Small molecules targeting p53 to improve antitumor therapy

Giovanni L. Beretta; L. Gatti; V. Benedetti; P. Perego; F. Zunino

doi:10.2174/138955708785132774

Small molecules targeting p53 to improve antitumor therapy

Giovanni L. Beretta, L. Gatti, V. Benedetti, P. Perego, F. Zunino

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Small molecules targeting p53 represent an emerging group of potentially useful agents for the improvement of antitumor therapy. These modulators include agents that activate wild-type p53 or reactivate mutant p53 and inhibitors of p53 functions. Preclinical evidences support the interest of combination strategies with conventional antitumor agents.

Original language	English
Pages (from-to)	856-868
Number of pages	13
Journal	Mini-Reviews in Medicinal Chemistry
Volume	8
Issue number	9
DOIs	https://doi.org/10.2174/138955708785132774
Publication status	Published - 2008

Keywords

Apoptosis
Cancer cells
Drug combination
Histone deacetylase inhibitors
Nutlins
p53
Pifithrins
Ubiquitin ligase inhibitors

ASJC Scopus subject areas

Medicine (miscellaneous)
Chemistry(all)
Pharmacology

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title = "Small molecules targeting p53 to improve antitumor therapy",

abstract = "Small molecules targeting p53 represent an emerging group of potentially useful agents for the improvement of antitumor therapy. These modulators include agents that activate wild-type p53 or reactivate mutant p53 and inhibitors of p53 functions. Preclinical evidences support the interest of combination strategies with conventional antitumor agents.",

keywords = "Apoptosis, Cancer cells, Drug combination, Histone deacetylase inhibitors, Nutlins, p53, Pifithrins, Ubiquitin ligase inhibitors",

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AU - Beretta, Giovanni L.

AU - Gatti, L.

AU - Benedetti, V.

AU - Perego, P.

AU - Zunino, F.

PY - 2008

Y1 - 2008

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AB - Small molecules targeting p53 represent an emerging group of potentially useful agents for the improvement of antitumor therapy. These modulators include agents that activate wild-type p53 or reactivate mutant p53 and inhibitors of p53 functions. Preclinical evidences support the interest of combination strategies with conventional antitumor agents.

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KW - Cancer cells

KW - Drug combination

KW - Histone deacetylase inhibitors

KW - Nutlins

KW - p53

KW - Pifithrins

KW - Ubiquitin ligase inhibitors

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Small molecules targeting p53 to improve antitumor therapy

Abstract

Keywords

ASJC Scopus subject areas

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