Small-molecule activators of AMP-activated protein kinase as modulators of energy metabolism

D. S. Novikova, A. V. Garabadzhiu, G. Melino, N. A. Barlev, V. G. Tribulovich

Research output: Contribution to journalArticle

Abstract

Activated protein kinase (AMPK) is a key regulator of energy balance at both the cellular and wholebody levels. The activation of AMPK has a considerable potential in the therapy of a number of metabolic disorders as well as cancer. The achievements in the develop ment of smallmolecule activators of AMPK are reviewed.

Original languageEnglish
Pages (from-to)1497-1517
Number of pages21
JournalRussian Chemical Bulletin
Volume64
Issue number7
Publication statusPublished - Jul 1 2015

Keywords

  • AMPK activators
  • AMP—activated protein kinase
  • Drug design
  • Energy metabolism

ASJC Scopus subject areas

  • Chemistry(all)

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  • Cite this

    Novikova, D. S., Garabadzhiu, A. V., Melino, G., Barlev, N. A., & Tribulovich, V. G. (2015). Small-molecule activators of AMP-activated protein kinase as modulators of energy metabolism. Russian Chemical Bulletin, 64(7), 1497-1517.