Small-molecule activators of AMP-activated protein kinase as modulators of energy metabolism

D. S. Novikova; A. V. Garabadzhiu; G. Melino; N. A. Barlev; V. G. Tribulovich

Small-molecule activators of AMP-activated protein kinase as modulators of energy metabolism

D. S. Novikova, A. V. Garabadzhiu, G. Melino, N. A. Barlev, V. G. Tribulovich

Istituto Dermopatico dell'Immacolata , IDI

Research output: Contribution to journal › Article › peer-review

Abstract

Activated protein kinase (AMPK) is a key regulator of energy balance at both the cellular and wholebody levels. The activation of AMPK has a considerable potential in the therapy of a number of metabolic disorders as well as cancer. The achievements in the develop ment of smallmolecule activators of AMPK are reviewed.

Original language	English
Pages (from-to)	1497-1517
Number of pages	21
Journal	Russian Chemical Bulletin
Volume	64
Issue number	7
Publication status	Published - Jul 1 2015

Keywords

AMPK activators
AMP—activated protein kinase
Drug design
Energy metabolism

ASJC Scopus subject areas

Chemistry(all)

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abstract = "Activated protein kinase (AMPK) is a key regulator of energy balance at both the cellular and wholebody levels. The activation of AMPK has a considerable potential in the therapy of a number of metabolic disorders as well as cancer. The achievements in the develop ment of smallmolecule activators of AMPK are reviewed.",

keywords = "AMPK activators, AMP—activated protein kinase, Drug design, Energy metabolism",

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AU - Garabadzhiu, A. V.

AU - Melino, G.

AU - Barlev, N. A.

AU - Tribulovich, V. G.

PY - 2015/7/1

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AB - Activated protein kinase (AMPK) is a key regulator of energy balance at both the cellular and wholebody levels. The activation of AMPK has a considerable potential in the therapy of a number of metabolic disorders as well as cancer. The achievements in the develop ment of smallmolecule activators of AMPK are reviewed.

KW - AMPK activators

KW - AMP—activated protein kinase

KW - Drug design

KW - Energy metabolism

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Small-molecule activators of AMP-activated protein kinase as modulators of energy metabolism

Abstract

Keywords

ASJC Scopus subject areas

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