
Cross-Sectional Studies
X-Rays

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Longhi, S., Pasquino, B., Calcagno, A., Bertelli, E., Olivieri, I., Di Iorgi, N., & Radetti, G. (2013). Small metacarpal bones of low quality in obese children. Clinical Endocrinology, 78(1), 79-85. https://doi.org/10.1111/j.1365-2265.2012.04476.x

Small metacarpal bones of low quality in obese children. / Longhi, Silvia; Pasquino, Bruno; Calcagno, Annalisa; Bertelli, Enrica; Olivieri, Irene; Di Iorgi, Natascia; Radetti, Giorgio.

In: Clinical Endocrinology, Vol. 78, No. 1, 01.2013, p. 79-85.

Research output: Contribution to journalArticle

Longhi, S, Pasquino, B, Calcagno, A, Bertelli, E, Olivieri, I, Di Iorgi, N & Radetti, G 2013, 'Small metacarpal bones of low quality in obese children', Clinical Endocrinology, vol. 78, no. 1, pp. 79-85. https://doi.org/10.1111/j.1365-2265.2012.04476.x
Longhi, Silvia ; Pasquino, Bruno ; Calcagno, Annalisa ; Bertelli, Enrica ; Olivieri, Irene ; Di Iorgi, Natascia ; Radetti, Giorgio. / Small metacarpal bones of low quality in obese children. In: Clinical Endocrinology. 2013 ; Vol. 78, No. 1. pp. 79-85.
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abstract = "Objective It is still not known whether fat mass excess could exert a positive effect on bone. The aim of our study was to evaluate bone strength and quality in a group of overweight and obese children and adolescents by assessing bone geometry at metacarpal bones and ultrasound at phalangeal level. Design and patients This is a cross sectional observational study performed in 123 subjects, aged 11·2 ± 2·9 years. Measurements Digitalized X-rays were evaluated at the level of the 2nd metacarpal bone for the determination of the outer (D) and inner (d) diameter, cortical area (CA), medullary endocortical area (EA), metacarpal index (MI) and bone strength (Bending Breaking Resistance Index; BBRI). A total of 98 subjects underwent amplitude dependent speed of sound (Ad-SOS) and bone transmission time (BTT) assessment by phalangeal ultrasonography. Results SDs for each measured parameter were as follows: Males: D = -0·71 ± 0·95, d = -0·29 ± 0·86, CA = -0·69 ± 0·69, EA = -0·32 ± 0·79, Ad-SOS = -1·14 ± 0·91, BTT = -1·17 ± 1·11 and BBRI (417 ± 151 vs 495 ± 174 mm3) were all significantly lower than in controls (P <0·05). Females: D = -1·03 ± 1·06, d = -0·38 ± 0·92, CA = -0·91 ± 0·72, EA = -0·46 ± 0·79, Ad-SOS = -1·08 ± 1·11, BTT = -0·97 ± 1·07 and BBRI (342 ± 117 vs 649 ± 318 mm3) were all significantly lower than in controls (P <0·05). Conclusions Obese children show an unfavourable bone geometry and a bone of low quality and reduced strength compared to controls at a nonweight bearing skeletal site. This finding seems to support a detrimental effect of fat mass on bone and explain the frequent occurrence of wrist fractures in this group of children.",
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AU - Di Iorgi, Natascia

AU - Radetti, Giorgio

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N2 - Objective It is still not known whether fat mass excess could exert a positive effect on bone. The aim of our study was to evaluate bone strength and quality in a group of overweight and obese children and adolescents by assessing bone geometry at metacarpal bones and ultrasound at phalangeal level. Design and patients This is a cross sectional observational study performed in 123 subjects, aged 11·2 ± 2·9 years. Measurements Digitalized X-rays were evaluated at the level of the 2nd metacarpal bone for the determination of the outer (D) and inner (d) diameter, cortical area (CA), medullary endocortical area (EA), metacarpal index (MI) and bone strength (Bending Breaking Resistance Index; BBRI). A total of 98 subjects underwent amplitude dependent speed of sound (Ad-SOS) and bone transmission time (BTT) assessment by phalangeal ultrasonography. Results SDs for each measured parameter were as follows: Males: D = -0·71 ± 0·95, d = -0·29 ± 0·86, CA = -0·69 ± 0·69, EA = -0·32 ± 0·79, Ad-SOS = -1·14 ± 0·91, BTT = -1·17 ± 1·11 and BBRI (417 ± 151 vs 495 ± 174 mm3) were all significantly lower than in controls (P <0·05). Females: D = -1·03 ± 1·06, d = -0·38 ± 0·92, CA = -0·91 ± 0·72, EA = -0·46 ± 0·79, Ad-SOS = -1·08 ± 1·11, BTT = -0·97 ± 1·07 and BBRI (342 ± 117 vs 649 ± 318 mm3) were all significantly lower than in controls (P <0·05). Conclusions Obese children show an unfavourable bone geometry and a bone of low quality and reduced strength compared to controls at a nonweight bearing skeletal site. This finding seems to support a detrimental effect of fat mass on bone and explain the frequent occurrence of wrist fractures in this group of children.

AB - Objective It is still not known whether fat mass excess could exert a positive effect on bone. The aim of our study was to evaluate bone strength and quality in a group of overweight and obese children and adolescents by assessing bone geometry at metacarpal bones and ultrasound at phalangeal level. Design and patients This is a cross sectional observational study performed in 123 subjects, aged 11·2 ± 2·9 years. Measurements Digitalized X-rays were evaluated at the level of the 2nd metacarpal bone for the determination of the outer (D) and inner (d) diameter, cortical area (CA), medullary endocortical area (EA), metacarpal index (MI) and bone strength (Bending Breaking Resistance Index; BBRI). A total of 98 subjects underwent amplitude dependent speed of sound (Ad-SOS) and bone transmission time (BTT) assessment by phalangeal ultrasonography. Results SDs for each measured parameter were as follows: Males: D = -0·71 ± 0·95, d = -0·29 ± 0·86, CA = -0·69 ± 0·69, EA = -0·32 ± 0·79, Ad-SOS = -1·14 ± 0·91, BTT = -1·17 ± 1·11 and BBRI (417 ± 151 vs 495 ± 174 mm3) were all significantly lower than in controls (P <0·05). Females: D = -1·03 ± 1·06, d = -0·38 ± 0·92, CA = -0·91 ± 0·72, EA = -0·46 ± 0·79, Ad-SOS = -1·08 ± 1·11, BTT = -0·97 ± 1·07 and BBRI (342 ± 117 vs 649 ± 318 mm3) were all significantly lower than in controls (P <0·05). Conclusions Obese children show an unfavourable bone geometry and a bone of low quality and reduced strength compared to controls at a nonweight bearing skeletal site. This finding seems to support a detrimental effect of fat mass on bone and explain the frequent occurrence of wrist fractures in this group of children.

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