Small molecules targeting p53 to improve antitumor therapy

Giovanni L. Beretta, L. Gatti, V. Benedetti, P. Perego, F. Zunino

Research output: Contribution to journalArticle

Abstract

Small molecules targeting p53 represent an emerging group of potentially useful agents for the improvement of antitumor therapy. These modulators include agents that activate wild-type p53 or reactivate mutant p53 and inhibitors of p53 functions. Preclinical evidences support the interest of combination strategies with conventional antitumor agents.

Original languageEnglish
Pages (from-to)856-868
Number of pages13
JournalMini-Reviews in Medicinal Chemistry
Volume8
Issue number9
DOIs
Publication statusPublished - 2008

Keywords

  • Apoptosis
  • Cancer cells
  • Drug combination
  • Histone deacetylase inhibitors
  • Nutlins
  • p53
  • Pifithrins
  • Ubiquitin ligase inhibitors

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Chemistry(all)
  • Pharmacology

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