Small molecules targeting p53 to improve antitumor therapy

Giovanni L. Beretta, L. Gatti, V. Benedetti, P. Perego, F. Zunino

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Small molecules targeting p53 represent an emerging group of potentially useful agents for the improvement of antitumor therapy. These modulators include agents that activate wild-type p53 or reactivate mutant p53 and inhibitors of p53 functions. Preclinical evidences support the interest of combination strategies with conventional antitumor agents.

Original languageEnglish
Pages (from-to)856-868
Number of pages13
JournalMini-Reviews in Medicinal Chemistry
Volume8
Issue number9
DOIs
Publication statusPublished - 2008

Fingerprint

Antineoplastic Agents
Molecules
Modulators
Therapeutics

Keywords

  • Apoptosis
  • Cancer cells
  • Drug combination
  • Histone deacetylase inhibitors
  • Nutlins
  • p53
  • Pifithrins
  • Ubiquitin ligase inhibitors

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Chemistry(all)
  • Pharmacology

Cite this

Small molecules targeting p53 to improve antitumor therapy. / Beretta, Giovanni L.; Gatti, L.; Benedetti, V.; Perego, P.; Zunino, F.

In: Mini-Reviews in Medicinal Chemistry, Vol. 8, No. 9, 2008, p. 856-868.

Research output: Contribution to journalArticle

Beretta, Giovanni L. ; Gatti, L. ; Benedetti, V. ; Perego, P. ; Zunino, F. / Small molecules targeting p53 to improve antitumor therapy. In: Mini-Reviews in Medicinal Chemistry. 2008 ; Vol. 8, No. 9. pp. 856-868.
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